Article Figures & Data
Additional Files
Data Supplement
- Supplemental Data -
Supplementary Figure 1 - Caffeine Plasma Concentrations in Individuals Who Appear to have Taken Dietary Caffeine in Period 1/2.
Supplementary Table 1 - Selected details related to the conduct and interpretation of in vitro studies to assess the effects of abemaciclib, M2, and M20 on CYP mRNA and activity in cultured human hepatocytes, with selected Emax and EC50 values.
Supplementary Table 2 - TaqMan Gene Expression Assays used for RT-qPCR of mRNA isolated from human hepatocytes.
Supplementary Table 3 - Mass spectrometry conditions used for in vitro selective activity assays for CYP1A2, CYP2B6, and CYP3A from the in vitro study conducted in primary cultures of human hepatocytes.
Supplementary Table 4 - Parameters used as inputs for Equations 2 and 3.
Supplementary Table 5 - Changes in CYP mRNA and activity measured in cultured hepatocytes following 2 days of treatment with abemaciclib, M2, and M20, presented as percent change from 0.1% DMSO control.
- Supplemental Data -