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A multi compartment human kidney proximal tubule-on-a-chip replicates cell polarization-dependent cisplatin toxicity

Tom T.G. Nieskens, Mikael Persson, Edward J. Kelly and Anna-Karin Sjögren
Drug Metabolism and Disposition October 5, 2020, DMD-AR-2020-000098; DOI: https://doi.org/10.1124/dmd.120.000098
Tom T.G. Nieskens
1Clinical Pharmacology and Safety Sciences, AstraZeneca R&D, Sweden
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Mikael Persson
1Clinical Pharmacology and Safety Sciences, AstraZeneca R&D, Sweden
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Edward J. Kelly
2Pharmaceutics, University of Washington, United States of America
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Anna-Karin Sjögren
1Clinical Pharmacology and Safety Sciences, AstraZeneca R&D, Sweden
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  • For correspondence: anna-karin.sjogren@astrazeneca.com
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Article Information

DMD-AR-2020-000098
DOI 
https://doi.org/10.1124/dmd.120.000098
PubMed 
33020068

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Published online October 5, 2020.

Article Versions

  • You are currently viewing an Earlier version of this article (October 5, 2020 - 13:47).
  • View the most recent version of this article
Copyright & Usage 
Copyright © 2020 American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Tom T.G. Nieskens1,
  2. Mikael Persson1,
  3. Edward J. Kelly2, and
  4. Anna-Karin Sjögren1,*
  1. 1Clinical Pharmacology and Safety Sciences, AstraZeneca R&D, Sweden
  2. 2Pharmaceutics, University of Washington, United States of America
  1. ↵* Corresponding Author:
    Anna-Karin Sjögren, Clinical Pharmacology and Safety Sciences, AstraZeneca R&D, Pepparedsleden 1, Mölndal, N/A, 43183, Sweden. E-mail: anna-karin.sjogren{at}astrazeneca.com

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Drug Metabolism and Disposition: 50 (6)
Drug Metabolism and Disposition
Vol. 50, Issue 6
1 Jun 2022
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Polarization determines kidney-on-a-chip cisplatin toxicity

Tom T.G. Nieskens, Mikael Persson, Edward J. Kelly and Anna-Karin Sjögren
Drug Metabolism and Disposition October 5, 2020, DMD-AR-2020-000098; DOI: https://doi.org/10.1124/dmd.120.000098

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OtherArticle

Polarization determines kidney-on-a-chip cisplatin toxicity

Tom T.G. Nieskens, Mikael Persson, Edward J. Kelly and Anna-Karin Sjögren
Drug Metabolism and Disposition October 5, 2020, DMD-AR-2020-000098; DOI: https://doi.org/10.1124/dmd.120.000098
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