A multi compartment human kidney proximal tubule-on-a-chip replicates cell polarization-dependent cisplatin toxicity

Tom T.G. Nieskens; Mikael Persson; Edward J. Kelly; Anna-Karin Sjögren

doi:10.1124/dmd.120.000098

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A multi compartment human kidney proximal tubule-on-a-chip replicates cell polarization-dependent cisplatin toxicity

Tom T.G. Nieskens, Mikael Persson, Edward J. Kelly and Anna-Karin Sjögren

Drug Metabolism and Disposition October 5, 2020, DMD-AR-2020-000098; DOI: https://doi.org/10.1124/dmd.120.000098

Tom T.G. Nieskens

1Clinical Pharmacology and Safety Sciences, AstraZeneca R&D, Sweden

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Mikael Persson

1Clinical Pharmacology and Safety Sciences, AstraZeneca R&D, Sweden

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Edward J. Kelly

2Pharmaceutics, University of Washington, United States of America

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Anna-Karin Sjögren

1Clinical Pharmacology and Safety Sciences, AstraZeneca R&D, Sweden

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For correspondence: anna-karin.sjogren@astrazeneca.com

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Drug Metabolism and Disposition

Vol. 50, Issue 6

1 Jun 2022

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Polarization determines kidney-on-a-chip cisplatin toxicity

Tom T.G. Nieskens, Mikael Persson, Edward J. Kelly and Anna-Karin Sjögren

Drug Metabolism and Disposition October 5, 2020, DMD-AR-2020-000098; DOI: https://doi.org/10.1124/dmd.120.000098

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Polarization determines kidney-on-a-chip cisplatin toxicity

Tom T.G. Nieskens, Mikael Persson, Edward J. Kelly and Anna-Karin Sjögren

Drug Metabolism and Disposition October 5, 2020, DMD-AR-2020-000098; DOI: https://doi.org/10.1124/dmd.120.000098

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A multi compartment human kidney proximal tubule-on-a-chip replicates cell polarization-dependent cisplatin toxicity

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