Article Figures & Data
Additional Files
Data Supplement
- Supplemental Figures -
Supplemental Figure 1 - Mass spectroscopic methods facilitated direct detection of meclofenamate and suspected monohydroxylated metabolites of meclofenamate.
Supplemental Figure 2 - Optimal reaction times were established for meclofenamate kinetic assessment.
Supplemental Figure 3 - Optimal enzyme concentrations were established for meclofenamate kinetic assessment.
Supplemental Figure 4 - Steady-state kinetics for meclofenamate metabolism up to 500 μM.
Supplemental Figure 5 - Metabolic map for meclofenamate bioactivation.
Supplemental Figure 6 - Numerical computational model outputs which provide whole-molecule and atomby-atom scores for meclofenamate bioactivation into quinone-species metabolites.
Supplemental Figure 7 - Graphical computational model outputs which show potential bioactivation pathways of meclofenamate into nineteen quinone-species metabolites with subsequent scoring for reactivity with glutathione.
Supplemental Figure 8 - Graphical computational model outputs which show potential bioactivation pathways of meclofenamate into nineteen quinone-species metabolites with subsequent scoring for reactivity with endogenous proteins.
- Supplemental Figures -