Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn
OtherArticle

Function and Expression of Bile Salt Export Pump in Suspension Human Hepatocytes

Paresh P. Chothe, Rachel Pemberton and Niresh Hariparsad
Drug Metabolism and Disposition January 20, 2021, DMD-AR-2020-000057; DOI: https://doi.org/10.1124/dmd.120.000057
Paresh P. Chothe
1Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: pareshchothe@yahoo.com
Rachel Pemberton
2Drug Metabolism and Pharmacokinetics, Vertex Pharmaceuticals Incorporated, United States
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Niresh Hariparsad
3Drug Metabolism and Disposition, Vertex Pharmaceuticals, United States of America
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF + SI
  • PDF
Loading

Article Figures & Data

Additional Files

  • Data Supplement

    • Supplemental Data -

      Supplemental Figure 1 - Efflux of Glycine- and Taurine-conjugated CA and CDCA in Human Hepatocyte Suspension (WWQ).

      Supplemental Figure 2 - Uptake Analysis of Estradiol-17β glucuronide, DHEAS and TCA in human MRP3, MRP4 and BSEP Overexpressed Membrane Vesicles, respectively.

      Supplemental Figure 3 - Uptake Analysis of Taurocholate and Atorvastatin in Pooled Suspension Human Hepatocytes (YJG).

      Supplemental Table 1 - Demographic Information of Human Hepatocyte Donors.

      Supplemental Table 2 - The multiple Reaction Monitoring (MRM) Transitions of Compounds.

      Supplemental Table 3 - Human transporter proteotypic heavy labeled tryptic peptide standards.

      Supplemental Table 4 - Uptake data of Cholic Acid (CA) and Chenodeoxycholic Acid (CDCA) in Pooled Human Suspension Hepatocytes

      Supplemental Table 5 - Permeability of Cholic Acid (CA) and Chenodeoxycholic Acid (CDCA) and Their Glycine- and Taurine-conjugated Salts.

      Supplemental Table 6 - Summary of Uptake Data of Bile Salts in MRP3 Membrane Vesicles.

      Supplemental Table 7 - Summary of Uptake Data of Bile Salts in MRP4 Membrane Vesicles.

      Supplemental Table 8 - Summary of Uptake Data of Bile Salts in BSEP Membrane Vesicles.

PreviousNext
Back to top

In this issue

Drug Metabolism and Disposition: 49 (3)
Drug Metabolism and Disposition
Vol. 49, Issue 3
1 Mar 2021
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Drug Metabolism & Disposition article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Function and Expression of Bile Salt Export Pump in Suspension Human Hepatocytes
(Your Name) has forwarded a page to you from Drug Metabolism & Disposition
(Your Name) thought you would be interested in this article in Drug Metabolism & Disposition.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
OtherArticle

BSEP Function in Suspension Hepatocytes

Paresh P. Chothe, Rachel Pemberton and Niresh Hariparsad
Drug Metabolism and Disposition January 20, 2021, DMD-AR-2020-000057; DOI: https://doi.org/10.1124/dmd.120.000057

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
OtherArticle

BSEP Function in Suspension Hepatocytes

Paresh P. Chothe, Rachel Pemberton and Niresh Hariparsad
Drug Metabolism and Disposition January 20, 2021, DMD-AR-2020-000057; DOI: https://doi.org/10.1124/dmd.120.000057
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF + SI
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Clearance pathways: fevipiprant with probenecid perpetrator
  • Predicting Volume of Distribution from In Vitro Parameters
  • In Vivo Functional Effects of CYP2C9 M1L
Show more Article

Similar Articles

  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2021 by the American Society for Pharmacology and Experimental Therapeutics