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Evaluation of Tissue Binding in 3 Tissues Across 5 Species, and Prediction of Volume of Distribution from Plasma Protein and Tissue Binding

Frederick Hsu, Ivy Chen and Fabio Broccatelli
Drug Metabolism and Disposition February 2, 2021, DMD-AR-2020-000337; DOI: https://doi.org/10.1124/dmd.120.000337

Article Information

DMD-AR-2020-000337
DOI 
https://doi.org/10.1124/dmd.120.000337
PubMed 
33531412
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Published online February 2, 2021.

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Copyright © 2020 American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Frederick Hsu1,
  2. Ivy Chen2, and
  3. Fabio Broccatelli3,*
  1. 1Drug Metabolism and Pharmacokinetics, Genentech, United States of America
  2. 2Genentech, United States of America
  3. 3DMPK, Genentech, United States of America
  1. ↵* Corresponding Author:
    Fabio Broccatelli, DMPK, Genentech, California, United States of America. E-mail: fabio.broccatelli{at}gmail.com

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Predicting Volume of Distribution from In Vitro Parameters

Frederick Hsu, Ivy Chen and Fabio Broccatelli
Drug Metabolism and Disposition February 2, 2021, DMD-AR-2020-000337; DOI: https://doi.org/10.1124/dmd.120.000337
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