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Pharmacokinetic and biochemical profiling of Sodium Dichloroacetate in pregnant ewes and fetuses

Serene Joseph, Abhisheak Sharma, Lloyd P. Horne, Charles E. Wood, Taimour Langaee, Margaret O. James, Peter W. Stacpoole and Maureen Keller-Wood
Drug Metabolism and Disposition April 2, 2021, DMD-AR-2020-000330; DOI: https://doi.org/10.1124/dmd.120.000330
Serene Joseph
1Department of Pharmacodynamics, College of Pharmacy, University of Florida, United States of America
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  • For correspondence: serenejoseph@ufl.edu
Abhisheak Sharma
2Pharmaceutics, University of Florida, United States of America
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  • ORCID record for Abhisheak Sharma
Lloyd P. Horne
3Medicine, University of Florida, United States
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Charles E. Wood
4Department of Physiology and Functional Genomics, University of Florida, United States of America
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Taimour Langaee
5Pharmacy Practice, University of Florida, United States of America
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Margaret O. James
6Department of Medicinal Chemistry, University of Florida, United States of America
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Peter W. Stacpoole
7Department of Medicine, University of Florida, United States of America
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Maureen Keller-Wood
8Department of Pharmacodynamics, University of Florida, United States of America
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    • Supplemental Data -

      Supplemental Figure 1 - Visual predictive checks (VPC) of the final model for DCA in mother and fetus.

      Supplemental Figure 2 - Observed concentrations and individual predictions versus time (CObs, mother and CObs2, fetus) using data in Study I.

      Supplemental Figure 3 - Representative figure showing GSTZ1 bands from maternal and fetal mitochondrial samples.

      Supplemental Table 1 - Primer sequences used in PCR and sequencing of the ovine GSTZ1 gene.

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Drug Metabolism and Disposition: 49 (5)
Drug Metabolism and Disposition
Vol. 49, Issue 5
1 May 2021
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OtherArticle

Pharmacokinetic and biochemical profiling of DCA

Serene Joseph, Abhisheak Sharma, Lloyd P. Horne, Charles E. Wood, Taimour Langaee, Margaret O. James, Peter W. Stacpoole and Maureen Keller-Wood
Drug Metabolism and Disposition April 2, 2021, DMD-AR-2020-000330; DOI: https://doi.org/10.1124/dmd.120.000330

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OtherArticle

Pharmacokinetic and biochemical profiling of DCA

Serene Joseph, Abhisheak Sharma, Lloyd P. Horne, Charles E. Wood, Taimour Langaee, Margaret O. James, Peter W. Stacpoole and Maureen Keller-Wood
Drug Metabolism and Disposition April 2, 2021, DMD-AR-2020-000330; DOI: https://doi.org/10.1124/dmd.120.000330
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