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Improving the Translation of Organic Anion Transporting Polypeptide Substrates using HEK293 Cell Data in the Presence and Absence of Human Plasma via PBPK Modeling
Christine M. Bowman, Buyun Chen, Jonathan Cheong, Liling Liu, Yuan Chen and Jialin Mao
Drug Metabolism and Disposition May 6, 2021, DMD-AR-2020-000315; DOI: https://doi.org/10.1124/dmd.120.000315
Christine M. Bowman
1Genentech, Roche, United States
Buyun Chen
2Genentech, United States
Jonathan Cheong
2Genentech, United States
Liling Liu
2Genentech, United States
Yuan Chen
3Drug metabolism and pharmacokinetics, Genentech, United States
Jialin Mao
4Genentech, A Member of the Roche Group, United States
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PBPK Modeling of OATP Substrates with HEK293 Data +/- Plasma
Christine M. Bowman, Buyun Chen, Jonathan Cheong, Liling Liu, Yuan Chen and Jialin Mao
Drug Metabolism and Disposition May 6, 2021, DMD-AR-2020-000315; DOI: https://doi.org/10.1124/dmd.120.000315
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