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Hepatic Scaling Factors for In Vitro-In Vivo Extrapolation (IVIVE) of Metabolic Drug Clearance in Patients with Colorectal Cancer with Liver Metastasis

Areti-Maria Vasilogianni, Brahim Achour, Daniel Scotcher, Sheila Annie Peters, Zubida M. Al-Majdoub, Jill Barber and Amin Rostami-Hodjegan
Drug Metabolism and Disposition May 12, 2021, DMD-AR-2021-000359; DOI: https://doi.org/10.1124/dmd.121.000359
Areti-Maria Vasilogianni
1University of Manchester, United Kingdom
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  • ORCID record for Areti-Maria Vasilogianni
Brahim Achour
2Manchester Pharmacy School, University of Manchester, United Kingdom
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Daniel Scotcher
3Centre for Applied Pharmacokinetic Research, Univversity of Manchester, United Kingdom
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Sheila Annie Peters
4Translational Quantitative Pharmacology, BioPharma, R&D Global Early Development, Merck KGaA, Germany
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Zubida M. Al-Majdoub
5Division of Pharmacy and Optometry, University of Manchester, United Kingdom
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  • ORCID record for Zubida M. Al-Majdoub
Jill Barber
6Pharmacy and Pharmaceutical Sciences, University of Manchester, United Kingdom
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Amin Rostami-Hodjegan
7Systems Pharmacology, Manchester Pharmacy School, University of Manchester, United Kingdom
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  • ORCID record for Amin Rostami-Hodjegan
  • For correspondence: amin.rostami@manchester.ac.uk
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Article Information

DMD-AR-2021-000359
DOI 
https://doi.org/10.1124/dmd.121.000359
PubMed 
33980603

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Published online May 12, 2021.

Article Versions

  • You are currently viewing an Earlier version of this article (May 12, 2021 - 14:03).
  • View the most recent version of this article
Copyright & Usage 
Copyright © 2020 American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Areti-Maria Vasilogianni1,
  2. Brahim Achour2,
  3. Daniel Scotcher3,
  4. Sheila Annie Peters4,
  5. Zubida M. Al-Majdoub5,
  6. Jill Barber6, and
  7. Amin Rostami-Hodjegan7,*
  1. 1University of Manchester, United Kingdom
  2. 2Manchester Pharmacy School, University of Manchester, United Kingdom
  3. 3Centre for Applied Pharmacokinetic Research, Univversity of Manchester, United Kingdom
  4. 4Translational Quantitative Pharmacology, BioPharma, R&D Global Early Development, Merck KGaA, Germany
  5. 5Division of Pharmacy and Optometry, University of Manchester, United Kingdom
  6. 6Pharmacy and Pharmaceutical Sciences, University of Manchester, United Kingdom
  7. 7Systems Pharmacology, Manchester Pharmacy School, University of Manchester, United Kingdom
  1. ↵* Corresponding Author:
    Amin Rostami-Hodjegan, Systems Pharmacology, Manchester Pharmacy School, University of Manchester, Stopford Building, Manchester Pharmacy School, Oxford Road, Manchester, M13 9PT, United Kingdom. E-mail: amin.rostami{at}manchester.ac.uk

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Drug Metabolism and Disposition: 50 (8)
Drug Metabolism and Disposition
Vol. 50, Issue 8
1 Aug 2022
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Hepatic scaling factors for CL in colorectal cancer

Areti-Maria Vasilogianni, Brahim Achour, Daniel Scotcher, Sheila Annie Peters, Zubida M. Al-Majdoub, Jill Barber and Amin Rostami-Hodjegan
Drug Metabolism and Disposition May 12, 2021, DMD-AR-2021-000359; DOI: https://doi.org/10.1124/dmd.121.000359

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OtherArticle

Hepatic scaling factors for CL in colorectal cancer

Areti-Maria Vasilogianni, Brahim Achour, Daniel Scotcher, Sheila Annie Peters, Zubida M. Al-Majdoub, Jill Barber and Amin Rostami-Hodjegan
Drug Metabolism and Disposition May 12, 2021, DMD-AR-2021-000359; DOI: https://doi.org/10.1124/dmd.121.000359
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