Article Figures & Data
Additional Files
Data Supplement
- Supplemental Data -
Supplemental Figure 1 - Acid-lactone conversion in human intestine microsomal incubations.
Supplemental Figure 2 -The kinetics of mevalonate formation by HMG-CoA reductase was best described by a substrate inhibition model.
Supplemental Table 1 - The characteristic multiple reaction monitoring (MRM) transitions of the analytes and internal standards.
Supplemental Table 2 - Incubation concentrations (C0) of the statin compounds tested and literature Km values from HLM and recombinant CYP and UGT incubations.
Supplemental Table 3 - Comparison of CLint values obtained in the depletion experiment in NADPH-supplemented HLMs with those found in the literature.
Supplemental Table 4 - Comparison of CLint values obtained in HIM incubations with those found in the literature.
Supplemental Table 5 - Comparison of the IC50 values (nM) obtained in the present pharmacodynamic experiment with those of some previous studies.
References
- Supplemental Data -