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The Nonclinical Disposition and PK/PD Properties of GalNAc-conjugated siRNA Are Highly Predictable and Build Confidence in Translation to Man

Saeho Chong, Sagar Agarwal, Saket Agarwal, Krishna C. Aluri, Michael Arciprete, Christopher Brown, Klaus Charisse, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeff Kurz, Jing Li, Steven Liou, Ju Liu, Xiumin Liu, Christopher Maclauchlin, Martin Maier, Muthiah Manoharan, Robin McDougall, Jay Nair, Diane Ramsden, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Jing-Tao Wu, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Elena castellanos-Rizaldos
Drug Metabolism and Disposition June 21, 2021, DMD-MR-2021-000428; DOI: https://doi.org/10.1124/dmd.121.000428

Article Information

DMD-MR-2021-000428
DOI 
https://doi.org/10.1124/dmd.121.000428
PubMed 
34154993
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Published online June 21, 2021.

Article Versions

Copyright & Usage 
© 2020 The Authors. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited and is not used for commercial purposes.

Author Information

  1. Saeho Chong1,
  2. Sagar Agarwal2,
  3. Saket Agarwal3,
  4. Krishna C. Aluri4,
  5. Michael Arciprete5,
  6. Christopher Brown6,
  7. Klaus Charisse7,
  8. Joseph Cichocki8,
  9. Kevin Fitzgerald9,
  10. Varun Goel10,
  11. Yongli Gu11,
  12. Dale Guenther12,
  13. Bahru Habtemariam2,
  14. Vasant Jadhav6,
  15. Maja Janas3,
  16. Muthusamy Jayaraman13,
  17. Jeff Kurz14,
  18. Jing Li5,
  19. Steven Liou14,
  20. Ju Liu5,
  21. Xiumin Liu14,
  22. Christopher Maclauchlin14,
  23. Martin Maier14,
  24. Muthiah Manoharan9,
  25. Robin McDougall1,
  26. Jay Nair7,
  27. Diane Ramsden15,
  28. Gabriel Robbie2,
  29. Karyn Schmidt6,
  30. Peter Smith5,
  31. Christopher Theile7,
  32. Akshay Vaishnaw9,
  33. Scott Waldron9,
  34. Jing-Tao Wu16,*,
  35. Yuanxin Xu5,
  36. Xuemei Zhang5,
  37. Ivan Zlatev7, and
  38. Elena castellanos-Rizaldos6
  1. 1Drug Metabolism and Pharmacokinetics, Alnylam Pharmaceuticals Inc., United States
  2. 2Clinical Pharmacology, Alnylam Pharmaceuticals, United States
  3. 3Investigative Toxicology, Alnylam Pharmaceuticals, United States
  4. 4Early Development, Alnylam pharmaceuticals, United States
  5. 5Alnylam Pharmaceuticals Inc., United States
  6. 6Biology, Alnylam Pharmaceuticals, United States
  7. 7Chemistry, Alnylam Pharmaceuticals, United States
  8. 8Toxicology, Vertex Pharmaceuticals, United States
  9. 9Research, Alnylam Pharmaceuticals, United States
  10. 10Clinical Pharmacology, Avidity Bioscience, United States
  11. 11Bioanalytical Science, Alnylam Pharmaceuticals, United States
  12. 12RNAi Discovery, Alnylam Pharmaceuticals, United States
  13. 13CRISPR Therapeutics, United States
  14. 14DMPK, Alnylam Pharmaceuticals, United States
  15. 15DMPK, Takeda, United States
  16. 16DMPK, Alnylam, United States
  1. ↵* Corresponding Author:
    Jing-Tao Wu, DMPK, Alnylam, 300 Third Street, Cambridge, 2142, United States. E-mail: jtwu{at}alnylam.com

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Article usage: June 2021 to September 2024

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Disposition and PK/PD of GalNAc-siRNA

Saeho Chong, Sagar Agarwal, Saket Agarwal, Krishna C. Aluri, Michael Arciprete, Christopher Brown, Klaus Charisse, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeff Kurz, Jing Li, Steven Liou, Ju Liu, Xiumin Liu, Christopher Maclauchlin, Martin Maier, Muthiah Manoharan, Robin McDougall, Jay Nair, Diane Ramsden, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Jing-Tao Wu, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Elena castellanos-Rizaldos
Drug Metabolism and Disposition June 21, 2021, DMD-MR-2021-000428; DOI: https://doi.org/10.1124/dmd.121.000428
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