Data Supplement

• Supplemental Data -

  Methods

  Supplemental Table 1 - In vitro evaluation of single and duplex stability in the presence of enzymes known to cleave RNA and DNA.
  

  Supplemental Table 2 - Cross species metabolite profiles from plated hepatocytes and nonclinical liver samples.
  

  Supplemental Figure 1 - Electrophoretic mobility shift assay (EMSA) results for siRNA2 and siRNA19 following a 1:1 mixture of sense strands (SS), antisense strands (AS) and duplex strands in PBS (Panel A).
  

  Supplemental Figure 2 - Evaluation of sense strand metabolites in rat (Panel A) and monkey (Panel B) liver samples following SC administration of siRNA6.