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Cytochrome P450 Binding and Bioactivation of Tumor-targeted Duocarmycin Agents
Aaron G. Bart, Goreti Morais, Venu R. Vangala, Paul M. Loadman, Klaus Pors and Emily E. Scott
Drug Metabolism and Disposition October 4, 2021, DMD-AR-2021-000642; DOI: https://doi.org/10.1124/dmd.121.000642
Aaron G. Bart
1University of Michigan, United States
Goreti Morais
2University of Bradford, United Kingdom
Venu R. Vangala
2University of Bradford, United Kingdom
Paul M. Loadman
3Institute of Cancer Therapeutics, University of Bradford, United Kingdom
Klaus Pors
2University of Bradford, United Kingdom
Emily E. Scott
4Dept of Medicinal Chemistry, University of Michigan, United States
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P450 Activation of Duocarmycin Prodrugs
Aaron G. Bart, Goreti Morais, Venu R. Vangala, Paul M. Loadman, Klaus Pors and Emily E. Scott
Drug Metabolism and Disposition October 4, 2021, DMD-AR-2021-000642; DOI: https://doi.org/10.1124/dmd.121.000642
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