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The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study

Erin C Berthold, Shyam H Kamble, Kanumuri S Raju, Michelle A Kuntz, Alexandria S Senetra, Marco Mottinelli, Francisco León, Luis F Restrepo, Avi Patel, Nicholas P Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy
Drug Metabolism and Disposition November 10, 2021, DMD-AR-2021-000640; DOI: https://doi.org/10.1124/dmd.121.000640
Erin C Berthold
1Pharmaceutics, University of Florida, United States
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Shyam H Kamble
2Pharmaceutics, University of Florida College of Pharmacy, United States
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Kanumuri S Raju
2Pharmaceutics, University of Florida College of Pharmacy, United States
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Michelle A Kuntz
2Pharmaceutics, University of Florida College of Pharmacy, United States
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Alexandria S Senetra
1Pharmaceutics, University of Florida, United States
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Marco Mottinelli
3Medicinal Chemistry, College of Pharmacy, University of Florida, United States
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Francisco León
3Medicinal Chemistry, College of Pharmacy, University of Florida, United States
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Luis F Restrepo
4Pharmacodynamics, College of Pharmacy, University of Florida, United States
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Avi Patel
4Pharmacodynamics, College of Pharmacy, University of Florida, United States
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Nicholas P Ho
5Pharmacodynamics, University of Florida College of Pharmacy, United States
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Takato Hiranita
4Pharmacodynamics, College of Pharmacy, University of Florida, United States
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Abhisheak Sharma
1Pharmaceutics, University of Florida, United States
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  • For correspondence: cmccurdy@cop.ufl.edu
Lance R. McMahon
6Pharmacology, University of Florida, United States
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Christopher R. McCurdy
7College of Pharmacy, University of Florida, United States
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  • For correspondence: cmccurdy@cop.ufl.edu
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Article Information

DMD-AR-2021-000640
DOI 
https://doi.org/10.1124/dmd.121.000640
PubMed 
34759012

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Published online November 10, 2021.

Article Versions

  • You are currently viewing an Earlier version of this article (November 10, 2021 - 10:38).
  • View the most recent version of this article
Copyright & Usage 
Copyright © 2020 American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Erin C Berthold1,
  2. Shyam H Kamble2,
  3. Kanumuri S Raju2,
  4. Michelle A Kuntz2,
  5. Alexandria S Senetra1,
  6. Marco Mottinelli3,
  7. Francisco León3,
  8. Luis F Restrepo4,
  9. Avi Patel4,
  10. Nicholas P Ho5,
  11. Takato Hiranita4,
  12. Abhisheak Sharma1,*,
  13. Lance R. McMahon6, and
  14. Christopher R. McCurdy7,*
  1. 1Pharmaceutics, University of Florida, United States
  2. 2Pharmaceutics, University of Florida College of Pharmacy, United States
  3. 3Medicinal Chemistry, College of Pharmacy, University of Florida, United States
  4. 4Pharmacodynamics, College of Pharmacy, University of Florida, United States
  5. 5Pharmacodynamics, University of Florida College of Pharmacy, United States
  6. 6Pharmacology, University of Florida, United States
  7. 7College of Pharmacy, University of Florida, United States
  1. ↵* Corresponding Author:
    Christopher R. McCurdy, College of Pharmacy, University of Florida, Florida, United States. E-mail: cmccurdy{at}cop.ufl.edu
  2. * Corresponding Author; email: asharma1{at}cop.ufl.edu

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Dec 20213113102
Jan 202238927101
Feb 20228115475
Mar 20222993182
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Drug Metabolism and Disposition: 50 (6)
Drug Metabolism and Disposition
Vol. 50, Issue 6
1 Jun 2022
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7-OH mitragynine alone cannot explain mitragynine analgesia

Erin C Berthold, Shyam H Kamble, Kanumuri S Raju, Michelle A Kuntz, Alexandria S Senetra, Marco Mottinelli, Francisco León, Luis F Restrepo, Avi Patel, Nicholas P Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy
Drug Metabolism and Disposition November 10, 2021, DMD-AR-2021-000640; DOI: https://doi.org/10.1124/dmd.121.000640

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OtherArticle

7-OH mitragynine alone cannot explain mitragynine analgesia

Erin C Berthold, Shyam H Kamble, Kanumuri S Raju, Michelle A Kuntz, Alexandria S Senetra, Marco Mottinelli, Francisco León, Luis F Restrepo, Avi Patel, Nicholas P Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy
Drug Metabolism and Disposition November 10, 2021, DMD-AR-2021-000640; DOI: https://doi.org/10.1124/dmd.121.000640
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