The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study

Erin C Berthold; Shyam H Kamble; Kanumuri S Raju; Michelle A Kuntz; Alexandria S Senetra; Marco Mottinelli; Francisco León; Luis F Restrepo; Avi Patel; Nicholas P Ho; Takato Hiranita; Abhisheak Sharma; Lance R. McMahon; Christopher R. McCurdy

doi:10.1124/dmd.121.000640

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The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study

Erin C Berthold, Shyam H Kamble, Kanumuri S Raju, Michelle A Kuntz, Alexandria S Senetra, Marco Mottinelli, Francisco León, Luis F Restrepo, Avi Patel, Nicholas P Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy

Drug Metabolism and Disposition November 10, 2021, DMD-AR-2021-000640; DOI: https://doi.org/10.1124/dmd.121.000640

Erin C Berthold

1Pharmaceutics, University of Florida, United States

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Shyam H Kamble

2Pharmaceutics, University of Florida College of Pharmacy, United States

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Kanumuri S Raju

2Pharmaceutics, University of Florida College of Pharmacy, United States

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Michelle A Kuntz

2Pharmaceutics, University of Florida College of Pharmacy, United States

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Alexandria S Senetra

1Pharmaceutics, University of Florida, United States

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Marco Mottinelli

3Medicinal Chemistry, College of Pharmacy, University of Florida, United States

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Francisco León

3Medicinal Chemistry, College of Pharmacy, University of Florida, United States

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Luis F Restrepo

4Pharmacodynamics, College of Pharmacy, University of Florida, United States

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Avi Patel

4Pharmacodynamics, College of Pharmacy, University of Florida, United States

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Nicholas P Ho

5Pharmacodynamics, University of Florida College of Pharmacy, United States

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Takato Hiranita

4Pharmacodynamics, College of Pharmacy, University of Florida, United States

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Abhisheak Sharma

1Pharmaceutics, University of Florida, United States

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For correspondence: cmccurdy@cop.ufl.edu

Lance R. McMahon

6Pharmacology, University of Florida, United States

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Christopher R. McCurdy

7College of Pharmacy, University of Florida, United States

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For correspondence: cmccurdy@cop.ufl.edu

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Drug Metabolism and Disposition

Vol. 50, Issue 6

1 Jun 2022

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