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OtherArticle

The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study

Erin C Berthold, Shyam H Kamble, Kanumuri S Raju, Michelle A Kuntz, Alexandria S Senetra, Marco Mottinelli, Francisco León, Luis F Restrepo, Avi Patel, Nicholas P Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy
Drug Metabolism and Disposition November 10, 2021, DMD-AR-2021-000640; DOI: https://doi.org/10.1124/dmd.121.000640
Erin C Berthold
1Pharmaceutics, University of Florida, United States
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  • ORCID record for Erin C Berthold
Shyam H Kamble
2Pharmaceutics, University of Florida College of Pharmacy, United States
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Kanumuri S Raju
2Pharmaceutics, University of Florida College of Pharmacy, United States
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Michelle A Kuntz
2Pharmaceutics, University of Florida College of Pharmacy, United States
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Alexandria S Senetra
1Pharmaceutics, University of Florida, United States
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Marco Mottinelli
3Medicinal Chemistry, College of Pharmacy, University of Florida, United States
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Francisco León
3Medicinal Chemistry, College of Pharmacy, University of Florida, United States
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Luis F Restrepo
4Pharmacodynamics, College of Pharmacy, University of Florida, United States
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Avi Patel
4Pharmacodynamics, College of Pharmacy, University of Florida, United States
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Nicholas P Ho
5Pharmacodynamics, University of Florida College of Pharmacy, United States
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Takato Hiranita
4Pharmacodynamics, College of Pharmacy, University of Florida, United States
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Abhisheak Sharma
1Pharmaceutics, University of Florida, United States
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  • For correspondence: cmccurdy@cop.ufl.edu
Lance R. McMahon
6Pharmacology, University of Florida, United States
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Christopher R. McCurdy
7College of Pharmacy, University of Florida, United States
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  • For correspondence: cmccurdy@cop.ufl.edu
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      Table S1. Validation parameters of UPLC/MS-MS method implemented for the analysis of MTG and 7HMG in various biomatrices
      Table S2. Blood to plasma ratio for MTG and 7HMG
      Table S3. Statistical analyses of baseline values for hotplate response latency and locomotor activity counts
      Table S4. Statistical analyses of effects of MTG and 7HMG on hotplate response latency and locomotor activity counts

      Table S5. Tissue pharmacokinetic parameters of MTG in mice following a single oral dose of 165 mg/kg
      Table S6. Tissue pharmacokinetic parameters of 7HMG in mice following a single oral dose of 50 mg/kg
      Table S7. PK/PD model parameters for MTG and 7HMG
      Figure S1. Tissue concentration time profiles of MTG after single oral dose of 165 mg/kg
      Figure S2. Tissue concentration time profiles of 7HMG after single oral dose of 50 mg/kg
      Figure S3. Goodness of fit plots for the PK/PD models of MTG and 7HMG

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Drug Metabolism and Disposition: 50 (6)
Drug Metabolism and Disposition
Vol. 50, Issue 6
1 Jun 2022
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OtherArticle

7-OH mitragynine alone cannot explain mitragynine analgesia

Erin C Berthold, Shyam H Kamble, Kanumuri S Raju, Michelle A Kuntz, Alexandria S Senetra, Marco Mottinelli, Francisco León, Luis F Restrepo, Avi Patel, Nicholas P Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy
Drug Metabolism and Disposition November 10, 2021, DMD-AR-2021-000640; DOI: https://doi.org/10.1124/dmd.121.000640

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OtherArticle

7-OH mitragynine alone cannot explain mitragynine analgesia

Erin C Berthold, Shyam H Kamble, Kanumuri S Raju, Michelle A Kuntz, Alexandria S Senetra, Marco Mottinelli, Francisco León, Luis F Restrepo, Avi Patel, Nicholas P Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy
Drug Metabolism and Disposition November 10, 2021, DMD-AR-2021-000640; DOI: https://doi.org/10.1124/dmd.121.000640
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