Data Supplement

• Supplemental Data -

  Table S1. Validation parameters of UPLC/MS-MS method implemented for the analysis of MTG and 7HMG in various biomatrices
  Table S2. Blood to plasma ratio for MTG and 7HMG
  Table S3. Statistical analyses of baseline values for hotplate response latency and locomotor activity counts
  Table S4. Statistical analyses of effects of MTG and 7HMG on hotplate response latency and locomotor activity counts

  Table S5. Tissue pharmacokinetic parameters of MTG in mice following a single oral dose of 165 mg/kg
  Table S6. Tissue pharmacokinetic parameters of 7HMG in mice following a single oral dose of 50 mg/kg
  Table S7. PK/PD model parameters for MTG and 7HMG
  Figure S1. Tissue concentration time profiles of MTG after single oral dose of 165 mg/kg
  Figure S2. Tissue concentration time profiles of 7HMG after single oral dose of 50 mg/kg
  Figure S3. Goodness of fit plots for the PK/PD models of MTG and 7HMG