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CYP2C19 plays a major role in the hepatic N-oxidation of cotinine

Yadira X Perez-Paramo, Christy J.W. Watson, Gang Chen and Philip Lazarus
Drug Metabolism and Disposition February 23, 2022, DMD-AR-2021-000624; DOI: https://doi.org/10.1124/dmd.121.000624

Article Information

DMD-AR-2021-000624
DOI 
https://doi.org/10.1124/dmd.121.000624
PubMed 
35197312
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Published online February 23, 2022.

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© 2020 The Authors. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited and is not used for commercial purposes.

Author Information

  1. Yadira X Perez-Paramo1,
  2. Christy J.W. Watson2,
  3. Gang Chen3, and
  4. Philip Lazarus4,*
  1. 1OMNI-Biomarker Development, Genentech Inc., United States
  2. 2Pharmaceutical Sciences, Washington State University, United States
  3. 3Pharmaceutical Sciences, WSU College of Pharmacy, United States
  4. 4Pharmaceutical Sciences, Washington State University College of Pharmacy, United States
  1. ↵* Corresponding Author:
    Philip Lazarus, Pharmaceutical Sciences, Washington State University College of Pharmacy, Riverpoint Drive, Spokane, 99212, United States. E-mail: phil.lazarus{at}wsu.edu

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CYP2C19 variants and cotinine-N-oxide metabolism

Yadira X Perez-Paramo, Christy J.W. Watson, Gang Chen and Philip Lazarus
Drug Metabolism and Disposition February 23, 2022, DMD-AR-2021-000624; DOI: https://doi.org/10.1124/dmd.121.000624
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