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Label-Free but Still Constrained: Assessment of Global Proteomic Strategies for the Quantification of Hepatic Enzymes and Transporters

Jill Barber, Zubida M. Al-Majdoub, Narciso Couto, Areti-Maria Vasilogianni, Annika Tillmann, Sarah Alrubia, Amin Rostami-Hodjegan and Brahim Achour
Drug Metabolism and Disposition March 20, 2022, DMD-AR-2021-000780; DOI: https://doi.org/10.1124/dmd.121.000780
Jill Barber
1Pharmacy and Pharmaceutical Sciences, University of Manchester, United Kingdom
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Zubida M. Al-Majdoub
2Division of Pharmacy and Optometry, University of Manchester, United Kingdom
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Narciso Couto
3Department of Chemical and Biological Engineering, University of Sheffield, United Kingdom
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Areti-Maria Vasilogianni
4University of Manchester, United Kingdom
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Annika Tillmann
5Centre for Applied Pharmacokinetic Research, University of Manchester, United Kingdom
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Sarah Alrubia
5Centre for Applied Pharmacokinetic Research, University of Manchester, United Kingdom
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Amin Rostami-Hodjegan
6Systems Pharmacology, Manchester Pharmacy School, University of Manchester, United Kingdom
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  • ORCID record for Amin Rostami-Hodjegan
Brahim Achour
5Centre for Applied Pharmacokinetic Research, University of Manchester, United Kingdom
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  • For correspondence: brahim.achour@manchester.ac.uk
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Article Information

DMD-AR-2021-000780
DOI 
https://doi.org/10.1124/dmd.121.000780
PubMed 
35307650

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Published online March 20, 2022.

Article Versions

  • You are currently viewing an Earlier version of this article (March 20, 2022 - 05:39).
  • View the most recent version of this article
Copyright & Usage 
Copyright © 2020 American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Jill Barber1,
  2. Zubida M. Al-Majdoub2,
  3. Narciso Couto3,
  4. Areti-Maria Vasilogianni4,
  5. Annika Tillmann5,
  6. Sarah Alrubia5,
  7. Amin Rostami-Hodjegan6, and
  8. Brahim Achour5,*
  1. 1Pharmacy and Pharmaceutical Sciences, University of Manchester, United Kingdom
  2. 2Division of Pharmacy and Optometry, University of Manchester, United Kingdom
  3. 3Department of Chemical and Biological Engineering, University of Sheffield, United Kingdom
  4. 4University of Manchester, United Kingdom
  5. 5Centre for Applied Pharmacokinetic Research, University of Manchester, United Kingdom
  6. 6Systems Pharmacology, Manchester Pharmacy School, University of Manchester, United Kingdom
  1. ↵* Corresponding Author:
    Brahim Achour, Centre for Applied Pharmacokinetic Research, University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, United Kingdom. E-mail: brahim.achour{at}manchester.ac.uk

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Drug Metabolism and Disposition: 51 (4)
Drug Metabolism and Disposition
Vol. 51, Issue 4
1 Apr 2023
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Critique of Label-Free Proteomics of Pharmacokinetic Targets

Jill Barber, Zubida M. Al-Majdoub, Narciso Couto, Areti-Maria Vasilogianni, Annika Tillmann, Sarah Alrubia, Amin Rostami-Hodjegan and Brahim Achour
Drug Metabolism and Disposition March 20, 2022, DMD-AR-2021-000780; DOI: https://doi.org/10.1124/dmd.121.000780

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Critique of Label-Free Proteomics of Pharmacokinetic Targets

Jill Barber, Zubida M. Al-Majdoub, Narciso Couto, Areti-Maria Vasilogianni, Annika Tillmann, Sarah Alrubia, Amin Rostami-Hodjegan and Brahim Achour
Drug Metabolism and Disposition March 20, 2022, DMD-AR-2021-000780; DOI: https://doi.org/10.1124/dmd.121.000780
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