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Characterizing and Quantifying Extrahepatic Metabolism of (-)-∆9-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, 11-OH-THC

Aditya R. Kumar, Gabriela I. Patilea-Vrana, Olena Anoshchenko and Jashvant D. Unadkat
Drug Metabolism and Disposition April 3, 2022, DMD-AR-2022-000868; DOI: https://doi.org/10.1124/dmd.122.000868
Aditya R. Kumar
1Pharmaceutics, University of Washington, United States
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Gabriela I. Patilea-Vrana
2Seagen, United States
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Olena Anoshchenko
1Pharmaceutics, University of Washington, United States
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Jashvant D. Unadkat
1Pharmaceutics, University of Washington, United States
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      Supplemental Table 1: Demographics of the Human Placentae

      Supplemental Table 2: Demographics of Human Fetal Livers

      Supplemental Table 3: LC-MS/MS parameters of drug quantification

      Supplemental Figure 1: Formation of resorufin from 7-ethoxyresorufin in pooled human adult lung microsomes (cigarette smokers).

      Supplemental Figure 2: Formation of β-Estradiol (CYP19) from testosterone in human T2 and term placental microsomes.

      Supplemental Figure 3: Formation of 1-OH-MDZ from MDZ in pooled human fetal liver microsomes.

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Drug Metabolism and Disposition: 50 (6)
Drug Metabolism and Disposition
Vol. 50, Issue 6
1 Jun 2022
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Kinetics of THC and 11-OH-THC Extrahepatic Metabolism

Aditya R. Kumar, Gabriela I. Patilea-Vrana, Olena Anoshchenko and Jashvant D. Unadkat
Drug Metabolism and Disposition April 3, 2022, DMD-AR-2022-000868; DOI: https://doi.org/10.1124/dmd.122.000868

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Kinetics of THC and 11-OH-THC Extrahepatic Metabolism

Aditya R. Kumar, Gabriela I. Patilea-Vrana, Olena Anoshchenko and Jashvant D. Unadkat
Drug Metabolism and Disposition April 3, 2022, DMD-AR-2022-000868; DOI: https://doi.org/10.1124/dmd.122.000868
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