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Examining Physiologically-Based Pharmacokinetic (PBPK) Model Assumptions for Cross-Tissue Similarity of Kcat: The Case Example of Uridine 5'-diphosphate Glucuronosyltransferase (UGT)

Anika N Ahmed, Amin Rostami-Hodjegan, Jill Barber and Zubida M. Al-Majdoub
Drug Metabolism and Disposition May 30, 2022, DMD-COM-2021-000813; DOI: https://doi.org/10.1124/dmd.121.000813

Article Information

DMD-COM-2021-000813
DOI 
https://doi.org/10.1124/dmd.121.000813
PubMed 
35636771
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Published online May 30, 2022.

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Copyright © 2020 American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Anika N Ahmed1,
  2. Amin Rostami-Hodjegan2,
  3. Jill Barber3, and
  4. Zubida M. Al-Majdoub4,*
  1. 1Centre for Applied Pharmacokinetic Research,, The University of Manchester, United Kingdom
  2. 2Systems Pharmacology, Manchester Pharmacy School, University of Manchester, United Kingdom
  3. 3Pharmacy and Pharmaceutical Sciences, University of Manchester, United Kingdom
  4. 4Division of Pharmacy and Optometry, University of Manchester, United Kingdom
  1. ↵* Corresponding Author:
    Zubida M. Al-Majdoub, Division of Pharmacy and Optometry, University of Manchester, Centre for Applied Pharmacokinetic Research, Division of Pharmacy and Optometry | School of Health Sciences, Stopford Building, Manchester, M13 9PT, United Kingdom. E-mail: zubida.al-majdoub{at}manchester.ac.uk

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Article usage: May 2022 to January 2023

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Jun 202247523207
Jul 2022133150
Aug 20223595761
Sep 20222311228
Oct 202287712
Nov 202298813
Dec 2022851015
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Kcat assessment of UGT enzymes across different organs.

Anika N Ahmed, Amin Rostami-Hodjegan, Jill Barber and Zubida M. Al-Majdoub
Drug Metabolism and Disposition May 30, 2022, DMD-COM-2021-000813; DOI: https://doi.org/10.1124/dmd.121.000813
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