Examining Physiologically-Based Pharmacokinetic (PBPK) Model Assumptions for Cross-Tissue Similarity of Kcat: The Case Example of Uridine 5'-diphosphate Glucuronosyltransferase (UGT)

Anika N Ahmed; Amin Rostami-Hodjegan; Jill Barber; Zubida M. Al-Majdoub

doi:10.1124/dmd.121.000813

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Examining Physiologically-Based Pharmacokinetic (PBPK) Model Assumptions for Cross-Tissue Similarity of K_cat: The Case Example of Uridine 5'-diphosphate Glucuronosyltransferase (UGT)

Anika N Ahmed, Amin Rostami-Hodjegan, Jill Barber and Zubida M. Al-Majdoub

Drug Metabolism and Disposition May 30, 2022, DMD-COM-2021-000813; DOI: https://doi.org/10.1124/dmd.121.000813

Anika N Ahmed

1Centre for Applied Pharmacokinetic Research,, The University of Manchester, United Kingdom

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Amin Rostami-Hodjegan

2Systems Pharmacology, Manchester Pharmacy School, University of Manchester, United Kingdom

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ORCID record for Amin Rostami-Hodjegan

Jill Barber

3Pharmacy and Pharmaceutical Sciences, University of Manchester, United Kingdom

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Zubida M. Al-Majdoub

4Division of Pharmacy and Optometry, University of Manchester, United Kingdom

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ORCID record for Zubida M. Al-Majdoub
For correspondence: zubida.al-majdoub@manchester.ac.uk

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Drug Metabolism and Disposition

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K_cat assessment of UGT enzymes across different organs.

Anika N Ahmed, Amin Rostami-Hodjegan, Jill Barber and Zubida M. Al-Majdoub

Drug Metabolism and Disposition May 30, 2022, DMD-COM-2021-000813; DOI: https://doi.org/10.1124/dmd.121.000813

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K_cat assessment of UGT enzymes across different organs.

Anika N Ahmed, Amin Rostami-Hodjegan, Jill Barber and Zubida M. Al-Majdoub

Drug Metabolism and Disposition May 30, 2022, DMD-COM-2021-000813; DOI: https://doi.org/10.1124/dmd.121.000813

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Examining Physiologically-Based Pharmacokinetic (PBPK) Model Assumptions for Cross-Tissue Similarity of K_cat: The Case Example of Uridine 5'-diphosphate Glucuronosyltransferase (UGT)

K_cat assessment of UGT enzymes across different organs.

K_cat assessment of UGT enzymes across different organs.