Data Supplement

• Supplemental Figures -

  Supplementary Figure 1.   Mean plasma concentrations of LCA (A), CA (B), and DCA (C) before (Day -4 and Day -2),
  during (Day 1 to Day 8), and one day after (Day 9) administration of CDCA (50 and 100 mg/kg/day) in three male cynomolgus monkeys. Data are shown as the mean and SD values.
  

  Supplementary Figure 2.  Mean plasma concentrations of LCA (A), CA (B), and DCA (C) on Day 1 after the first vehicle
  (blue closed squares), 50 mpk CDCA (red closed triangles), or 100 mpk CDCA dose (black closed circles), and on Day 8 after the eighth vehicle (blue open squares), 50 mpk CDCA (red open triangles), or 100 mpk CDCA dose (black open circles) are shown as mean and SD values.
  

  Supplementary Figure 3.  Effects of CDCA and RIF treatments on the liver concentrations of CPI (A), CPIII (B), CDCA
  (C), LCA (D), CA (E), and DCA (F) of cynomolgus monkeys.