Data Supplement

• Supplemental Data  -

  Supplemental Figure S1: Cell Viability Studies in Plated Rat Hepatocytes.

  Supplemental Figure S2: Proton NMR Spectrum of JNJ-2482272.

  Supplemental Figure S3: Proton NMR Spectrum of M4.

  Supplemental Figure S4: Proton NMR Spectrum of M5.

  Supplemental Figure S5: Cell Viability Studies in Human Reporter Cell Lines.

  Supplemental Figure S6: Induction of P450 Gene Expression in Pooled Human Donor Hepatocytes.

   Supplemental Figure S7: Induction of CYP1A and CYP3A Activity in Pooled Human Donor Hepatocytes.

  Supplemental Figure S8: Quantum Mechanic Dihedral Scan of JNJ-2482272.

  Supplemental Table S1: Cell Viability Studies in Plated Primary Human Hepatocytes

  Supplemental Table S2: JNJ-2482272 P450 Inhibition in Human Liver Microsomes