The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans

Jonathan N. Bauman; Angela C. Doran; Amanda King-Ahmad; Raman Sharma; Gregory S. Walker; Jian Lin; Tsung H Lin; Jean-Baptiste Telliez; Sakambari Tripathy; Theunis C. Goosen; Christopher Banfield; Bimal K Malhotra; Martin E Dowty

doi:10.1124/dmd.122.000829

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The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans

Jonathan N. Bauman, Angela C. Doran, Amanda King-Ahmad, Raman Sharma, Gregory S. Walker, Jian Lin, Tsung H Lin, Jean-Baptiste Telliez, Sakambari Tripathy, Theunis C. Goosen, Christopher Banfield, Bimal K Malhotra and Martin E Dowty

Drug Metabolism and Disposition June 14, 2022, DMD-AR-2022-000829; DOI: https://doi.org/10.1124/dmd.122.000829

Jonathan N. Bauman

1PDM, Pfizer Global R&D, United States

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Angela C. Doran

2Medicine Design - ADME Sciences, Pfizer, United States

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Amanda King-Ahmad

3Medicine Design, Pfizer Inc, United States

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Raman Sharma

4PDM Biotransformation, Pfizer, United States

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Gregory S. Walker

5PDM, Pfizer, United States

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Jian Lin

6PDM, Pfizer Inc, United States

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Tsung H Lin

7Inflammation and Immunology, Pfizer Inc, United States

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Jean-Baptiste Telliez

7Inflammation and Immunology, Pfizer Inc, United States

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Sakambari Tripathy

8Clinical Pharmacology, Pfizer Inc, United States

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Theunis C. Goosen

9Pharmacokinetics, Dynamics & Metabolism, Pfizer, Inc, United States

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Christopher Banfield

8Clinical Pharmacology, Pfizer Inc, United States

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Bimal K Malhotra

8Clinical Pharmacology, Pfizer Inc, United States

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Martin E Dowty

10Pfizer Inc, United States

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ORCID record for Martin E Dowty
For correspondence: martin.dowty@pfizer.com

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Drug Metabolism and Disposition

Vol. 51, Issue 2

1 Feb 2023

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