The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans

Jonathan N. Bauman; Angela C. Doran; Amanda King-Ahmad; Raman Sharma; Gregory S. Walker; Jian Lin; Tsung H Lin; Jean-Baptiste Telliez; Sakambari Tripathy; Theunis C. Goosen; Christopher Banfield; Bimal K Malhotra; Martin E Dowty

doi:10.1124/dmd.122.000829

OtherArticle

The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans

Jonathan N. Bauman, Angela C. Doran, Amanda King-Ahmad, Raman Sharma, Gregory S. Walker, Jian Lin, Tsung H Lin, Jean-Baptiste Telliez, Sakambari Tripathy, Theunis C. Goosen, Christopher Banfield, Bimal K Malhotra and Martin E Dowty

Drug Metabolism and Disposition June 14, 2022, DMD-AR-2022-000829; DOI: https://doi.org/10.1124/dmd.122.000829

Jonathan N. Bauman

1PDM, Pfizer Global R&D, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Angela C. Doran

2Medicine Design - ADME Sciences, Pfizer, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Amanda King-Ahmad

3Medicine Design, Pfizer Inc, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Raman Sharma

4PDM Biotransformation, Pfizer, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Gregory S. Walker

5PDM, Pfizer, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jian Lin

6PDM, Pfizer Inc, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Tsung H Lin

7Inflammation and Immunology, Pfizer Inc, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Jean-Baptiste Telliez

7Inflammation and Immunology, Pfizer Inc, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Sakambari Tripathy

8Clinical Pharmacology, Pfizer Inc, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Theunis C. Goosen

9Pharmacokinetics, Dynamics & Metabolism, Pfizer, Inc, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Christopher Banfield

8Clinical Pharmacology, Pfizer Inc, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Bimal K Malhotra

8Clinical Pharmacology, Pfizer Inc, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site

Martin E Dowty

10Pfizer Inc, United States

Find this author on Google Scholar
Find this author on PubMed
Search for this author on this site
ORCID record for Martin E Dowty
For correspondence: martin.dowty@pfizer.com

Article
Figures & Data
Info & Metrics
eLetters
PDF + SI
PDF

Submit a Response to This Article

Compose eLetter

Title *

Contents

More information about text formats

Plain text

No HTML tags allowed.
Web page addresses and e-mail addresses turn into links automatically.
Lines and paragraphs break automatically.

Author Information

Contributors
First Name and Middle Initial * First or given name, e.g. 'Peter'. Last Name * Your last, or family, name, e.g. 'MacMoody'. Email Address * Your email address, e.g. higgs-boson@gmail.com Occupation * Your role and/or occupation, e.g. 'Orthopedic Surgeon'. Affiliation * Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.

Statement of Competing Interests

Competing interests? *

Yes

Please describe the competing interests

Vertical Tabs

Jump to comment:

No eLetters have been published for this article.

PreviousNext

In this issue

Drug Metabolism and Disposition

Vol. 50, Issue 6

1 Jun 2022

Table of Contents
About the Cover
Index by author

Download PDF

Article Alerts

User Name *

Password *

Email *

Email Article

Thank you for sharing this Drug Metabolism & Disposition article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Your Email *

Your Name *

Send To *

Enter multiple addresses on separate lines or separate them with commas.

You are going to email the following The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans

Message Subject (Your Name) has forwarded a page to you from Drug Metabolism & Disposition

Message Body (Your Name) thought you would be interested in this article in Drug Metabolism & Disposition.

Your Personal Message

CAPTCHA

This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Citation Tools

OtherArticle