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Physiologically based pharmacokinetic modeling for quantitative prediction of exposure to a human disproportionate metabolite of the selective Nav1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase, using chimeric mice with humanized liver
Daigo Asano, Koichi Nakamura, Yumi Nishiya, Hideyuki Shiozawa, Hideo Takakusa, Takahiro Shibayama, Shin-ichi Inoue, Tsuyoshi Shinozuka, Takakazu Hamada, Chizuko Yahara, Nobuaki Watanabe and Kouichi Yoshinari
Drug Metabolism and Disposition October 23, 2022, DMD-AR-2022-001000; DOI: https://doi.org/10.1124/dmd.122.001000
Daigo Asano
1Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Japan
Koichi Nakamura
1Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Japan
Yumi Nishiya
2Drug Metabolism&Pharacokinetics Research Labo, Daiichi Sankyo Co. Ltd., Japan
Hideyuki Shiozawa
3Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Japan
Hideo Takakusa
4Drug Metabolism & Pharmacokinetics Research Laboratories, Daiichi-Sankyo Co., Ltd., Japan
Takahiro Shibayama
3Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Japan
Shin-ichi Inoue
3Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Japan
Tsuyoshi Shinozuka
5R&D Planning & Management Department, Daiichi Sankyo Co., Ltd., Japan
Takakazu Hamada
6Research function, Daiichi Sankyo Co., Ltd., Japan
Chizuko Yahara
7Daiichi Sankyo Co., Ltd., Japan
Nobuaki Watanabe
3Drug Metabolism and Pharmacokinetics Research Laboratories, Daiichi Sankyo Co., Ltd., Japan
Kouichi Yoshinari
8School of Pharmaceutical Sciences, University of Shizuoka, Japan

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In this issue
Drug Metabolism and Disposition
Vol. 51, Issue 2
1 Feb 2023
OtherArticle
PBPK modeling of a human disproportionate metabolite
Daigo Asano, Koichi Nakamura, Yumi Nishiya, Hideyuki Shiozawa, Hideo Takakusa, Takahiro Shibayama, Shin-ichi Inoue, Tsuyoshi Shinozuka, Takakazu Hamada, Chizuko Yahara, Nobuaki Watanabe and Kouichi Yoshinari
Drug Metabolism and Disposition October 23, 2022, DMD-AR-2022-001000; DOI: https://doi.org/10.1124/dmd.122.001000
OtherArticle
PBPK modeling of a human disproportionate metabolite
Daigo Asano, Koichi Nakamura, Yumi Nishiya, Hideyuki Shiozawa, Hideo Takakusa, Takahiro Shibayama, Shin-ichi Inoue, Tsuyoshi Shinozuka, Takakazu Hamada, Chizuko Yahara, Nobuaki Watanabe and Kouichi Yoshinari
Drug Metabolism and Disposition October 23, 2022, DMD-AR-2022-001000; DOI: https://doi.org/10.1124/dmd.122.001000
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