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A physiological-based pharmacokinetic model embedded with a target-mediated drug disposition mechanism can characterize single dose warfarin pharmacokinetic profiles in subjects with various CYP2C9 genotypes under different co-treatments

Shen Cheng, Darcy R Flora, Allan E. Rettie, Richard C. Brundage and Timothy S. Tracy
Drug Metabolism and Disposition November 15, 2022, DMD-AR-2022-001048; DOI: https://doi.org/10.1124/dmd.122.001048
Shen Cheng
1present affiliation: Metrum Research Group, United States
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Darcy R Flora
2Present Affiliation: GRYT Health Inc., United States
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Allan E. Rettie
3Dept. of Medicinal Chemistry, University of Washington, United States
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Richard C. Brundage
4Experimental and Clinical Pharmacology, University of Minnesota, United States
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  • ORCID record for Richard C. Brundage
  • For correspondence: brund001@umn.edu
Timothy S. Tracy
5Tracy Consultants, United States
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Article Information

DMD-AR-2022-001048
DOI 
https://doi.org/10.1124/dmd.122.001048
PubMed 
36379708

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Published online November 15, 2022.

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  • You are currently viewing an Earlier version of this article (November 15, 2022 - 10:57).
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Copyright & Usage 
Copyright © 2020 American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Shen Cheng1,
  2. Darcy R Flora2,
  3. Allan E. Rettie3,
  4. Richard C. Brundage4,*, and
  5. Timothy S. Tracy5
  1. 1present affiliation: Metrum Research Group, United States
  2. 2Present Affiliation: GRYT Health Inc., United States
  3. 3Dept. of Medicinal Chemistry, University of Washington, United States
  4. 4Experimental and Clinical Pharmacology, University of Minnesota, United States
  5. 5Tracy Consultants, United States
  1. ↵* Corresponding Author:
    Richard C. Brundage, Experimental and Clinical Pharmacology, University of Minnesota, 717 Delaware St. SE, Room 464, Minneapolis, Minnesota, 55414, United States. E-mail: brund001{at}umn.edu

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Feb 202310957

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Drug Metabolism and Disposition: 51 (2)
Drug Metabolism and Disposition
Vol. 51, Issue 2
1 Feb 2023
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OtherArticle

Warfarin PBPK model with TMDD mechanism

Shen Cheng, Darcy R Flora, Allan E. Rettie, Richard C. Brundage and Timothy S. Tracy
Drug Metabolism and Disposition November 15, 2022, DMD-AR-2022-001048; DOI: https://doi.org/10.1124/dmd.122.001048

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OtherArticle

Warfarin PBPK model with TMDD mechanism

Shen Cheng, Darcy R Flora, Allan E. Rettie, Richard C. Brundage and Timothy S. Tracy
Drug Metabolism and Disposition November 15, 2022, DMD-AR-2022-001048; DOI: https://doi.org/10.1124/dmd.122.001048
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