Data Supplement

• Supplemental Data -

  Supplemental Table 1. Comparison of CYP3A4 mRNA induction in human hepatocytes and PXR activation in DPX2 cells.

  Supplemental Table 2. Input parameters for the static induction risk assessment with F2 method.

  Supplemental Figure 1. Representative qualification results of human hepatocyte batches for CYP2B6 and CYP3A4 mRNA induction.

  Supplemental Figure 2. Predicted versus observed AUC reduction (%) of the probe CYP3A4 substrate (including pleconaril and bosentan).