Article Figures & Data
Additional Files
Data Supplement
- Supplemental Data -
Supplemental Figure 1. Activity of UGT2B10 and UGT1A4 enzyme preparations in the metabolism of RO5263397/6 and Medetomidine.
Supplemental Table 1. Measured Intrinsic Clearances of Medetomidine, RO5263397, Propranolol and Testosterone in Liver Microsomes without BSA Supplementation.
Supplemental Table 2. Measured (Bound) intrinsic Clearance and Calculated Unbound Intrinsic Clearances of Medetomidine, RO5263397, Propranolol and Testosterone in Incubations with Pooled HLM in presence and absence of BSA.
Supplemental Table 3. Glucuronide formation ratio of S and R propranolol in presence and absence of BSA in HLM , HIM, and HKM.
Supplemental Table 4. MS/MS parameters and retention time for all enantiomers.
Supplemental Table 5. Chromatography programs of all enantiopairs.
- Supplemental Data -