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Antibiotics-induced depletion of rat microbiota induces changes in the expression of host drug-processing genes and pharmacokinetic behaviors of CYPs probe drugs

Haijun Yang, Yanjuan Zhang, Rong Zhou, Tianyuan Wu, Peng Zhu, Yujie Liu, Jian Zhou, Yalan Xiong, Yanling Xiong, Honghao Zhou, Wei Zhang, Yan Shu, Xiong Li and Qing Li
Drug Metabolism and Disposition January 9, 2023, DMD-AR-2022-001173; DOI: https://doi.org/10.1124/dmd.122.001173
Haijun Yang
1Department of Clinical Pharmacology, Xiangya Hospital Central South University, China
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Yanjuan Zhang
2Central South University, China
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Rong Zhou
1Department of Clinical Pharmacology, Xiangya Hospital Central South University, China
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Tianyuan Wu
1Department of Clinical Pharmacology, Xiangya Hospital Central South University, China
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Peng Zhu
1Department of Clinical Pharmacology, Xiangya Hospital Central South University, China
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Yujie Liu
1Department of Clinical Pharmacology, Xiangya Hospital Central South University, China
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Jian Zhou
2Central South University, China
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Yalan Xiong
2Central South University, China
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Yanling Xiong
2Central South University, China
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Honghao Zhou
3Institute of Clinical Pharmacology, China
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Wei Zhang
2Central South University, China
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Yan Shu
4Pharmaceutical Sciences, University of Maryland, United States
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  • ORCID record for Yan Shu
Xiong Li
5Key Specialty of Clinical Pharmacy, The First Affiliated Hospital of Guangdong Pharmaceutical University, China
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Qing Li
1Department of Clinical Pharmacology, Xiangya Hospital Central South University, China
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  • For correspondence: liqing9251026@csu.edu.cn
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Article Information

DMD-AR-2022-001173
DOI 
https://doi.org/10.1124/dmd.122.001173
PubMed 
36623881

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Published online January 9, 2023.

Article Versions

  • You are currently viewing an Earlier version of this article (January 9, 2023 - 08:26).
  • View the most recent version of this article
Copyright & Usage 
Copyright © 2020 American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Haijun Yang1,
  2. Yanjuan Zhang2,
  3. Rong Zhou1,
  4. Tianyuan Wu1,
  5. Peng Zhu1,
  6. Yujie Liu1,
  7. Jian Zhou2,
  8. Yalan Xiong2,
  9. Yanling Xiong2,
  10. Honghao Zhou3,
  11. Wei Zhang2,
  12. Yan Shu4,
  13. Xiong Li5, and
  14. Qing Li1,*
  1. 1Department of Clinical Pharmacology, Xiangya Hospital Central South University, China
  2. 2Central South University, China
  3. 3Institute of Clinical Pharmacology, China
  4. 4Pharmaceutical Sciences, University of Maryland, United States
  5. 5Key Specialty of Clinical Pharmacy, The First Affiliated Hospital of Guangdong Pharmaceutical University, China
  1. ↵* Corresponding Author:
    Qing Li, Department of Clinical Pharmacology, Xiangya Hospital Central South University, Changsha, N/A, China. E-mail: liqing9251026{at}csu.edu.cn

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Drug Metabolism and Disposition: 51 (3)
Drug Metabolism and Disposition
Vol. 51, Issue 3
1 Mar 2023
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Antibiotics induces changes in the expression of rat DPGs

Haijun Yang, Yanjuan Zhang, Rong Zhou, Tianyuan Wu, Peng Zhu, Yujie Liu, Jian Zhou, Yalan Xiong, Yanling Xiong, Honghao Zhou, Wei Zhang, Yan Shu, Xiong Li and Qing Li
Drug Metabolism and Disposition January 9, 2023, DMD-AR-2022-001173; DOI: https://doi.org/10.1124/dmd.122.001173

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OtherArticle

Antibiotics induces changes in the expression of rat DPGs

Haijun Yang, Yanjuan Zhang, Rong Zhou, Tianyuan Wu, Peng Zhu, Yujie Liu, Jian Zhou, Yalan Xiong, Yanling Xiong, Honghao Zhou, Wei Zhang, Yan Shu, Xiong Li and Qing Li
Drug Metabolism and Disposition January 9, 2023, DMD-AR-2022-001173; DOI: https://doi.org/10.1124/dmd.122.001173
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