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Application of Accelerator Mass Spectrometry to Characterize the Mass Balance Recovery and Disposition of AZD4831, a Novel Myeloperoxidase Inhibitor, Following Administration of an Oral Radiolabeled Microtracer Dose in Humans
Chandrali Bhattacharya, Ann-Sofie Sandinge, Ryan A. Bragg, Maria Heijer, Jingjing Yan, Linda C. Andersson, Ulrik Jurva, Marta Pelay-Gimeno, Wouter H.J. Vaes, Rianne A.F. de Ligt, Malin Gränfors, Carl Amilon, Eva-Lotte Lindstedt, Somasekhara R. Menakuru, Pavlo Garkaviy, Lars Weidolf and V. Sashi Gopaul
Drug Metabolism and Disposition January 13, 2023, DMD-AR-2022-001100; DOI: https://doi.org/10.1124/dmd.122.001100
Chandrali Bhattacharya
1Clinical Pharmacology and Quantitative Pharmacology, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, United States
Ann-Sofie Sandinge
2Drug Metabolism and Pharmacokinetics (DMPK), Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Sweden
Ryan A. Bragg
3Early Chemical Development, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, United Kingdom
Maria Heijer
4Integrated Bioanalysis, Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca, Sweden
Jingjing Yan
5DMPK, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Sweden
Linda C. Andersson
5DMPK, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Sweden
Ulrik Jurva
2Drug Metabolism and Pharmacokinetics (DMPK), Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Sweden
Marta Pelay-Gimeno
6TNO, Netherlands
Wouter H.J. Vaes
7Metabolic Health Research, The Netherlands Organization for Applied Scientific Research (TNO), Netherlands
Rianne A.F. de Ligt
6TNO, Netherlands
Malin Gränfors
8Early Product Development, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Sweden
Carl Amilon
9Formerly of Drug Metabolism and Pharmacokinetics (DMPK), Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM) BioPharmaceuticals R&D, AstraZeneca, Sweden
Eva-Lotte Lindstedt
10Formerly BioPharmaceuticals R&D, AstraZeneca, Sweden
Somasekhara R. Menakuru
11Quotient Sciences, United Kingdom
Pavlo Garkaviy
12Early Clinical Development, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Sweden
Lars Weidolf
13iMed CVMD DMPK, AstraZeneca R&D Molndal, Sweden
V. Sashi Gopaul
14Early Research and Development Cardiovascular Renal and Metabolism, AstraZeneca R&D Gothenburg, Sweden

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OtherArticle
Mass balance recovery and disposition of AZD4831 in humans
Chandrali Bhattacharya, Ann-Sofie Sandinge, Ryan A. Bragg, Maria Heijer, Jingjing Yan, Linda C. Andersson, Ulrik Jurva, Marta Pelay-Gimeno, Wouter H.J. Vaes, Rianne A.F. de Ligt, Malin Gränfors, Carl Amilon, Eva-Lotte Lindstedt, Somasekhara R. Menakuru, Pavlo Garkaviy, Lars Weidolf and V. Sashi Gopaul
Drug Metabolism and Disposition January 13, 2023, DMD-AR-2022-001100; DOI: https://doi.org/10.1124/dmd.122.001100
OtherArticle
Mass balance recovery and disposition of AZD4831 in humans
Chandrali Bhattacharya, Ann-Sofie Sandinge, Ryan A. Bragg, Maria Heijer, Jingjing Yan, Linda C. Andersson, Ulrik Jurva, Marta Pelay-Gimeno, Wouter H.J. Vaes, Rianne A.F. de Ligt, Malin Gränfors, Carl Amilon, Eva-Lotte Lindstedt, Somasekhara R. Menakuru, Pavlo Garkaviy, Lars Weidolf and V. Sashi Gopaul
Drug Metabolism and Disposition January 13, 2023, DMD-AR-2022-001100; DOI: https://doi.org/10.1124/dmd.122.001100
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