Article Figures & Data
Additional Files
Data Supplement
- Supplemental Data -
Supplemental Table S1. Overview of experimental conditions for liquid chromatography-tandem mass spectrometry (LC-MS/MS), liquid chromatography-mass spectrometry (LC-MS), and a high-performance liquid chromatograph equipped with a radiochemical flow detector (Radio-HPLC).
Supplemental Table S2. LC-MS data and proposed product ions of TP0473292, TP0178894, ACA, and ACA-AG observed in the 1-hour incubation mixture of rat, monkey, and human cryopreserved hepatocytes with TP0473292.
Supplemental Table S3. Inhibitory effect of TP0473292, TP0178894, ACA and ACA-AG on the specific activities of cytochrome P450 (CYP) isoforms in human liver microsome in both reversible and time-dependent manner.
Supplemental Table S4. Effect of TP0473292 and TP0178894 on CYP1A2, CYP2B6, and CYP3A4 mRNA expression levels at 10 μM in the primary cultured cryopreserved human hepatocytes.
Supplemental Figure S1. TP0178894 formation rate versus TP0473292 concentration plots in the intestinal (A) and liver (B) S9 fractions.
- Supplemental Data -