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Contribution of UGT enzymes to human drug metabolism stereoselectivity: a case study of medetomidine, RO5263397, propranolol and testosterone

Nicolò Milani, NaHong Qiu and Stephen Fowler
Drug Metabolism and Disposition February 21, 2023, DMD-AR-2022-001024; DOI: https://doi.org/10.1124/dmd.122.001024

Article Information

DMD-AR-2022-001024
DOI 
https://doi.org/10.1124/dmd.122.001024
PubMed 
36810196
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Published online February 21, 2023.

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Copyright & Usage 
Copyright © 2022 American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Nicolò Milani1,
  2. NaHong Qiu2, and
  3. Stephen Fowler3,*
  1. 1Hoffman La Roche, Switzerland
  2. 2Pharmaceutical Research and Early Development, F. Hoffmann-La Roche Ltd, Switzerland
  3. 3Drug Metabolism, F. Hoffmann-La Roche Ltd, Switzerland
  1. ↵* Corresponding Author:
    Stephen Fowler, Drug Metabolism, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, Building 69, Room 114, Basel, N/A, 4070, Switzerland. E-mail: stephen.fowler{at}roche.com

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Article usage: December 2022 to November 2023

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Feb 20234461780
Mar 20235284390
Apr 20231221370
May 20231231237
Jun 2023851934
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Impact of UGT Stereoselectivity on Drug Clearance

Nicolò Milani, NaHong Qiu and Stephen Fowler
Drug Metabolism and Disposition February 21, 2023, DMD-AR-2022-001024; DOI: https://doi.org/10.1124/dmd.122.001024
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