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Metabolism and excretion of therapeutic peptides: current industry practices, perspectives, and recommendations

Minxia Michelle He, Sean Xiaochun Zhu, Joe R Cannon, Jesper Kammersgaard Christensen, Ruchia Duggal, Mithat Gunduz, Constanze Hilgendorf, Adam Hughes, Ivy Kekessie, Maximilian Kullmann, Dennis Leung, Carsten Terjung, Kai Wang and Frank Wesche
Drug Metabolism and Disposition August 17, 2023, DMD-AR-2023-001437; DOI: https://doi.org/10.1124/dmd.123.001437
Minxia Michelle He
1Eli Lilly, United States
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  • For correspondence: xiaochun.zhu@takeda.com
Sean Xiaochun Zhu
2DMPK, Takeda Pharmaceuticals, United States
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  • ORCID record for Sean Xiaochun Zhu
  • For correspondence: xiaochun.zhu@takeda.com
Joe R Cannon
3BMS, United States
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Jesper Kammersgaard Christensen
4Novo Nordisk, Denmark
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Ruchia Duggal
5Merck, United States
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Mithat Gunduz
6Analytical Sciences/Imaging/Biotransformation, Novartis, United States
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Constanze Hilgendorf
7DMPK, AstraZeneca R&D Gothenburg, Sweden
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  • ORCID record for Constanze Hilgendorf
Adam Hughes
8GSK, United Kingdom
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Ivy Kekessie
9Genentech, United States
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Maximilian Kullmann
10Biontech, Germany
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Dennis Leung
9Genentech, United States
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Carsten Terjung
11Bayer, Germany
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Kai Wang
12Janssen Research & Development, United States
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Frank Wesche
13Boehringer Ingelheim Pharma GmbH & Co KG, Germany
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Article Information

DMD-AR-2023-001437
DOI 
https://doi.org/10.1124/dmd.123.001437
PubMed 
37591731

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Published online August 17, 2023.

Article Versions

  • You are currently viewing an Earlier version of this article (August 17, 2023 - 09:20).
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Copyright & Usage 
Copyright © 2023 American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Minxia Michelle He1,*,
  2. Sean Xiaochun Zhu2,*,
  3. Joe R Cannon3,
  4. Jesper Kammersgaard Christensen4,
  5. Ruchia Duggal5,
  6. Mithat Gunduz6,
  7. Constanze Hilgendorf7,
  8. Adam Hughes8,
  9. Ivy Kekessie9,
  10. Maximilian Kullmann10,
  11. Dennis Leung9,
  12. Carsten Terjung11,
  13. Kai Wang12, and
  14. Frank Wesche13
  1. 1Eli Lilly, United States
  2. 2DMPK, Takeda Pharmaceuticals, United States
  3. 3BMS, United States
  4. 4Novo Nordisk, Denmark
  5. 5Merck, United States
  6. 6Analytical Sciences/Imaging/Biotransformation, Novartis, United States
  7. 7DMPK, AstraZeneca R&D Gothenburg, Sweden
  8. 8GSK, United Kingdom
  9. 9Genentech, United States
  10. 10Biontech, Germany
  11. 11Bayer, Germany
  12. 12Janssen Research & Development, United States
  13. 13Boehringer Ingelheim Pharma GmbH & Co KG, Germany
  1. ↵* Corresponding Author:
    Sean Xiaochun Zhu, DMPK, Takeda Pharmaceuticals, 35 Landsdowne St, Cambridge, Massachusetts, 02139, United States. E-mail: xiaochun.zhu{at}takeda.com
  2. * Corresponding Author; email: xiaochun.zhu{at}takeda.com

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Article usage: August 2023 to December 2023

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Oct 2023826100329
Nov 202372259120
Dec 2023721524

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Drug Metabolism and Disposition: 51 (12)
Drug Metabolism and Disposition
Vol. 51, Issue 12
1 Dec 2023
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OtherMinireview

Metabolism and excretion of therapeutic peptides

Minxia Michelle He, Sean Xiaochun Zhu, Joe R Cannon, Jesper Kammersgaard Christensen, Ruchia Duggal, Mithat Gunduz, Constanze Hilgendorf, Adam Hughes, Ivy Kekessie, Maximilian Kullmann, Dennis Leung, Carsten Terjung, Kai Wang and Frank Wesche
Drug Metabolism and Disposition August 17, 2023, DMD-AR-2023-001437; DOI: https://doi.org/10.1124/dmd.123.001437

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OtherMinireview

Metabolism and excretion of therapeutic peptides

Minxia Michelle He, Sean Xiaochun Zhu, Joe R Cannon, Jesper Kammersgaard Christensen, Ruchia Duggal, Mithat Gunduz, Constanze Hilgendorf, Adam Hughes, Ivy Kekessie, Maximilian Kullmann, Dennis Leung, Carsten Terjung, Kai Wang and Frank Wesche
Drug Metabolism and Disposition August 17, 2023, DMD-AR-2023-001437; DOI: https://doi.org/10.1124/dmd.123.001437
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