Metabolism and excretion of therapeutic peptides: current industry practices, perspectives, and recommendations

Minxia Michelle He; Sean Xiaochun Zhu; Joe R Cannon; Jesper Kammersgaard Christensen; Ruchia Duggal; Mithat Gunduz; Constanze Hilgendorf; Adam Hughes; Ivy Kekessie; Maximilian Kullmann; Dennis Leung; Carsten Terjung; Kai Wang; Frank Wesche

doi:10.1124/dmd.123.001437

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Metabolism and excretion of therapeutic peptides: current industry practices, perspectives, and recommendations

Minxia Michelle He, Sean Xiaochun Zhu, Joe R Cannon, Jesper Kammersgaard Christensen, Ruchia Duggal, Mithat Gunduz, Constanze Hilgendorf, Adam Hughes, Ivy Kekessie, Maximilian Kullmann, Dennis Leung, Carsten Terjung, Kai Wang and Frank Wesche

Drug Metabolism and Disposition August 17, 2023, DMD-AR-2023-001437; DOI: https://doi.org/10.1124/dmd.123.001437

Minxia Michelle He

1Eli Lilly, United States

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For correspondence: xiaochun.zhu@takeda.com

Sean Xiaochun Zhu

2DMPK, Takeda Pharmaceuticals, United States

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ORCID record for Sean Xiaochun Zhu
For correspondence: xiaochun.zhu@takeda.com

Joe R Cannon

3BMS, United States

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Jesper Kammersgaard Christensen

4Novo Nordisk, Denmark

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Ruchia Duggal

5Merck, United States

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Mithat Gunduz

6Analytical Sciences/Imaging/Biotransformation, Novartis, United States

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Constanze Hilgendorf

7DMPK, AstraZeneca R&D Gothenburg, Sweden

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Adam Hughes

8GSK, United Kingdom

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Ivy Kekessie

9Genentech, United States

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Maximilian Kullmann

10Biontech, Germany

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Dennis Leung

9Genentech, United States

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Carsten Terjung

11Bayer, Germany

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Kai Wang

12Janssen Research & Development, United States

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Frank Wesche

13Boehringer Ingelheim Pharma GmbH & Co KG, Germany

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Drug Metabolism and Disposition

Vol. 51, Issue 12

1 Dec 2023

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Metabolism and excretion of therapeutic peptides

Drug Metabolism and Disposition August 17, 2023, DMD-AR-2023-001437; DOI: https://doi.org/10.1124/dmd.123.001437

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