3-epi-18β-glycyrrhetinic acid or its glucuronide, the metabolites of glycyrrhizinic acid with individual differences, correlated with diagnostic maker for licorice-induced pseudoaldosteronism in humans

Ryota Sakoda; Kan'ichiro Ishiuchi; Tetsuhiro Yoshino; Yuna Tsunoo; Takao Namiki; Keiko Ogawa-Ochiai; Kiyoshi Minamizawa; Koichi Fukunaga; Kenji Watanabe; Toshiaki Makino

doi:10.1124/dmd.124.001840

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3-epi-18β-glycyrrhetinic acid or its glucuronide, the metabolites of glycyrrhizinic acid with individual differences, correlated with diagnostic maker for licorice-induced pseudoaldosteronism in humans

Ryota Sakoda, Kan'ichiro Ishiuchi, Tetsuhiro Yoshino, Yuna Tsunoo, Takao Namiki, Keiko Ogawa-Ochiai, Kiyoshi Minamizawa, Koichi Fukunaga, Kenji Watanabe and Toshiaki Makino

Drug Metabolism and Disposition September 16, 2024, DMD-AR-2024-001840; DOI: https://doi.org/10.1124/dmd.124.001840

Ryota Sakoda

1Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan

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Kan'ichiro Ishiuchi

1Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan

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For correspondence: makino@phar.nagoya-cu.ac.jp

Tetsuhiro Yoshino

2Center for Kampo Medicine, Keio University School of Medicine, Japan

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ORCID record for Tetsuhiro Yoshino

Yuna Tsunoo

3Department of Pharmacognosy, Nagoya City University, Japan

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Takao Namiki

4Chiba University, Japan

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Keiko Ogawa-Ochiai

5Kampo Clinical Center, Hiroshima University, Japan

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Kiyoshi Minamizawa

6Kameda Medical Center, Japan

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Koichi Fukunaga

7Keio University School of Medicine, Japan

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Kenji Watanabe

7Keio University School of Medicine, Japan

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Toshiaki Makino

1Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan

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ORCID record for Toshiaki Makino
For correspondence: makino@phar.nagoya-cu.ac.jp

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Supplemental Figure S1. Relationships between the serum and urine concentrations of glycyrrhizinic acid (GL) metabolites.

Supplemental Figure S2. Relationships between each metabolite of glycyrrhizinic acid (GL) and pseudoaldosteronism (PsA) markers.

Supplemental Table S1. Donor information of pooled human kidney microsome product shown in the package insert.

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Drug Metabolism and Disposition

Vol. 52, Issue 10

1 Oct 2024

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Individual difference and pseudoaldosteronism by licorice

Ryota Sakoda, Kan'ichiro Ishiuchi, Tetsuhiro Yoshino, Yuna Tsunoo, Takao Namiki, Keiko Ogawa-Ochiai, Kiyoshi Minamizawa, Koichi Fukunaga, Kenji Watanabe and Toshiaki Makino

Drug Metabolism and Disposition September 16, 2024, DMD-AR-2024-001840; DOI: https://doi.org/10.1124/dmd.124.001840

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Individual difference and pseudoaldosteronism by licorice

Ryota Sakoda, Kan'ichiro Ishiuchi, Tetsuhiro Yoshino, Yuna Tsunoo, Takao Namiki, Keiko Ogawa-Ochiai, Kiyoshi Minamizawa, Koichi Fukunaga, Kenji Watanabe and Toshiaki Makino

Drug Metabolism and Disposition September 16, 2024, DMD-AR-2024-001840; DOI: https://doi.org/10.1124/dmd.124.001840

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3-epi-18β-glycyrrhetinic acid or its glucuronide, the metabolites of glycyrrhizinic acid with individual differences, correlated with diagnostic maker for licorice-induced pseudoaldosteronism in humans

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