Data Supplement

• Supplemental Data -

  Supplemental Materials and Methods. LC-MS/MS method to quantify CYP activity.
  

• Supplemental Figure 1 -

  Supplemental Figure S1. Cytokine concentration-response curves for regulation of CYP3A4, CYP2C9, CYP1A2, CYP2C19, FMO3 and UGT2B7 expression and activity by IL-6 (A) and IL-1β (B).

• Supplemental Figure 2 -

  Supplemental Figure S2. Basal mRNA expression levels of DME regulating transcription factors and nuclear receptors in HepaRG cells.

  
  

  
  

• Supplemental Figure 3 -

  Supplemental Figure S3. Cytokine concentration-response curves for regulation of PXR and CAR as compared to CYP3A4.
  
  

• Supplemental Table 1 -

  Supplemental Table S1. Primer sequences.
  

• Supplemental Table 2 -

  Supplemental Table S2. MRM parameters and retention time for the quantified analytes by the LCMS/MS method.
  
  
  

• Supplemental Table 3 -

  Supplemental Table S3. MRM parameters and retention time for the quantified analytes by the LCMS/MS method.