Data Supplement

• Supplemental Figures -

  Supplemental Figure S1. a) The expression levels (TPM) of NR1I3 transcripts in the liver (data are from GTEx). B) The alternative splicing of NR1I3 caused by different 3’ splice sites of exons 7, 8, and 9 is shown.

  Supplemental Figure S2. NR1I3 splice isoforms identified by fragment analysis.

  Supplemental Figure S3. The percentage of total CYP expression variability that is explained by gene-level or isoform-level expression of NR1I3 in AA (a) and EA (b) liver samples.
  

• Supplemental Tables -

  Supplemental Table S1. Demographics of liver donors.

  Supplemental Table S2. Sequence of primers.

  Supplemental Table S3. Information of NR1I3 splice isoforms.

  Supplemental Table S4. Splice isoforms detected in E1-E5 locus.

  Supplemental Table S5. Basic statistics of the composition of transcripts in E1-E5 and E6-E9 loci in liver samples.

  Supplemental Table S6. The differences in the composition of NR1I3 alternative splice isoforms in liver samples from AA and EA donors.

  Supplemental Table S7. Comparison of the associations between the CYPs and NR1I3 at the gene- or isoform-levels in liver samples from AA donors.