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Drug Metabolism & Disposition

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Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

Articles

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    Ontogeny of Scaling Factors for Pediatric PBPK Modeling and Simulation: Cytosolic Protein Per Gram of Liver
    Stephani L. Stancil, Robin E. Pearce, Vincent S. Staggs and J. Steven Leeder
    Drug Metabolism and Disposition September 21, 2023, DMD-AR-2023-001417; DOI: https://doi.org/10.1124/dmd.123.001417
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    Quantitative analysis of mRNA and protein expression levels of aldo-keto reductase and short-chain dehydrogenase/reductase isoforms in the human intestine
    Keiya Hirosawa, Hijiri Fujioka, Gaku Morinaga, Tatsuki Fukami, Naoki Ishiguro, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi and Miki Nakajima
    Drug Metabolism and Disposition September 18, 2023, DMD-AR-2023-001402; DOI: https://doi.org/10.1124/dmd.123.001402
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    Characterization of Pharmacokinetics, Biotransformation and Elimination of Pomotrelvir Orally Administered in Healthy Male Adults Using Two [14C]-labeled Microtracers with Separate Labeling Positions
    Ziping Yang, Shekman L. Wong, David Cha, David Wilfret, David Turnquist, Andrew Plummer, Eric van Ingen and Brian P Kearney
    Drug Metabolism and Disposition September 8, 2023, DMD-AR-2023-001439; DOI: https://doi.org/10.1124/dmd.123.001439
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    Bempedoic acid unveils therapeutic potential in non-alcoholic fatty liver disease: suppression of the hepatic PXR-SLC13A5/ACLY signaling axis
    Qiushuang Sun, Yating Guo, Wenjun Hu, Mengdi Zhang, Shijiao Wang, Yuanyuan Lei, Haitao Meng, Ning Li, Pengfei Xu, Zhiyu Li, Haishu Lin, Fang Huang and Zhixia Qiu
    Drug Metabolism and Disposition September 8, 2023, DMD-AR-2023-001449; DOI: https://doi.org/10.1124/dmd.123.001449
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    Pharmacokinetics and Absorption, Distribution, Metabolism and Excretion of RGLS4326 in Mouse and Monkey, an anti-miR-17 Oligonucleotide for the Treatment of Polycystic Kidney Disease
    Amin Kamel, Tate Owen, Izaiah Cole, Tania Valencia and Edmund C Lee
    Drug Metabolism and Disposition August 29, 2023, DMD-AR-2023-001446; DOI: https://doi.org/10.1124/dmd.123.001446
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    Prediction of Drug-Drug Interactions with Ensartinib as a Time Dependent CYP3A Inhibitor Using Physiologically Based Pharmacokinetic Model
    Xiaowen Wang, Yiqun Yu, Hongrui Liu, Fengjiao Bu, Chunying Shen, Qingfeng He, Xiao Zhu, Pin Jiang, Bing Han and Xiaoqiang Xiang
    Drug Metabolism and Disposition August 29, 2023, DMD-AR-2023-001373; DOI: https://doi.org/10.1124/dmd.123.001373
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    Heterodimerization of human UDP-glucuronosyltransferase (UGT) 1A9 and UGT2B7 alters their glucuronidation activities
    Jia Xue, Jiayi Yin, Jing Nie, Huidi Jiang, Haitao Zhang and Su Zeng
    Drug Metabolism and Disposition August 29, 2023, DMD-AR-2023-001369; DOI: https://doi.org/10.1124/dmd.123.001369
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    Potentiation of the Uricosuric Effect of Dotinurad by Trans-Inhibition of the Uric Acid Reabsorptive Transporter URAT1
    Kazuki Fujita, Qiunan Zhu, Hiroshi Arakawa, Yoshiyuki Shirasaka and Ikumi Tamai
    Drug Metabolism and Disposition August 29, 2023, DMD-AR-2023-001412; DOI: https://doi.org/10.1124/dmd.123.001412
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    Exploring the boundaries for in vitro-in vivo extrapolation: Use of isolated hepatocytes in co-culture and impact of albumin binding properties in the prediction of clearance of various drug types
    Laura Francis, Kayode Ogungbenro, Tom De Bruyn, J Brian Houston and David Hallifax
    Drug Metabolism and Disposition August 14, 2023, DMD-AR-2023-001309; DOI: https://doi.org/10.1124/dmd.123.001309
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    Goldenseal-mediated inhibition of intestinal uptake transporters decreases metformin systemic exposure in mice
    Victoria O Oyanna, Kenisha Y Garcia-Torres, Baron J Bechtold, Katherine D Lynch, M Ridge Call, Miklós Horváth, Preston K Manwill, Tyler N Graf, Nadja B. Cech, Nicholas H. Oberlies, Mary F. Paine and John D. Clarke
    Drug Metabolism and Disposition August 10, 2023, DMD-AR-2023-001360; DOI: https://doi.org/10.1124/dmd.123.001360
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    The Utility of Mixed-Effects Models in the Evaluation of Complex Genomic Traits In Vitro
    Nathan Alade, Abhinav Nath, Nina Isoherranen and Kenneth E. Thummel
    Drug Metabolism and Disposition August 10, 2023, DMD-AR-2023-001260; DOI: https://doi.org/10.1124/dmd.123.001260
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    CYP2D6 activity is correlated with changes in plasma concentrations of taurocholic acid during pregnancy and postpartum in CYP2D6 extensive metabolizers
    Lindsay C Czuba, Karan Malhotra, Luke Enthoven, Emily E Fay, Sue L Moreni, Jennie Mao, Yuanyuan Shi, Weize Huang, Rheem A Totah, Nina Isoherranen and Mary F. Hebert
    Drug Metabolism and Disposition August 7, 2023, DMD-AR-2023-001358; DOI: https://doi.org/10.1124/dmd.123.001358
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    Human carboxylesterase 1A plays a predominant role in hydrolysis of the anti-dyslipidemia agent fenofibrate in humans
    Hong-Xin Li, Meng-Ru Sun, Ya Zhang, Li-Lin Song, Feng Zhang, Yun-Qing Song, Xu-Dong Hou and Guang-Bo Ge
    Drug Metabolism and Disposition August 7, 2023, DMD-AR-2023-001365; DOI: https://doi.org/10.1124/dmd.123.001365
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    A comprehensive evaluation of the effects of RNA-editing proteins ADAR and ADARB1 on the expression of the drug-metabolizing enzymes in HepaRG cells
    Joseph M Collins and Danxin Wang
    Drug Metabolism and Disposition August 2, 2023, DMD-AR-2023-001396; DOI: https://doi.org/10.1124/dmd.123.001396

Commentaries

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    Commentary Kirchhoff's Laws and Hepatic Clearance, Well-Stirred Model - Is There Common Ground?
    Malcolm Rowland, Michael Weiss and K. Sandy Pang
    Drug Metabolism and Disposition August 10, 2023, DMD-COM-2023-001300; DOI: https://doi.org/10.1124/dmd.123.001300

Minireview

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    Potential and Challenges in Application of Physiologically Based Pharmacokinetic Modeling in Predicting Diarrheal Disease Impact on Oral Drug Pharmacokinetics
    Cindy X. Zhang and Samuel L.M. Arnold
    Drug Metabolism and Disposition September 15, 2023, DMD-MR-2022-000964; DOI: https://doi.org/10.1124/dmd.122.000964
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    Metabolism and excretion of therapeutic peptides: current industry practices, perspectives, and recommendations
    Minxia Michelle He, Sean Xiaochun Zhu, Joe R Cannon, Jesper Kammersgaard Christensen, Ruchia Duggal, Mithat Gunduz, Constanze Hilgendorf, Adam Hughes, Ivy Kekessie, Maximilian Kullmann, Dennis Leung, Carsten Terjung, Kai Wang and Frank Wesche
    Drug Metabolism and Disposition August 17, 2023, DMD-AR-2023-001437; DOI: https://doi.org/10.1124/dmd.123.001437
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    Central mechanisms of acetaminophen hepatotoxicity: mitochondrial dysfunction by protein adducts and oxidant stress
    Hartmut Jaeschke and Anup Ramachandran
    Drug Metabolism and Disposition August 11, 2023, DMD-MR-2023-001279; DOI: https://doi.org/10.1124/dmd.123.001279

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