Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

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Impact of Genetic Polymorphisms and Drug-Drug Interactions Mediated by Carboxylesterase1 on Remimazolam Deactivation
Zhuo Wang, Zachary McCalla, Li Lin, Dominic Tornichio, Yaw Agyemang, John A. Bastulli, Xiaochun Susan Zhang, Hao-Jie Zhu and Xinwen Wang

Drug Metabolism and Disposition November 5, 2024, DMD-AR-2024-001916; DOI: https://doi.org/10.1124/dmd.124.001916
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Characterization of human alcohol dehydrogenase 4 and aldehyde dehydrogenase 2 as enzymes involved in the formation of 5-carboxylpirfenidone, a major metabolite of pirfenidone
Rei Sato, Tatsuki Fukami, Kazuya Shimomura, Yongjie Zhang, Masataka Nakano and Miki Nakajima

Drug Metabolism and Disposition October 29, 2024, DMD-AR-2024-001917; DOI: https://doi.org/10.1124/dmd.124.001917
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Heterotropic Allosteric Modulation of CYP3A4 In Vitro by Progesterone: Evidence for Improvement in Prediction of Time Dependent Inhibition for Macrolides
Luc R.A. Rougee, Pooja V. Hegde, Kaitlin Shin, Trent L. Abraham, Alec Bell and Stephen D. Hall

Drug Metabolism and Disposition October 29, 2024, DMD-AR-2024-001820; DOI: https://doi.org/10.1124/dmd.124.001820
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Uncovering the Impact of COVID-19 Mediated Bidirectional Dysregulation of CYP3A4 on Systemic and Pulmonary Drug Concentrations Using Physiologically Based Pharmacokinetic Modeling
Chukwunonso K. Nwabufo

Drug Metabolism and Disposition October 29, 2024, DMD-AR-2024-001893; DOI: https://doi.org/10.1124/dmd.124.001893
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Pharmacokinetics and ADME Profiling of Tanimilast Following an Intravenous ¹⁴C-Microtracer co-administered with an Inhaled Dose in Healthy Male Individuals
Michele Bassi, Veronica Puviani, Debora Santoro, Sonia Biondaro, Aida Emirova and Mirco Govoni

Drug Metabolism and Disposition October 29, 2024, DMD-AR-2024-001895; DOI: https://doi.org/10.1124/dmd.124.001895
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Isoform-level expression of the constitutive androstane receptor (CAR or NR1I3) transcription factor better predicts the mRNA expression of the cytochrome P450s in human liver samples
Joseph M Collins and Danxin Wang

Drug Metabolism and Disposition October 21, 2024, DMD-AR-2024-001923; DOI: https://doi.org/10.1124/dmd.124.001923
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Absolute Membrane Protein Abundance of P-gp, BCRP and MRPs in Term Human Placenta Tissue and Commonly Used Cell Systems: Application in PBPK Modeling of Placental Drug Disposition
Zubida M. Al-Majdoub, Jolien J.M. Freriksen, Angela Colbers, Jeroen van den Heuvel, Jan Koenderink, Khaled Abduljalil, Brahim Achour, Jill Barber, Rick Greupink and Amin Rostami-Hodjegan

Drug Metabolism and Disposition October 21, 2024, DMD-AR-2024-001824; DOI: https://doi.org/10.1124/dmd.124.001824
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Environmentally Persistent Free Radicals stimulate CYP2E1-mediated generation of reactive oxygen species at the expense of substrate metabolism
George F Cawley, J. Patrick Connick, Marilyn K Eyer and Wayne L. Backes

Drug Metabolism and Disposition October 21, 2024, DMD-AR-2024-001939; DOI: https://doi.org/10.1124/dmd.124.001939
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Intestine vs. Liver？Uncovering the Hidden major Metabolic organs of Silybin in Rats
Yuanbo Sun, Like Xie, Jing Zhang, Runing Liu, Hanbing Li, Yanquan Yang, Yapeng Wu, Ying Peng, Guangji Wang, Natalie Medlicott and Jianguo Sun

Drug Metabolism and Disposition October 17, 2024, DMD-AR-2024-001817; DOI: https://doi.org/10.1124/dmd.124.001817
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Utilization of a Human Liver Tissue Chip for Drug-Metabolizing Enzyme Induction Studies of Perpetrator and Victim Drugs
Shivam Ohri, Paarth Parekh, Lauren Nichols, Shiny Amala Priya Rajan and Murat Cirit

Drug Metabolism and Disposition October 7, 2024, DMD-AR-2023-001497; DOI: https://doi.org/10.1124/dmd.124.001497
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Human Enteroid Monolayers: A Novel, Functionally-Stable Model for Investigating Oral Drug Disposition
Christopher Arian, Eimear O'Mahony, James W. MacDonald, Theo K Bammler, Mark Donowitz, Edward J. Kelly and Kenneth E. Thummel

Drug Metabolism and Disposition August 9, 2024, DMD-AR-2023-001551; DOI: https://doi.org/10.1124/dmd.124.001551
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Comparative Analysis of the Physiological and Transport Functions of Various Sources of Renal Proximal Tubule Cells Under Static and Fluidic Conditions in PhysioMimix{trade mark, serif} T12 Platform
Courtney Sakolish, Haley L. Moyer, Han-Hsuan D Tsai, Lucie C Ford, Allison N Dickey, Piyush Bajaj, Remi Villenave, Philip Hewitt, Stephen S. Ferguson, Jason Stanko and Ivan Rusyn

Drug Metabolism and Disposition April 16, 2024, DMD-AR-2023-001488; DOI: https://doi.org/10.1124/dmd.124.001488

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Efflux transporters in drug disposition during pregnancy
Xin Chen, Chunying Gao, Lyrialle W Han, Sibylle Heidelberger, Michael Z Liao, Naveen K Neradugomma, Zhanglin Ni, Diana L Shuster, Honggang Wang, Yi Zhang and Lin Zhou

Drug Metabolism and Disposition May 29, 2024, DMD-MR-2023-001385; DOI: https://doi.org/10.1124/dmd.123.001385
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The ADME characteristics of siRNA therapeutics and the opportunity to predict disposition in pregnant women.
Ogochukwu Amaeze, Nina Isoherranen and Sara Shum

Drug Metabolism and Disposition May 29, 2024, DMD-MR-2023-001383; DOI: https://doi.org/10.1124/dmd.123.001383
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Physiologically Based Pharmacokinetic (PBPK) Modeling of small molecules: How Much Progress Have We Made?
Nina Isoherranen

Drug Metabolism and Disposition February 7, 2024, DMD-MR-2022-000960; DOI: https://doi.org/10.1124/dmd.123.000960
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Utility of PBPK Modeling in Predicting and Characterizing Clinical Drug Interactions
Robert S. Foti

Drug Metabolism and Disposition January 30, 2024, DMD-MR-2023-001384; DOI: https://doi.org/10.1124/dmd.123.001384
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Real-world application of PBPK in drug discovery
Laura G A Santos, Swati Jaiswal, Kuan-Fu Chen, Hannah M. Jones and Ian E. Templeton

Drug Metabolism and Disposition December 12, 2023, DMD-MR-2022-001036; DOI: https://doi.org/10.1124/dmd.122.001036
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Potential and Challenges in Application of Physiologically Based Pharmacokinetic Modeling in Predicting Diarrheal Disease Impact on Oral Drug Pharmacokinetics
Cindy X. Zhang and Samuel L.M. Arnold

Drug Metabolism and Disposition September 15, 2023, DMD-MR-2022-000964; DOI: https://doi.org/10.1124/dmd.122.000964

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