Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

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Investigating the Utility of Humanized PXR-CAR-CYP3A4/7 Mouse Model to Assess CYP3A-Mediated Induction
Justin Q. Ly, Susan Wong, Liling Liu, Ruina Li, Kirsten Messick and Jae H. Chang

Drug Metabolism and Disposition April 16, 2021, DMD-AR-2021-000439; DOI: https://doi.org/10.1124/dmd.121.000439
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IVIVE of Transporter-Mediated Renal Clearance: Relative Expression Factor (REF) vs Relative Activity Factor (RAF) Approach
Aditya R. Kumar, Bhagwat Prasad, Deepak Kumar Bhatt, Sumathy Mathialagan, Manthena V. S. Varma and Jashvant D. Unadkat

Drug Metabolism and Disposition April 6, 2021, DMD-AR-2021-000367; DOI: https://doi.org/10.1124/dmd.121.000367
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Pharmacokinetic and biochemical profiling of Sodium Dichloroacetate in pregnant ewes and fetuses
Serene Joseph, Abhisheak Sharma, Lloyd P. Horne, Charles E. Wood, Taimour Langaee, Margaret O. James, Peter W. Stacpoole and Maureen Keller-Wood

Drug Metabolism and Disposition April 2, 2021, DMD-AR-2020-000330; DOI: https://doi.org/10.1124/dmd.120.000330
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Cytochrome P450 3A Time-Dependent Inhibition Assays are Too Sensitive for Identification of Drugs Causing Clinically Significant Drug-Drug Interactions: A Comparison of Human Liver Microsomes and Hepatocytes and Definition of Boundaries for Inactivation Rate Constants
Heather Eng, Elaine Tseng, Matthew A. Cerny, Theunis C. Goosen and R. Scott Obach

Drug Metabolism and Disposition April 2, 2021, DMD-AR-2021-000356; DOI: https://doi.org/10.1124/dmd.121.000356
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Reversible and irreversible inhibition of cytochrome P450 enzymes by methylophiopogonanone A
Dong-Zhu Tu, Xu Mao, Feng Zhang, Rong-Jing He, Jing-Jing Wu, Yue Wu, Xiao-Hua Zhao, Jiang Zheng and Guang-Bo Ge

Drug Metabolism and Disposition April 2, 2021, DMD-AR-2020-000325; DOI: https://doi.org/10.1124/dmd.120.000325
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Metabolism and Mass Balance of the Novel Nonsteroidal Androgen Receptor Inhibitor Darolutamide in Humans
Päivi Taavitsainen, Olaf Prien, Marja Kähkönen, Michael Niehues, Timo Korjamo, Karsten Denner, Pirjo Nykänen, Annamari Vuorela, Natalia A. Jungmann, Clemens-Jeremias von Bühler, Mikko Koskinen, Christian Zurth and Hille Gieschen

Drug Metabolism and Disposition March 30, 2021, DMD-AR-2020-000309; DOI: https://doi.org/10.1124/dmd.120.000309
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Dual action of acidic microenvironment on the enrichment of the active metabolite of disulfiram in tumor tissues
Chongzhuang Tang, Xiaoyan Pang, Zitao Guo, Runcong Guo, Lu Liu and Xiaoyan Chen

Drug Metabolism and Disposition March 24, 2021, DMD-AR-2020-000317; DOI: https://doi.org/10.1124/dmd.120.000317

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