Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

Articles

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Pharmacokinetics, Mass Balance, and Metabolism of the Novel URAT1 Inhibitor [¹⁴C]HR011303 in Humans: Metabolism is Mediated Predominantly by UDP-glucuronosyltransferase
Yuandong Zheng, Hua Zhang, Mengling Liu, Guangze Li, Sheng Ma, Zhe Zhang, Hongda Lin, Yan Zhan, Zhendong Chen, Dafang Zhong, Liyan Miao and Xingxing Diao

Drug Metabolism and Disposition December 3, 2021, DMD-AR-2021-000581; DOI: https://doi.org/10.1124/dmd.121.000581
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Mechanistic study on the species differences in excretion pathway of HR011303 in human and rats
Zitao Guo, Mengling Liu, Jian Meng, Yaru Xue, Qi Huang, Yuandong Zheng, Yali Wu, Zhendong Chen, Jinghua Yu, Dafang Zhong, Guangze Li, Xiaoyan Chen and Xingxing Diao

Drug Metabolism and Disposition December 3, 2021, DMD-AR-2021-000582; DOI: https://doi.org/10.1124/dmd.121.000582
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Regulation of transporters by perfluorinated carboxylic acids in HepaRG cells
Joe Jongpyo Lim, Youjun Suh, Elaine M Faustman and Julia Yue Cui

Drug Metabolism and Disposition December 2, 2021, DMD-AR-2021-000477; DOI: https://doi.org/10.1124/dmd.121.000477
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Broad application of CYP3A4 LC-MS protein quantification in hepatocyte cytochrome P450 induction assays identifies nonuniformity in mRNA and protein induction responses
John P. Savaryn, Jun Sun, Junli Ma, Gary J. Jenkins and David M. Stresser

Drug Metabolism and Disposition December 2, 2021, DMD-AR-2021-000638; DOI: https://doi.org/10.1124/dmd.121.000638
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Characterization of clinical ADME and pharmacokinetics of velsecorat using an intravenous microtracer combined with an inhaled dose in healthy subjects
Ann A Holmberg, Lars Weidolf, Sofia Necander, Peter Bold, Sharan Sidhu, Marta Pelay-Gimeno, Rianne A.F. de Ligt, Elwin R Verheij, Alexandra Jauhiainen, Ioannis Psallidas, Ulrika Wählby Hamrén and Susanne Prothon

Drug Metabolism and Disposition December 1, 2021, DMD-AR-2021-000632; DOI: https://doi.org/10.1124/dmd.121.000632
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Exposure to High-Altitude Environment is Associated with Drug Transporters Change: miR-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
Yabin Duan, Xue Bai, Jianxin Yang, Yang Zhou, Wenqi Gu, Guiqin Liu, Qian Wang, Junbo Zhu, Linli La and Xiangyang Li

Drug Metabolism and Disposition November 29, 2021, DMD-AR-2021-000681; DOI: https://doi.org/10.1124/dmd.121.000681
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Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19 and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model
Diane Ramsden, Elke S. Perloff, Andrea Whitcher-Johnstone, Thuy Ho, Reena Patel, Kirk D. Kozminski, Cody L. Fullenwider and J George Zhang

Drug Metabolism and Disposition November 17, 2021, DMD-AR-2021-000718; DOI: https://doi.org/10.1124/dmd.121.000718
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Metabolism of a selective serotonin and norepinephrine reuptake inhibitor duloxetine in liver microsomes and mice
Xuan Qin, John M. Hakenjos, Kevin R. MacKenzie, Mercedes Barzi, Hemantkumar Chavan, Pranavanand Nyshadham, Jin Wang, Sung Yun Jung, Joie Z. Guner, Si Chen, Lei Guo, Partha Krishnamurthy, Karl-Dimiter Bissig, Stephen Palmer, Martin M. Matzuk and Feng Li

Drug Metabolism and Disposition November 16, 2021, DMD-AR-2021-000633; DOI: https://doi.org/10.1124/dmd.121.000633
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The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
Erin C Berthold, Shyam H Kamble, Kanumuri S Raju, Michelle A Kuntz, Alexandria S Senetra, Marco Mottinelli, Francisco León, Luis F Restrepo, Avi Patel, Nicholas P Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy

Drug Metabolism and Disposition November 10, 2021, DMD-AR-2021-000640; DOI: https://doi.org/10.1124/dmd.121.000640
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Permeabilized cryopreserved human hepatocytes as an exogenous metabolic system in a novelmetabolism-dependent cytotoxicity assay (MDCA) for the evaluation of metabolic activation anddetoxification of drugs associated with drug induced liver injuries: Results with acetaminophen,amiodarone, cyclophosphamide, ketoconazole, nefazodone, and troglitazone
Hong Wei and Albert P. Li

Drug Metabolism and Disposition November 8, 2021, DMD-AR-2021-000645; DOI: https://doi.org/10.1124/dmd.121.000645
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Evaluation of ADMET Predictor^TM in early discovery DMPK project work
Anna-Karin Sohlenius-Sternbeck and Ylva Terelius

Drug Metabolism and Disposition November 8, 2021, DMD-AR-2021-000552; DOI: https://doi.org/10.1124/dmd.121.000552
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The impact of age and genetics on naltrexone biotransformation
Stephani L. Stancil, Whitney Nolte, Robin E. Pearce, Vincent S. Staggs and J. Steven Leeder

Drug Metabolism and Disposition November 2, 2021, DMD-AR-2021-000646; DOI: https://doi.org/10.1124/dmd.121.000646
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Transcriptional regulation of carboxylesterase 1 (CES1) in human liver: role of the nuclear receptor NR1H3 (LXRα) and its splice isoforms
Joseph M Collins, Rong Lu, Xinwen Wang, Hao-Jie Zhu and Danxin Wang

Drug Metabolism and Disposition October 25, 2021, DMD-AR-2021-000649; DOI: https://doi.org/10.1124/dmd.121.000649
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Intestinal UGT1A1 and protection against Irinotecan-induced toxicity in a novel UGT1A1 tissue-specific humanized mouse model.
Elvira Mennillo, Xiaojing Yang, Andre A Weber, Yoshihiro Maruo, Melanie Verreault, Olivier Barbier, Shujuan Chen and Robert H. Tukey

Drug Metabolism and Disposition October 25, 2021, DMD-AR-2021-000644; DOI: https://doi.org/10.1124/dmd.121.000644
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Ontogeny of Scaling Factors for Pediatric PBPK Modeling and Simulation: Microsomal Protein Per Gram of Liver
J. Steven Leeder, Jean C. Dinh, Andrea Gaedigk, Vincent S. Staggs, Bhagwat Prasad and Robin E. Pearce

Drug Metabolism and Disposition October 22, 2021, DMD-AR-2021-000623; DOI: https://doi.org/10.1124/dmd.121.000623
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Simultaneous evaluation of membrane permeability and UDP-glucuronosyltransferase-mediated metabolism of food-derived compounds using human induced pluripotent stem cell-derived small intestinal epithelial cells
Takashi Kitaguchi, Taisei Mizota, Mina Ito, Katsutoshi Ohno, Kazuhiro Kobayashi, Isamu Ogawa, Shimeng Qiu, Takahiro Iwao, Nobumitsu Hanioka, Mitsuru Tanaka and Tamihide Matsunaga

Drug Metabolism and Disposition October 20, 2021, DMD-AR-2021-000605; DOI: https://doi.org/10.1124/dmd.121.000605
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New pharmacokinetic parameters of imaging substrates quantified from rat liver compartments
Catherine M Pastor and Kim LR Brouwer

Drug Metabolism and Disposition October 20, 2021, DMD-AR-2021-000546; DOI: https://doi.org/10.1124/dmd.121.000546
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Simulating the Selection of Resistant Cells with Bystander Killing and Antibody Coadministration in Heterogeneous HER2 Positive Tumors
Bruna Menezes, Jennifer J. Linderman and Greg M. Thurber

Drug Metabolism and Disposition October 14, 2021, DMD-AR-2021-000503; DOI: https://doi.org/10.1124/dmd.121.000503
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Cytochrome P450 Binding and Bioactivation of Tumor-targeted Duocarmycin Agents
Aaron G. Bart, Goreti Morais, Venu R. Vangala, Paul M. Loadman, Klaus Pors and Emily E. Scott

Drug Metabolism and Disposition October 4, 2021, DMD-AR-2021-000642; DOI: https://doi.org/10.1124/dmd.121.000642
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Augmented clearance of nivolumab is associated with renal functions in chronic renal disease model rats
Kazuaki Taguchi, Yukitaka Hayashi, Mayu Ohuchi, Hotaka Yamada, Shigehiro Yagishita, Yuki Enoki, Kazuaki Matsumoto and Akinobu Hamada

Drug Metabolism and Disposition August 4, 2021, DMD-AR-2021-000520; DOI: https://doi.org/10.1124/dmd.121.000520
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Alterations of cytochrome P450-mediated drug metabolism during liver repair and regeneration after acetaminophen-induced liver injury in mice
Yifan Bao, Mi Phan, Junjie Zhu, Xiaochao Ma, Jose E. Manautou and Xiao-bo Zhong

Drug Metabolism and Disposition August 4, 2021, DMD-AR-2021-000459; DOI: https://doi.org/10.1124/dmd.121.000459

Commentaries

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In defense of current concepts and applications of clearance in drug development and therapeutics
Malcolm Rowland, Michael S. Roberts and K. Sandy Pang

Drug Metabolism and Disposition November 5, 2021, DMD-AR-2021-000637; DOI: https://doi.org/10.1124/dmd.121.000637

Minireview

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PXR and the gut-liver axis: a recent update
Moumita Dutta, Joe Jongpyo Lim and Julia Yue Cui

Drug Metabolism and Disposition December 3, 2021, DMD-MR-2021-000415; DOI: https://doi.org/10.1124/dmd.121.000415
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Environmental Chemical Contribution to the Modulation of Bile Acid Homeostasis and Farnesoid X Receptor Signaling
Rulaiha Elizabeth Taylor, Anisha Bhattacharya and Grace L. Guo

Drug Metabolism and Disposition November 10, 2021, DMD-MR-2021-000388; DOI: https://doi.org/10.1124/dmd.121.000388
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Overview of Current Herb-Drug Interaction Databases
Yufeng Zhang, Chung Man Ip, Yuen Sze Lai and Zhong Zuo

Drug Metabolism and Disposition October 25, 2021, DMD-MR-2021-000420; DOI: https://doi.org/10.1124/dmd.121.000420
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MOLECULAR REGULATION OF BILE ACID HOMEOSTASIS
Supratim Choudhuri and Curtis D. Klaassen

Drug Metabolism and Disposition October 22, 2021, DMD-MR-2021-000643; DOI: https://doi.org/10.1124/dmd.121.000643
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Addressing today's ADME challenges in the translation of in vitro absorption, distribution, metabolism and excretion characteristics to human: A case study of the SMN2 mRNA splicing modifier risdiplam
Stephen Fowler, Andreas Brink, Yumi Cleary, Andreas Guenther, Katja Heinig, Christophe Husser, Heidemarie Kletzl, Nicole A. Kratochwil, Lutz Mueller, Mark Savage, Cordula Stillhart, Dietrich W. Tuerck, Mohammed Ullah, Kenichi Umehara and Agnès Poirier

Drug Metabolism and Disposition October 7, 2021, DMD-MR-2021-000563; DOI: https://doi.org/10.1124/dmd.121.000563
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Pharmacokinetic Drug-Drug Interactions with Drugs Approved by the U.S. Food and Drug Administration in 2020: Mechanistic Understanding and Clinical Recommendations
Jingjing Yu, Yan Wang and Isabelle Ragueneau-Majlessi

Drug Metabolism and Disposition October 7, 2021, DMD-MR-2021-000401; DOI: https://doi.org/10.1124/dmd.121.000401
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Exogenous Drug Disposition as a Diagnostic Biomarker Strategy for Non-Alcoholic Steatohepatitis
Solène MARIE, David K.K. TRIPP and Nathan J. CHERRINGTON

Drug Metabolism and Disposition September 16, 2021, DMD-MR-2021-000413; DOI: https://doi.org/10.1124/dmd.121.000413
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Feature, Function, and Information of Drug Transporter Related Databases
Jiayi Yin, Fengcheng Li, Zhaorong Li, Lushan Yu, Feng Zhu and Su Zeng

Drug Metabolism and Disposition August 23, 2021, DMD-MR-2021-000419; DOI: https://doi.org/10.1124/dmd.121.000419
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The Nonclinical Disposition and PK/PD Properties of GalNAc-conjugated siRNA Are Highly Predictable and Build Confidence in Translation to Man
Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher R. Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Christopher Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu

Drug Metabolism and Disposition June 29, 2021, DMD-MR-2021-000428; DOI: https://doi.org/10.1124/dmd.121.000428

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