Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

Articles

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Primary human hepatocyte spheroids as an in vitro tool for investigating drug compounds with low clearance
Julia Riede, Birgit M. Wollmann, Espen Molden and Magnus Ingelman-Sundberg

Drug Metabolism and Disposition June 1, 2021, DMD-AR-2020-000340; DOI: https://doi.org/10.1124/dmd.120.000340
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Times New Roman',serif;">Characterization of a novel CYP1A2 knockout rat model constructed by CRISPR/Cas9
Dongyi Sun, Jian Lu, Yuanjin Zhang, Jie Liu, Zongjun Liu, Bingyi Yao, Yuanqing Guo and Xin Wang

Drug Metabolism and Disposition June 1, 2021, DMD-AR-2021-000403; DOI: https://doi.org/10.1124/dmd.121.000403
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Quantitative investigation of irinotecan metabolism, transport and gut microbiome activation
Md Masud Parvez, Abdul Basit, Parth B. Jariwala, Zsuzsanna Gáborik, Emese Kis, Scott Heyward, Matthew R. Redinbo and Bhagwat Prasad

Drug Metabolism and Disposition June 1, 2021, DMD-AR-2021-000476; DOI: https://doi.org/10.1124/dmd.121.000476
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BCRP/ABCG2 Transporter Regulates Accumulation of Cadmium in Kidney Cells: Role of the Q141K Variant in Modulating Nephrotoxicity
Xia Wen, Danielle Kozlosky, Ranran Zhang, Cathleen Doherty, Brian Buckley, Emily Barrett and Lauren M. Aleksunes

Drug Metabolism and Disposition June 1, 2021, DMD-AR-2021-000446; DOI: https://doi.org/10.1124/dmd.121.000446
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Comparative hepatic and intestinal metabolism and pharmacodynamics of statins
Anne M. Filppula, Päivi Hirvensalo, Heli Parviainen, Vilma E. Ivaska, K. Ivar Lönnberg, Feng Deng, Jenni Viinamäki, Mika Kurkela, Mikko Neuvonen and Mikko Niemi

Drug Metabolism and Disposition May 27, 2021, DMD-AR-2021-000406; DOI: https://doi.org/10.1124/dmd.121.000406
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Proteomic Quantification of Changes in Abundance of Drug-Metabolizing Enzymes and Drug Transporters in Human Liver Cirrhosis: Different Methods, Similar Outcomes
Eman El-Khateeb, Zubida M. Al-Majdoub, Amin Rostami-Hodjegan, Jill Barber and Brahim Achour

Drug Metabolism and Disposition May 27, 2021, DMD-AR-2021-000484; DOI: https://doi.org/10.1124/dmd.121.000484
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3,3'-Diindolylmethane (BioResponse DIM^®) Exhibits Significant Metabolism Following Oral Dosing in Humans
Monica L. Vermillion Maier, Lisbeth K. Siddens, Sandra L. Uesugi, Jaewoo Choi, Scott W. Leonard, Jamie M. Pennington, Susan C. Tilton, Jordan N. Smith, Emily Ho, H.H. Sherry Chow, Bach D. Nguyen, Siva K. Kolluri and David E. Williams

Drug Metabolism and Disposition May 25, 2021, DMD-AR-2020-000346; DOI: https://doi.org/10.1124/dmd.120.000346
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Deconvolution of CYP Induction Mechanisms in HepaRG Nuclear Hormone Receptor Knockout Cells
Lena C. Preiss, Ruoqi Liu, Philip Hewitt, David Thompson, Katrin Georgi, Lassina Badolo, Volker M. Lauschke and Carl Petersson

Drug Metabolism and Disposition May 25, 2021, DMD-AR-2020-000333; DOI: https://doi.org/10.1124/dmd.120.000333
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Assessment of the Potential for Veverimer Drug-Drug Interactions
Dawn Parsell, Jun Shao, Robert Guttendorf, Vandana Mathur, Elizabeth Li, Yick Sen Wu, Li Tsao, Scott Tabakman, Yuri Stasiv, Angela Lee, Kalpesh Biyani and Gerrit Klaerner

Drug Metabolism and Disposition May 24, 2021, DMD-AR-2021-000366; DOI: https://doi.org/10.1124/dmd.121.000366
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Passive influx and ion trapping are more relevant to the cellular accumulation of highly permeable low molecular weight acidic drugs than is Organic Anion Transporter 2 (OAT2)
Dallas Bednarczyk

Drug Metabolism and Disposition May 24, 2021, DMD-AR-2021-000425; DOI: https://doi.org/10.1124/dmd.121.000425
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Investigation into MAO B-mediated formation of CC112273, a major circulating metabolite of ozanimod, in humans and preclinical species: Stereospecific oxidative deamination of (S)-enantiomer of indaneamine (RP101075) by MAO B
April Bai, Veerabahu .Shanmugasundaram, Julie V. Selkirk, Sekhar Surapaneni and Deepak Dalvie

Drug Metabolism and Disposition May 19, 2021, DMD-AR-2021-000447; DOI: https://doi.org/10.1124/dmd.121.000447
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Negative Regulation of Human Hepatic Constitutive Androstane Receptor by Cholesterol Synthesis Inhibition: Role of Sterol Regulatory Element Binding Proteins
Liberta Cuko, Zofia Duniec-Dmuchowski, Elizabeth A. Rondini, Asmita Pant, John K. Fallon, Elizabeth M. Wilson, Nicholas J. Peraino, Judy A. Westrick, Philip C. Smith and Thomas A. Kocarek

Drug Metabolism and Disposition May 19, 2021, DMD-AR-2020-000341; DOI: https://doi.org/10.1124/dmd.120.000341
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Pharmacokinetics, disposition, and biotransformation of [¹⁴C]-omecamtiv mecarbil in healthy male subjects after a single intravenous or oral dose.
Ashit Trivedi, Jan Wahlstrom, Mia Mackowski, Sandeep Dutta and Edward Lee

Drug Metabolism and Disposition May 19, 2021, DMD-AR-2021-000444; DOI: https://doi.org/10.1124/dmd.121.000444
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Multiple Computational Approaches for Predicting Drug Interactions with Human Equilibrative Nucleoside Transporter 1
Siennah R. Miller, Thomas R. Lane, Kimberley M. Zorn, Sean Ekins, Stephen H. Wright and Nathan Cherrington

Drug Metabolism and Disposition May 12, 2021, DMD-AR-2021-000423; DOI: https://doi.org/10.1124/dmd.121.000423
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Hepatic Scaling Factors for In Vitro-In Vivo Extrapolation (IVIVE) of Metabolic Drug Clearance in Patients with Colorectal Cancer with Liver Metastasis
Areti-Maria Vasilogianni, Brahim Achour, Daniel Scotcher, Sheila Annie Peters, Zubida M. Al-Majdoub, Jill Barber and Amin Rostami-Hodjegan

Drug Metabolism and Disposition May 12, 2021, DMD-AR-2021-000359; DOI: https://doi.org/10.1124/dmd.121.000359
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A new intestinal model for analysis of drug absorption and interactions considering physiological translocation of contents
Satoshi Asano, Aoi Yoshitomo, Shizuka Hozuki, Hiromi Sato, Yasuhiro Kazuki and Akihiro Hisaka

Drug Metabolism and Disposition May 7, 2021, DMD-AR-2021-000361; DOI: https://doi.org/10.1124/dmd.121.000361
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Improving the Translation of Organic Anion Transporting Polypeptide Substrates using HEK293 Cell Data in the Presence and Absence of Human Plasma via PBPK Modeling
Christine M. Bowman, Buyun Chen, Jonathan Cheong, Liling Liu, Yuan Chen and Jialin Mao

Drug Metabolism and Disposition May 6, 2021, DMD-AR-2020-000315; DOI: https://doi.org/10.1124/dmd.120.000315
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Evaluation of the Absorption, Metabolism, and Excretion of a Single Oral 1 mg Dose of Tropifexor in Healthy Male Subjects and the Concentration Dependency of Tropifexor Metabolism
Lydia Wang-Lakshman, Zhuang Miao, Lai Wang, Helen Gu, Mark Kagan, Jessie Gu, Elizabeth McNamara, Markus Walles, Ralph Woessner, Gian Camenisch, Heidi J. Einolf and Jin Chen

Drug Metabolism and Disposition May 5, 2021, DMD-AR-2020-000349; DOI: https://doi.org/10.1124/dmd.120.000349
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Comparative proteomics analysis of the post-mitochondrial supernatant fraction of human lens-free whole eye and liver
Ankit Balhara, Abdul Basit, Upendra A. Argikar, Jennifer L. Dumouchel, Saranjit Singh and Bhagwat Prasad

Drug Metabolism and Disposition May 5, 2021, DMD-AR-2020-000297; DOI: https://doi.org/10.1124/dmd.120.000297
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Development and verification of a linked ᵪB;⁹-THC/11-OH-THC physiologically-based pharmacokinetic (PBPK) model in healthy, non-pregnant population and extrapolation to pregnant women
Gabriela I. Patilea-Vrana and Jashvant D. Unadkat

Drug Metabolism and Disposition May 5, 2021, DMD-AR-2020-000322; DOI: https://doi.org/10.1124/dmd.120.000322
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Nonclinical Pharmacokinetics and ADME of Givosiran, the First Approved GalNAc-conjugated RNAi Therapeutic
Jing Li, Ju Liu, Xuemei Zhang, Valerie Clausen, Chris Tran, Michael Arciprete, Qianfan Wang, Carrie Rocca, Li-Hua Guan, Guodong Zhang, Diana Najarian, Yuanxin Xu, Peter Smith, Jing-Tao Wu and Saeho Chong

Drug Metabolism and Disposition May 4, 2021, DMD-AR-2021-000381; DOI: https://doi.org/10.1124/dmd.121.000381
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Preliminary Flow Modeling by Hybrid Automata Alternating Continuous Reaction and Discrete Transit for Pharmacokinetics
Satoshi Koyama

Drug Metabolism and Disposition May 3, 2021, DMD-AR-2020-000227; DOI: https://doi.org/10.1124/dmd.120.000227
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Investigating the Utility of Humanized PXR-CAR-CYP3A4/7 Mouse Model to Assess CYP3A-Mediated Induction
Justin Q. Ly, Susan Wong, Liling Liu, Ruina Li, Kirsten Messick and Jae H. Chang

Drug Metabolism and Disposition April 16, 2021, DMD-AR-2021-000439; DOI: https://doi.org/10.1124/dmd.121.000439
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IVIVE of Transporter-Mediated Renal Clearance: Relative Expression Factor (REF) vs Relative Activity Factor (RAF) Approach
Aditya R. Kumar, Bhagwat Prasad, Deepak Kumar Bhatt, Sumathy Mathialagan, Manthena V. S. Varma and Jashvant D. Unadkat

Drug Metabolism and Disposition April 6, 2021, DMD-AR-2021-000367; DOI: https://doi.org/10.1124/dmd.121.000367
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Reversible and irreversible inhibition of cytochrome P450 enzymes by methylophiopogonanone A
Dong-Zhu Tu, Xu Mao, Feng Zhang, Rong-Jing He, Jing-Jing Wu, Yue Wu, Xiao-Hua Zhao, Jiang Zheng and Guang-Bo Ge

Drug Metabolism and Disposition April 2, 2021, DMD-AR-2020-000325; DOI: https://doi.org/10.1124/dmd.120.000325

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Metabolism and hepatotoxicity of pyrazinamide, an anti-tuberculosis drug
Zahir Hussain, Junjie Zhu and Xiaochao Ma

Drug Metabolism and Disposition June 1, 2021, DMD-MR-2021-000389; DOI: https://doi.org/10.1124/dmd.121.000389

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