Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

Articles

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Ontogeny of Scaling Factors for Pediatric PBPK Modeling and Simulation: Cytosolic Protein Per Gram of Liver
Stephani L. Stancil, Robin E. Pearce, Vincent S. Staggs and J. Steven Leeder

Drug Metabolism and Disposition September 21, 2023, DMD-AR-2023-001417; DOI: https://doi.org/10.1124/dmd.123.001417
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Quantitative analysis of mRNA and protein expression levels of aldo-keto reductase and short-chain dehydrogenase/reductase isoforms in the human intestine
Keiya Hirosawa, Hijiri Fujioka, Gaku Morinaga, Tatsuki Fukami, Naoki Ishiguro, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi and Miki Nakajima

Drug Metabolism and Disposition September 18, 2023, DMD-AR-2023-001402; DOI: https://doi.org/10.1124/dmd.123.001402
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Characterization of Pharmacokinetics, Biotransformation and Elimination of Pomotrelvir Orally Administered in Healthy Male Adults Using Two [¹⁴C]-labeled Microtracers with Separate Labeling Positions
Ziping Yang, Shekman L. Wong, David Cha, David Wilfret, David Turnquist, Andrew Plummer, Eric van Ingen and Brian P Kearney

Drug Metabolism and Disposition September 8, 2023, DMD-AR-2023-001439; DOI: https://doi.org/10.1124/dmd.123.001439
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Bempedoic acid unveils therapeutic potential in non-alcoholic fatty liver disease: suppression of the hepatic PXR-SLC13A5/ACLY signaling axis
Qiushuang Sun, Yating Guo, Wenjun Hu, Mengdi Zhang, Shijiao Wang, Yuanyuan Lei, Haitao Meng, Ning Li, Pengfei Xu, Zhiyu Li, Haishu Lin, Fang Huang and Zhixia Qiu

Drug Metabolism and Disposition September 8, 2023, DMD-AR-2023-001449; DOI: https://doi.org/10.1124/dmd.123.001449
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Pharmacokinetics and Absorption, Distribution, Metabolism and Excretion of RGLS4326 in Mouse and Monkey, an anti-miR-17 Oligonucleotide for the Treatment of Polycystic Kidney Disease
Amin Kamel, Tate Owen, Izaiah Cole, Tania Valencia and Edmund C Lee

Drug Metabolism and Disposition August 29, 2023, DMD-AR-2023-001446; DOI: https://doi.org/10.1124/dmd.123.001446
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Prediction of Drug-Drug Interactions with Ensartinib as a Time Dependent CYP3A Inhibitor Using Physiologically Based Pharmacokinetic Model
Xiaowen Wang, Yiqun Yu, Hongrui Liu, Fengjiao Bu, Chunying Shen, Qingfeng He, Xiao Zhu, Pin Jiang, Bing Han and Xiaoqiang Xiang

Drug Metabolism and Disposition August 29, 2023, DMD-AR-2023-001373; DOI: https://doi.org/10.1124/dmd.123.001373
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Heterodimerization of human UDP-glucuronosyltransferase (UGT) 1A9 and UGT2B7 alters their glucuronidation activities
Jia Xue, Jiayi Yin, Jing Nie, Huidi Jiang, Haitao Zhang and Su Zeng

Drug Metabolism and Disposition August 29, 2023, DMD-AR-2023-001369; DOI: https://doi.org/10.1124/dmd.123.001369
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Potentiation of the Uricosuric Effect of Dotinurad by Trans-Inhibition of the Uric Acid Reabsorptive Transporter URAT1
Kazuki Fujita, Qiunan Zhu, Hiroshi Arakawa, Yoshiyuki Shirasaka and Ikumi Tamai

Drug Metabolism and Disposition August 29, 2023, DMD-AR-2023-001412; DOI: https://doi.org/10.1124/dmd.123.001412
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Exploring the boundaries for in vitro-in vivo extrapolation: Use of isolated hepatocytes in co-culture and impact of albumin binding properties in the prediction of clearance of various drug types
Laura Francis, Kayode Ogungbenro, Tom De Bruyn, J Brian Houston and David Hallifax

Drug Metabolism and Disposition August 14, 2023, DMD-AR-2023-001309; DOI: https://doi.org/10.1124/dmd.123.001309
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Goldenseal-mediated inhibition of intestinal uptake transporters decreases metformin systemic exposure in mice
Victoria O Oyanna, Kenisha Y Garcia-Torres, Baron J Bechtold, Katherine D Lynch, M Ridge Call, Miklós Horváth, Preston K Manwill, Tyler N Graf, Nadja B. Cech, Nicholas H. Oberlies, Mary F. Paine and John D. Clarke

Drug Metabolism and Disposition August 10, 2023, DMD-AR-2023-001360; DOI: https://doi.org/10.1124/dmd.123.001360
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The Utility of Mixed-Effects Models in the Evaluation of Complex Genomic Traits In Vitro
Nathan Alade, Abhinav Nath, Nina Isoherranen and Kenneth E. Thummel

Drug Metabolism and Disposition August 10, 2023, DMD-AR-2023-001260; DOI: https://doi.org/10.1124/dmd.123.001260
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CYP2D6 activity is correlated with changes in plasma concentrations of taurocholic acid during pregnancy and postpartum in CYP2D6 extensive metabolizers
Lindsay C Czuba, Karan Malhotra, Luke Enthoven, Emily E Fay, Sue L Moreni, Jennie Mao, Yuanyuan Shi, Weize Huang, Rheem A Totah, Nina Isoherranen and Mary F. Hebert

Drug Metabolism and Disposition August 7, 2023, DMD-AR-2023-001358; DOI: https://doi.org/10.1124/dmd.123.001358
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Human carboxylesterase 1A plays a predominant role in hydrolysis of the anti-dyslipidemia agent fenofibrate in humans
Hong-Xin Li, Meng-Ru Sun, Ya Zhang, Li-Lin Song, Feng Zhang, Yun-Qing Song, Xu-Dong Hou and Guang-Bo Ge

Drug Metabolism and Disposition August 7, 2023, DMD-AR-2023-001365; DOI: https://doi.org/10.1124/dmd.123.001365
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A comprehensive evaluation of the effects of RNA-editing proteins ADAR and ADARB1 on the expression of the drug-metabolizing enzymes in HepaRG cells
Joseph M Collins and Danxin Wang

Drug Metabolism and Disposition August 2, 2023, DMD-AR-2023-001396; DOI: https://doi.org/10.1124/dmd.123.001396

Commentaries

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Commentary Kirchhoff's Laws and Hepatic Clearance, Well-Stirred Model - Is There Common Ground?
Malcolm Rowland, Michael Weiss and K. Sandy Pang

Drug Metabolism and Disposition August 10, 2023, DMD-COM-2023-001300; DOI: https://doi.org/10.1124/dmd.123.001300

Minireview

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Potential and Challenges in Application of Physiologically Based Pharmacokinetic Modeling in Predicting Diarrheal Disease Impact on Oral Drug Pharmacokinetics
Cindy X. Zhang and Samuel L.M. Arnold

Drug Metabolism and Disposition September 15, 2023, DMD-MR-2022-000964; DOI: https://doi.org/10.1124/dmd.122.000964
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Metabolism and excretion of therapeutic peptides: current industry practices, perspectives, and recommendations
Minxia Michelle He, Sean Xiaochun Zhu, Joe R Cannon, Jesper Kammersgaard Christensen, Ruchia Duggal, Mithat Gunduz, Constanze Hilgendorf, Adam Hughes, Ivy Kekessie, Maximilian Kullmann, Dennis Leung, Carsten Terjung, Kai Wang and Frank Wesche

Drug Metabolism and Disposition August 17, 2023, DMD-AR-2023-001437; DOI: https://doi.org/10.1124/dmd.123.001437
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Central mechanisms of acetaminophen hepatotoxicity: mitochondrial dysfunction by protein adducts and oxidant stress
Hartmut Jaeschke and Anup Ramachandran

Drug Metabolism and Disposition August 11, 2023, DMD-MR-2023-001279; DOI: https://doi.org/10.1124/dmd.123.001279

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