Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

Articles

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Effect of Gender and Various Diets on Bile Acid Profile and Related Genes in Mice
Chong Ma, Ying Guo and Curtis D. Klaassen

Drug Metabolism and Disposition October 22, 2020, DMD-AR-2020-000166; DOI: https://doi.org/10.1124/dmd.120.000166
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Characterization of the human intestinal drug transport with Ussing chamber system incorporating freshly-isolated human jejunum
Kazuyoshi Michiba, Kazuya Maeda, Kou Kurimori, Tsuyoshi Enomoto, Osamu Shimomura, Tomoyo Takeuchi, Hiroyuki Nishiyama, Tatsuya Oda and Hiroyuki Kusuhara

Drug Metabolism and Disposition October 21, 2020, DMD-AR-2020-000138; DOI: https://doi.org/10.1124/dmd.120.000138
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Down-regulation of CYP1A2, CYP2B6, and CYP3A4 in human hepatocytes by prolyl hydroxylase domain 2 inhibitors via hypoxia-inducible factor-α stabilization
Hiroki Takano, Jun-ichi Yamaguchi, Sota Kato, Makoto Hamada, Mika Tada and Hiromi Endo

Drug Metabolism and Disposition October 21, 2020, DMD-AR-2020-000124; DOI: https://doi.org/10.1124/dmd.120.000124
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Histone Methyltransferase G9a Regulates Expression of Nuclear Receptors and Cytochrome P450 Enzymes in HepaRG Cells at Basal Level and in Fatty Acid Induced Steatosis.
Parimal Pande, Xiao-bo Zhong and Warren W. Ku

Drug Metabolism and Disposition October 19, 2020, DMD-AR-2020-000195; DOI: https://doi.org/10.1124/dmd.120.000195
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Development of a pharmacokinetic model of transplacental transfer of metformin to predict in vivo fetal exposure
Ken Kurosawa, Koji Chiba, Saki Noguchi, Tomohiro Nishimura and Masatoshi Tomi

Drug Metabolism and Disposition October 13, 2020, DMD-AR-2020-000127; DOI: https://doi.org/10.1124/dmd.120.000127
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Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach
Vineet Kumar, Mengyue Yin, Kazuya Ishida, Laurent Salphati, Cornelis E.C.A. Hop, Christopher Rowbottom, Guangqing Xiao, Yurong Lai, Anita Mathias, Xiaoyan Chu, W. Griffith Humphreys, Mingxiang Liao, Zsuzsanna Nerada, Nóra Szilvásy, Scott Heyward and Jashvant D. Unadkat

Drug Metabolism and Disposition October 13, 2020, DMD-AR-2020-000204; DOI: https://doi.org/10.1124/dmd.120.000204
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Pharmacokinetic and pharmacodynamic factors contribute to synergism between let-7c-5p and 5-fluorouracil in inhibiting hepatocellular carcinoma cell viability
Joseph L. Jilek, Mei-Juan Tu, Chao Zhang and Ai-Ming Yu

Drug Metabolism and Disposition October 13, 2020, DMD-AR-2020-000207; DOI: https://doi.org/10.1124/dmd.120.000207
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Differences in metformin and thiamine uptake between human and mouse organic cation transporter OCT1: structural determinants and potential consequences for intrahepatic concentrations
Marleen J. Meyer, Alzbeta Tuerkova, Sarah Römer, Christoph Wenzel, Tina Seitz, Jochen Gaedcke, Stefan Oswald, Jurgen Brockmöller, Barbara Zdrazil and Mladen V. Tzvetkov

Drug Metabolism and Disposition October 9, 2020, DMD-AR-2020-000170; DOI: https://doi.org/10.1124/dmd.120.000170
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In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In vitro to In vivo Extrapolation
Xiaomin Liang, Yeojin Park, Natalie DeForest, Jia Hao, Xiaofeng Zhao, Congrong Niu, Kelly Wang, Bill J Smith and Yurong Lai

Drug Metabolism and Disposition October 9, 2020, DMD-AR-2020-000163; DOI: https://doi.org/10.1124/dmd.120.000163
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Calibrating the in vitro-in vivo correlation for OATP mediated drug-drug interactions with rosuvastatin using static and PBPK models
Rucha Sane, Kit Wun Kathy Cheung, Péter Kovács, Taleah Farasyn, Ruina Li, Annamaria Bui, Luna Musib, Emese Kis, Emile Plise and Zsuzsanna Gáborik

Drug Metabolism and Disposition October 9, 2020, DMD-AR-2020-000149; DOI: https://doi.org/10.1124/dmd.120.000149
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Site Directed Mutagenesis at the MoCo Site of the Human Aldehyde Oxidase: Interrogating the Kinetic Differences Between Human and Cynomolgus Monkey
Armina Abbasi, Carolyn A. Joswig-Jones and Jeffrey P. Jones

Drug Metabolism and Disposition October 8, 2020, DMD-AR-2020-000187; DOI: https://doi.org/10.1124/dmd.120.000187
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A multi compartment human kidney proximal tubule-on-a-chip replicates cell polarization-dependent cisplatin toxicity
Tom T.G. Nieskens, Mikael Persson, Edward J. Kelly and Anna-Karin Sjögren

Drug Metabolism and Disposition October 5, 2020, DMD-AR-2020-000098; DOI: https://doi.org/10.1124/dmd.120.000098
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Cell type-specific roles of CD38 in the interactions of isoniazid with NAD⁺ in the liver
Junjie Zhu, Jie Lu, Hung-Chun Tung, Ke Liu, Jianhua Li, Denis M. Grant, Wen Xie and Xiaochao Ma

Drug Metabolism and Disposition October 5, 2020, DMD-AR-2020-000139; DOI: https://doi.org/10.1124/dmd.120.000139
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In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes
Kimberly Lapham, Ernesto Callegari, Julie Cianfrogna, Jian Lin, Mark Niosi, Christine C. Orozco, Raman Sharma and Theunis C. Goosen

Drug Metabolism and Disposition October 5, 2020, DMD-AR-2020-000171; DOI: https://doi.org/10.1124/dmd.120.000171
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Anti-Ly6E-seco-CBI-Dimer Antibody-Drug Conjugate (ADC) That Forms Adduct with Alpha-1-microglobulin (A1M) Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals
Victor Yip, Isabel Figueroa, Brandon Latifi, Shab Masih, Carl Ng, Doug Leipold, Amrita Kamath and Ben-Quan Shen

Drug Metabolism and Disposition October 5, 2020, DMD-AR-2020-000145; DOI: https://doi.org/10.1124/dmd.120.000145
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In vitro investigation, pharmacokinetics and disposition of imeglimin, a novel oral antidiabetic drug, in preclinical species and humans
Clémence Chevalier, Pascale Fouqueray and Sebastien Bolze

Drug Metabolism and Disposition October 5, 2020, DMD-AR-2020-000154; DOI: https://doi.org/10.1124/dmd.120.000154
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Revefenacin Absorption, Metabolism, and Excretion in Healthy Subjects and Pharmacological Activity of its Major Metabolite
David L. Bourdet, Suresh Yeola, Sharath S. Hegde, Pierre-Jean Colson, Chris N. Barnes and Marie T. Borin

Drug Metabolism and Disposition September 25, 2020, DMD-AR-2020-000103; DOI: https://doi.org/10.1124/dmd.120.000103
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Scaling Factors for Clearance in Adult Liver Cirrhosis
Eman El-Khateeb, Brahim Achour, Daniel Scotcher, Zubida M. Al-Majdoub, Varinder Athwal, Jill Barber and Amin Rostami-Hodjegan

Drug Metabolism and Disposition September 25, 2020, DMD-AR-2020-000152; DOI: https://doi.org/10.1124/dmd.120.000152
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Pharmacokinetics and Catabolism of [³H]TAK-164, a Guanylyl Cyclase C Targeted Antibody-Drug Conjugate
Jayaprakasam Bolleddula, Abhi Shah, Mohammad Shadid, Afrand Kamali, Michael D. Smith and Swapan K. Chowdhury

Drug Metabolism and Disposition August 25, 2020, DMD-AR-2020-000194; DOI: https://doi.org/10.1124/dmd.120.000194

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