Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

July 30, 2021

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Evaluation of Normothermic Machine Perfusion of Porcine Livers as a Novel Preclinical Model to Predict Biliary Clearance and Transporter-mediated Drug-Drug Interactions using Statins
Lianne J. Stevens, Andy Z.X. Zhu, Paresh P. Chothe, Swapan K. Chowdhury, Joanne M. Donkers, Wouter H.J. Vaes, Catherijne A.J. Knibbe, Ian P.J. Alwayn and Evita van de Steeg

Drug Metabolism and Disposition July 30, 2021, DMD-AR-2021-000521; DOI: https://doi.org/10.1124/dmd.121.000521
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Cytochrome b₅ Binds Tightly to Several Human Cytochrome P450 Enzymes
Donghak Kim, Vitchan Kim, Yasuhiro Tateishi and F. Peter Guengerich

Drug Metabolism and Disposition July 30, 2021, DMD-AR-2021-000475; DOI: https://doi.org/10.1124/dmd.121.000475
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Cytochrome P450-Catalyzed Metabolism of Cannabidiol to the Active Metabolite 7-Hydroxy-Cannabidiol
Jessica L Beers, Dong Fu and Klarissa D. Jackson

Drug Metabolism and Disposition July 30, 2021, DMD-AR-2020-000350; DOI: https://doi.org/10.1124/dmd.120.000350
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Quantitation of plasma membrane drug transporters in kidney tissue and cell lines using a novel proteomic approach enabled a prospective prediction of metformin disposition
Ryota Kikuchi, William J. Chiou, Kenneth R. Durbin, John P. Savaryn, Junli Ma, Arian Emami Riedmaier, Sonia M. de Morais, Gary J. Jenkins and Daniel A.J. Bow

Drug Metabolism and Disposition July 30, 2021, DMD-AR-2021-000487; DOI: https://doi.org/10.1124/dmd.121.000487

July 29, 2021

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Static and Dynamic Projections of Drug-Drug Interactions Caused by Cytochrome P450 3A Time-Dependent Inhibitors Measured in Human Liver Microsomes and Hepatocytes
Elaine Tseng, Heather Eng, Jian Lin, Matthew A. Cerny, David A. Tess, Theunis C. Goosen and R. Scott Obach

Drug Metabolism and Disposition July 29, 2021, DMD-AR-2021-000497; DOI: https://doi.org/10.1124/dmd.121.000497
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Infigratinib is a Reversible Inhibitor and Mechanism-based Inactivator of Cytochrome P450 3A4
Lloyd Wei Tat Tang, Jian Wei Teng, Siew Kwan Koh, Lei Zhou, Mei Lin Go, Eric Chun Yong Chan, Ravi Kumar Verma and Hao Fan

Drug Metabolism and Disposition July 29, 2021, DMD-AR-2021-000508; DOI: https://doi.org/10.1124/dmd.121.000508
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Tetrahydrocannabinol and Its Major Metabolites are Not (or are poor) Substrates or Inhibitors of Human P-glycoprotein (P-gp/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2)
Xin Chen, Jashvant D. Unadkat and Qingcheng Mao

Drug Metabolism and Disposition July 29, 2021, DMD-AR-2021-000505; DOI: https://doi.org/10.1124/dmd.121.000505

July 28, 2021

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Preclinical Drug Metabolism, Pharmacokinetic, and Pharmacodynamic Profiles of Ivosidenib, an Inhibitor of Mutant IDH1 for Treatment of IDH1-Mutant Malignancies
Yue Chen, Nelamangala V. Nagaraja, Bin Fan, Luke Utley, Rene M. Lemieux, Janeta Popovici-Muller, Lenny Dang, Hyeryun Kim, Liping Yan, Shin-San M. Su, Scott A. Biller and Hua Yang

Drug Metabolism and Disposition July 28, 2021, DMD-AR-2020-000234; DOI: https://doi.org/10.1124/dmd.120.000234

July 27, 2021

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Prediction of pregnancy-induced changes in secretory and total renal clearance of drugs transported by organic anion transporters
Jinfu Peng, Mayur K Ladumor and Jashvant D. Unadkat

Drug Metabolism and Disposition July 27, 2021, DMD-AR-2021-000557; DOI: https://doi.org/10.1124/dmd.121.000557

July 26, 2021

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Icotinib induces mechanism-based inactivation of rhCYP3A4/5 possibly via heme destruction by ketene intermediate
Chen Sun, Huimin Zhao, Wei Li, Yudi Jia, Yi Yang, Ying Peng and Jiang Zheng

Drug Metabolism and Disposition July 26, 2021, DMD-AR-2021-000369; DOI: https://doi.org/10.1124/dmd.121.000369

July 07, 2021

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Role of epoxide hydrolases and cytochrome P450s on metabolism of KZR-616, a first-in-class selective inhibitor of the immunoproteasome
Ying Fang, Henry Johnson, Janet L. Anderl, Tony Muchamuel, Dustin McMinn, Christophe Morisseau, Bruce D. Hammock, Christopher Kirk and Jinhai Wang

Drug Metabolism and Disposition July 7, 2021, DMD-AR-2020-000307; DOI: https://doi.org/10.1124/dmd.120.000307

June 29, 2021

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The Nonclinical Disposition and PK/PD Properties of GalNAc-conjugated siRNA Are Highly Predictable and Build Confidence in Translation to Man
Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher R. Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Christopher Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu

Drug Metabolism and Disposition June 29, 2021, DMD-MR-2021-000428; DOI: https://doi.org/10.1124/dmd.121.000428
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Characterization of Hepatic UDP-Glucuronosyl Transferase Enzyme Abundance - Activity Correlations and Population Variability using a Proteomics Approach and Comparison with Cytochrome P450 Enzymes
Ryan H. Takahashi, William F. Forrest, Alexander D. Smith, Justine Badée, NaHong Qiu, Stephan Schmidt, Abby C. Collier, Neil Parrott and Stephen Fowler

Drug Metabolism and Disposition June 29, 2021, DMD-AR-2021-000474; DOI: https://doi.org/10.1124/dmd.121.000474

June 28, 2021

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Silybin restored CYP3A expression through the SIRT2/NF-κB pathway in mouse nonalcoholic fatty liver disease
Ran Zhang, Dan Xu, Yirui Zhang, Rui Wang, Na Yang, Yunge Lou, Haokai Zhao, Jiye Aa, Guangji Wang and Yuan Xie

Drug Metabolism and Disposition June 28, 2021, DMD-AR-2021-000438; DOI: https://doi.org/10.1124/dmd.121.000438
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The inactivation of human aldehyde oxidase 1 by hydrogen peroxide and superoxide
Claudia Garrido and Silke Leimkuehler

Drug Metabolism and Disposition June 28, 2021, DMD-AR-2021-000549; DOI: https://doi.org/10.1124/dmd.121.000549
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Development of Robust QSAR Models for CYP2C9, CYP2D6, and CYP3A4 Catalysis and Inhibition
Eric Gonzalez, Sankalp Jain, Pranav Shah, Nao Torimoto-Katori, Alexey Zakharov, Ðắc-Trung Nguyễn, Srilatha Sakamuru, Ruili Huang, Menghang Xia, R. Scott Obach, Cornelis E.C.A. Hop, Anton Simeonov and Xin Xu

Drug Metabolism and Disposition June 28, 2021, DMD-AR-2020-000320; DOI: https://doi.org/10.1124/dmd.120.000320

June 23, 2021

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MicroRNAs in apple-derived nanoparticles modulate intestinal expression of OATP2B1/SLCO2B1 in Caco-2 cells
Hisakazu Komori, Daichi Fujita, Yuma Shirasaki, Qiunan Zhu, Yui Iwamoto, Takeo Nakanishi, Miki Nakajima and Ikumi Tamai

Drug Metabolism and Disposition June 23, 2021, DMD-AR-2021-000380; DOI: https://doi.org/10.1124/dmd.121.000380
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Oleuropein-induced acceleration of CYP-catalyzed drug metabolism: central role for nuclear receptor PPARα
Foteini Malliou, Christina E. Andriopoulou, Frank J. Gonzalez, Aristeidis Kofinas, Alexios-Leandros Skaltsounis and Maria Konstandi

Drug Metabolism and Disposition June 23, 2021, DMD-AR-2020-000302; DOI: https://doi.org/10.1124/dmd.120.000302
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Contribution of extra-hepatic aldehyde oxidase activity to human clearance
Kirk D. Kozminski, Jangir Selimkhanov, Scott Heyward and Michael A. Zientek

Drug Metabolism and Disposition June 23, 2021, DMD-AR-2020-000313; DOI: https://doi.org/10.1124/dmd.120.000313
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Comparative hepatic and intestinal efflux transport of statins
Feng Deng, Suvi-Kukka Tuomi, Mikko Neuvonen, Päivi Hirvensalo, Sami Kulju, Christoph Wenzel, Stefan Oswald, Anne M. Filppula and Mikko Niemi

Drug Metabolism and Disposition June 23, 2021, DMD-AR-2021-000430; DOI: https://doi.org/10.1124/dmd.121.000430

June 21, 2021

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Leveraging Physiologically-Based Pharmacokinetic (PBPK) Modeling and Experimental Data to Guide Dosing Modification of CYP3A-Mediated Drug-Drug Interactions (DDIs) in the Pediatric Population
Sara N. Salerno, Fernando O. Carreño, Andrea N. Edginton, Michael Cohen-Wolkowiez and Daniel Gonzalez

Drug Metabolism and Disposition June 21, 2021, DMD-AR-2020-000318; DOI: https://doi.org/10.1124/dmd.120.000318

June 16, 2021

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Differences in hydrolase activities in the liver and small intestine between marmosets and humans
Shiori Honda, Tatsuki Fukami, Keiya Hirosawa, Takuya Tsujiguchi, Yongjie Zhang, Masataka Nakano, Shotaro Uehara, Yasuhiro Uno, Hiroshi Yamazaki and Miki Nakajima

Drug Metabolism and Disposition June 16, 2021, DMD-AR-2021-000513; DOI: https://doi.org/10.1124/dmd.121.000513
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Messenger RNA expression of albumin, transferrin, transthyretin, asialoglycoprotein receptor, P450 isoform, uptake transporter and efflux transporter genes as a function of culture duration in prolonged cultured cryopreserved human hepatocytes from 7 donors as collagen-matrigel sandwich cultures: Evidence for redifferentiation upon prolonged culturing
Qian Yang and Albert P. Li

Drug Metabolism and Disposition June 16, 2021, DMD-AR-2021-000424; DOI: https://doi.org/10.1124/dmd.121.000424
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Impact of inter-individual differences in plasma fraction unbound on the pharmacokinetics of a novel Syk kinase inhibitor in Beagle dogs
Andy Pike, Barry Jones, Roshini Markandu and Daniel O'Neill

Drug Metabolism and Disposition June 16, 2021, DMD-AR-2021-000409; DOI: https://doi.org/10.1124/dmd.121.000409

June 01, 2021

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Metabolism and hepatotoxicity of pyrazinamide, an anti-tuberculosis drug
Zahir Hussain, Junjie Zhu and Xiaochao Ma

Drug Metabolism and Disposition June 1, 2021, DMD-MR-2021-000389; DOI: https://doi.org/10.1124/dmd.121.000389
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Times New Roman',serif;">Characterization of a novel CYP1A2 knockout rat model constructed by CRISPR/Cas9
Dongyi Sun, Jian Lu, Yuanjin Zhang, Jie Liu, Zongjun Liu, Bingyi Yao, Yuanqing Guo and Xin Wang

Drug Metabolism and Disposition June 1, 2021, DMD-AR-2021-000403; DOI: https://doi.org/10.1124/dmd.121.000403
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BCRP/ABCG2 Transporter Regulates Accumulation of Cadmium in Kidney Cells: Role of the Q141K Variant in Modulating Nephrotoxicity
Xia Wen, Danielle Kozlosky, Ranran Zhang, Cathleen Doherty, Brian Buckley, Emily Barrett and Lauren M. Aleksunes

Drug Metabolism and Disposition June 1, 2021, DMD-AR-2021-000446; DOI: https://doi.org/10.1124/dmd.121.000446
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Quantitative investigation of irinotecan metabolism, transport and gut microbiome activation
Md Masud Parvez, Abdul Basit, Parth B. Jariwala, Zsuzsanna Gáborik, Emese Kis, Scott Heyward, Matthew R. Redinbo and Bhagwat Prasad

Drug Metabolism and Disposition June 1, 2021, DMD-AR-2021-000476; DOI: https://doi.org/10.1124/dmd.121.000476

May 27, 2021

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Proteomic Quantification of Changes in Abundance of Drug-Metabolizing Enzymes and Drug Transporters in Human Liver Cirrhosis: Different Methods, Similar Outcomes
Eman El-Khateeb, Zubida M. Al-Majdoub, Amin Rostami-Hodjegan, Jill Barber and Brahim Achour

Drug Metabolism and Disposition May 27, 2021, DMD-AR-2021-000484; DOI: https://doi.org/10.1124/dmd.121.000484
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Comparative hepatic and intestinal metabolism and pharmacodynamics of statins
Anne M. Filppula, Päivi Hirvensalo, Heli Parviainen, Vilma E. Ivaska, K. Ivar Lönnberg, Feng Deng, Jenni Viinamäki, Mika Kurkela, Mikko Neuvonen and Mikko Niemi

Drug Metabolism and Disposition May 27, 2021, DMD-AR-2021-000406; DOI: https://doi.org/10.1124/dmd.121.000406

May 25, 2021

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Deconvolution of CYP Induction Mechanisms in HepaRG Nuclear Hormone Receptor Knockout Cells
Lena C. Preiss, Ruoqi Liu, Philip Hewitt, David Thompson, Katrin Georgi, Lassina Badolo, Volker M. Lauschke and Carl Petersson

Drug Metabolism and Disposition May 25, 2021, DMD-AR-2020-000333; DOI: https://doi.org/10.1124/dmd.120.000333
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3,3'-Diindolylmethane (BioResponse DIM^®) Exhibits Significant Metabolism Following Oral Dosing in Humans
Monica L. Vermillion Maier, Lisbeth K. Siddens, Sandra L. Uesugi, Jaewoo Choi, Scott W. Leonard, Jamie M. Pennington, Susan C. Tilton, Jordan N. Smith, Emily Ho, H.H. Sherry Chow, Bach D. Nguyen, Siva K. Kolluri and David E. Williams

Drug Metabolism and Disposition May 25, 2021, DMD-AR-2020-000346; DOI: https://doi.org/10.1124/dmd.120.000346

May 24, 2021

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Passive influx and ion trapping are more relevant to the cellular accumulation of highly permeable low molecular weight acidic drugs than is Organic Anion Transporter 2 (OAT2)
Dallas Bednarczyk

Drug Metabolism and Disposition May 24, 2021, DMD-AR-2021-000425; DOI: https://doi.org/10.1124/dmd.121.000425

May 19, 2021

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Pharmacokinetics, disposition, and biotransformation of [¹⁴C]-omecamtiv mecarbil in healthy male subjects after a single intravenous or oral dose.
Ashit Trivedi, Jan Wahlstrom, Mia Mackowski, Sandeep Dutta and Edward Lee

Drug Metabolism and Disposition May 19, 2021, DMD-AR-2021-000444; DOI: https://doi.org/10.1124/dmd.121.000444
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Negative Regulation of Human Hepatic Constitutive Androstane Receptor by Cholesterol Synthesis Inhibition: Role of Sterol Regulatory Element Binding Proteins
Liberta Cuko, Zofia Duniec-Dmuchowski, Elizabeth A. Rondini, Asmita Pant, John K. Fallon, Elizabeth M. Wilson, Nicholas J. Peraino, Judy A. Westrick, Philip C. Smith and Thomas A. Kocarek

Drug Metabolism and Disposition May 19, 2021, DMD-AR-2020-000341; DOI: https://doi.org/10.1124/dmd.120.000341
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Investigation into MAO B-mediated formation of CC112273, a major circulating metabolite of ozanimod, in humans and preclinical species: Stereospecific oxidative deamination of (S)-enantiomer of indaneamine (RP101075) by MAO B
April Bai, Veerabahu .Shanmugasundaram, Julie V. Selkirk, Sekhar Surapaneni and Deepak Dalvie

Drug Metabolism and Disposition May 19, 2021, DMD-AR-2021-000447; DOI: https://doi.org/10.1124/dmd.121.000447

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