Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

May 07, 2021

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A new intestinal model for analysis of drug absorption and interactions considering physiological translocation of contents
Satoshi Asano, Aoi Yoshitomo, Shizuka Hozuki, Hiromi Sato, Yasuhiro Kazuki and Akihiro Hisaka

Drug Metabolism and Disposition May 7, 2021, DMD-AR-2021-000361; DOI: https://doi.org/10.1124/dmd.121.000361

May 06, 2021

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Improving the Translation of Organic Anion Transporting Polypeptide Substrates using HEK293 Cell Data in the Presence and Absence of Human Plasma via PBPK Modeling
Christine M. Bowman, Buyun Chen, Jonathan Cheong, Liling Liu, Yuan Chen and Jialin Mao

Drug Metabolism and Disposition May 6, 2021, DMD-AR-2020-000315; DOI: https://doi.org/10.1124/dmd.120.000315

May 05, 2021

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Comparative proteomics analysis of the post-mitochondrial supernatant fraction of human lens-free whole eye and liver
Ankit Balhara, Abdul Basit, Upendra A. Argikar, Jennifer L. Dumouchel, Saranjit Singh and Bhagwat Prasad

Drug Metabolism and Disposition May 5, 2021, DMD-AR-2020-000297; DOI: https://doi.org/10.1124/dmd.120.000297
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Evaluation of the Absorption, Metabolism, and Excretion of a Single Oral 1 mg Dose of Tropifexor in Healthy Male Subjects and the Concentration Dependency of Tropifexor Metabolism
Lydia Wang-Lakshman, Zhuang Miao, Lai Wang, Helen Gu, Mark Kagan, Jessie Gu, Elizabeth McNamara, Markus Walles, Ralph Woessner, Gian Camenisch, Heidi J. Einolf and Jin Chen

Drug Metabolism and Disposition May 5, 2021, DMD-AR-2020-000349; DOI: https://doi.org/10.1124/dmd.120.000349
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Development and verification of a linked ᵪB;⁹-THC/11-OH-THC physiologically-based pharmacokinetic (PBPK) model in healthy, non-pregnant population and extrapolation to pregnant women
Gabriela I. Patilea-Vrana and Jashvant D. Unadkat

Drug Metabolism and Disposition May 5, 2021, DMD-AR-2020-000322; DOI: https://doi.org/10.1124/dmd.120.000322

May 04, 2021

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Nonclinical Pharmacokinetics and ADME of Givosiran, the First Approved GalNAc-conjugated RNAi Therapeutic
Jing Li, Ju Liu, Xuemei Zhang, Valerie Clausen, Chris Tran, Michael Arciprete, Qianfan Wang, Carrie Rocca, Li-Hua Guan, Guodong Zhang, Diana Najarian, Yuanxin Xu, Peter Smith, Jing-Tao Wu and Saeho Chong

Drug Metabolism and Disposition May 4, 2021, DMD-AR-2021-000381; DOI: https://doi.org/10.1124/dmd.121.000381

May 03, 2021

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Preliminary Flow Modeling by Hybrid Automata Alternating Continuous Reaction and Discrete Transit for Pharmacokinetics
Satoshi Koyama

Drug Metabolism and Disposition May 3, 2021, DMD-AR-2020-000227; DOI: https://doi.org/10.1124/dmd.120.000227

April 16, 2021

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Investigating the Utility of Humanized PXR-CAR-CYP3A4/7 Mouse Model to Assess CYP3A-Mediated Induction
Justin Q. Ly, Susan Wong, Liling Liu, Ruina Li, Kirsten Messick and Jae H. Chang

Drug Metabolism and Disposition April 16, 2021, DMD-AR-2021-000439; DOI: https://doi.org/10.1124/dmd.121.000439

April 06, 2021

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IVIVE of Transporter-Mediated Renal Clearance: Relative Expression Factor (REF) vs Relative Activity Factor (RAF) Approach
Aditya R. Kumar, Bhagwat Prasad, Deepak Kumar Bhatt, Sumathy Mathialagan, Manthena V. S. Varma and Jashvant D. Unadkat

Drug Metabolism and Disposition April 6, 2021, DMD-AR-2021-000367; DOI: https://doi.org/10.1124/dmd.121.000367

April 02, 2021

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Reversible and irreversible inhibition of cytochrome P450 enzymes by methylophiopogonanone A
Dong-Zhu Tu, Xu Mao, Feng Zhang, Rong-Jing He, Jing-Jing Wu, Yue Wu, Xiao-Hua Zhao, Jiang Zheng and Guang-Bo Ge

Drug Metabolism and Disposition April 2, 2021, DMD-AR-2020-000325; DOI: https://doi.org/10.1124/dmd.120.000325
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Cytochrome P450 3A Time-Dependent Inhibition Assays are Too Sensitive for Identification of Drugs Causing Clinically Significant Drug-Drug Interactions: A Comparison of Human Liver Microsomes and Hepatocytes and Definition of Boundaries for Inactivation Rate Constants
Heather Eng, Elaine Tseng, Matthew A. Cerny, Theunis C. Goosen and R. Scott Obach

Drug Metabolism and Disposition April 2, 2021, DMD-AR-2021-000356; DOI: https://doi.org/10.1124/dmd.121.000356
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Pharmacokinetic and biochemical profiling of Sodium Dichloroacetate in pregnant ewes and fetuses
Serene Joseph, Abhisheak Sharma, Lloyd P. Horne, Charles E. Wood, Taimour Langaee, Margaret O. James, Peter W. Stacpoole and Maureen Keller-Wood

Drug Metabolism and Disposition April 2, 2021, DMD-AR-2020-000330; DOI: https://doi.org/10.1124/dmd.120.000330

March 30, 2021

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Metabolism and Mass Balance of the Novel Nonsteroidal Androgen Receptor Inhibitor Darolutamide in Humans
Päivi Taavitsainen, Olaf Prien, Marja Kähkönen, Michael Niehues, Timo Korjamo, Karsten Denner, Pirjo Nykänen, Annamari Vuorela, Natalia A. Jungmann, Clemens-Jeremias von Bühler, Mikko Koskinen, Christian Zurth and Hille Gieschen

Drug Metabolism and Disposition March 30, 2021, DMD-AR-2020-000309; DOI: https://doi.org/10.1124/dmd.120.000309

March 24, 2021

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Dual action of acidic microenvironment on the enrichment of the active metabolite of disulfiram in tumor tissues
Chongzhuang Tang, Xiaoyan Pang, Zitao Guo, Runcong Guo, Lu Liu and Xiaoyan Chen

Drug Metabolism and Disposition March 24, 2021, DMD-AR-2020-000317; DOI: https://doi.org/10.1124/dmd.120.000317

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