Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

January 27, 2023

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Detection and characterization of in vitro payload-containing catabolites of non-cleavable ADCs by high-resolution mass spectrometry and multiple data-mining tools
Tingting Cai, Liqi Shi, Huihui Guo, Ruixing Li, Weiqun Cao, Liang Shen, Mingshe Zhu and Yi Tao

Drug Metabolism and Disposition January 27, 2023, DMD-AR-2022-001135; DOI: https://doi.org/10.1124/dmd.122.001135

January 20, 2023

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Impact of direction of transport on the evaluation of substrate recognition of mouse multidrug and toxin extrusion protein 1 (mMate1)
Asami Saito, Tomoko Kito, Naoki Ishiguro, Masahito Takatani, Takashi Kudo, Bojan Bister and Hiroyuki Kusuhara

Drug Metabolism and Disposition January 20, 2023, DMD-AR-2022-001115; DOI: https://doi.org/10.1124/dmd.122.001115
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Newly Identified Tree Shrew Cytochrome P450 2A13 (CYP2A13) is Expressed in Liver and Lung and Encodes a Functional Drug-Metabolizing Enzyme Similar to Dog CYP2A13 and Pig CYP2A19
Genki Ushirozako, Yutaro Noda, Norie Murayama, Hiroaki Kawaguchi, Kyoko Tsukiyama-Kohara, Hiroshi Yamazaki and Yasuhiro Uno

Drug Metabolism and Disposition January 20, 2023, DMD-AR-2022-001152; DOI: https://doi.org/10.1124/dmd.122.001152

January 18, 2023

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Biotransformation of the Novel Myeloperoxidase Inhibitor AZD4831 in Preclinical Species and Humans
Ulrik Jurva, Lars Weidolf, Ann-Sofie Sandinge, Carina Leandersson, Anja Ekdahl, Xue-Qing Li, Thomas Antonsson, Johan Sundell, Kristina Westerlund, Carl Amilon, Tord Inghardt and V. Sashi Gopaul

Drug Metabolism and Disposition January 18, 2023, DMD-AR-2022-001099; DOI: https://doi.org/10.1124/dmd.122.001099
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Unusual Biotransformation Reactions of Drugs and Drug Candidates
Emre M. Isin

Drug Metabolism and Disposition January 18, 2023, DMD-MR-2021-000744; DOI: https://doi.org/10.1124/dmd.121.000744
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Fifty years of aryl hydrocarbon receptor research as reflected in the pages of Drug Metabolism and Disposition
David S. Riddick

Drug Metabolism and Disposition January 18, 2023, DMD-MR-2022-001009; DOI: https://doi.org/10.1124/dmd.122.001009

January 13, 2023

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Predictive Performance of Physiologically Based Pharmacokinetic Modelling of Beta-Lactam Antibiotic Concentrations in Adipose, Bone and Muscle Tissues
Pieter-Jan De Sutter, Pieter De Cock, Trevor N. Johnson, Helen Musther, Elke Gasthuys and An Vermeulen

Drug Metabolism and Disposition January 13, 2023, DMD-AR-2022-001129; DOI: https://doi.org/10.1124/dmd.122.001129
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Application of Accelerator Mass Spectrometry to Characterize the Mass Balance Recovery and Disposition of AZD4831, a Novel Myeloperoxidase Inhibitor, Following Administration of an Oral Radiolabeled Microtracer Dose in Humans
Chandrali Bhattacharya, Ann-Sofie Sandinge, Ryan A. Bragg, Maria Heijer, Jingjing Yan, Linda C. Andersson, Ulrik Jurva, Marta Pelay-Gimeno, Wouter H.J. Vaes, Rianne A.F. de Ligt, Malin Gränfors, Carl Amilon, Eva-Lotte Lindstedt, Somasekhara R. Menakuru, Pavlo Garkaviy, Lars Weidolf and V. Sashi Gopaul

Drug Metabolism and Disposition January 13, 2023, DMD-AR-2022-001100; DOI: https://doi.org/10.1124/dmd.122.001100

January 10, 2023

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Achieving a deeper understanding of drug metabolism and responses using single cell technologies
Abigail M. Wheeler, Colten D. Eberhard, Eric P. Mosher, Yuting Yuan, Hannah N. Wilkins, Herana Kamal Seneviratne, Benjamin C. Orsburn and Namandje N. Bumpus

Drug Metabolism and Disposition January 10, 2023, DMD-MR-2022-001043; DOI: https://doi.org/10.1124/dmd.122.001043

January 09, 2023

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Biotransformation of efavirenz and proteomic analysis of P450s and UGTs in mouse, macaque, and human brain-derived in vitro systems
Abigail M. Wheeler, Benjamin C. Orsburn and Namandje N. Bumpus

Drug Metabolism and Disposition January 9, 2023, DMD-AR-2022-001195; DOI: https://doi.org/10.1124/dmd.122.001195
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Relevance of Human Aldoketoreductases and Microbial β-Glucuronidases in Testosterone Disposition
Abdul Basit, John K. Amory, Vijaya Saradhi Mettu, Cindy Yanfei Li, Scott Heyward, Parth B. Jariwala, Matthew R. Redinbo and Bhagwat Prasad

Drug Metabolism and Disposition January 9, 2023, DMD-AR-2022-000975; DOI: https://doi.org/10.1124/dmd.122.000975
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Process and System Clearances in Pharmacokinetic Models: Our Basic Clearance Concepts are Correct
Ken Korzekwa and Swati Nagar

Drug Metabolism and Disposition January 9, 2023, DMD-MR-2022-001060; DOI: https://doi.org/10.1124/dmd.122.001060
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The Unique Human N10-Glucuronidated Metabolite Formation from Olanzapine in Chimeric NOG-TKm30 Mice with Humanized Livers
Shotaro Uehara, Yuichiro Higuchi, Nao Yoneda, Hiroaki Kato, Hiroshi Yamazaki and Hiroshi Suemizu

Drug Metabolism and Disposition January 9, 2023, DMD-AR-2022-001102; DOI: https://doi.org/10.1124/dmd.122.001102
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Absorption, Metabolism, and Excretion of Taselisib (GDC-0032), a Potent β-sparing PI3K Inhibitor, in Rats, Dogs, and Humans
Shuguang Ma, Sungjoon Cho, Srikumar Sahasranaman, Weiping Zhao, Jodie Pang, Xiao Ding, Brian Dean, Bin Wang, Jerry Y Hsu, Joseph Ware and Laurent Salphati

Drug Metabolism and Disposition January 9, 2023, DMD-AR-2022-001096; DOI: https://doi.org/10.1124/dmd.122.001096
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CYP3A4 and CYP3A5 expression is regulated by CYP3A4*1G in CRISPR/Cas9 edited HepG2 cells
Weihong Yang, Huan Zhao, Yaojie Dou, Pei Wang, Qi Chang, Xiaomeng Qiao, Xiaofei Wang, Chen Xu, Zhe Zhang and Lirong Zhang

Drug Metabolism and Disposition January 9, 2023, DMD-AR-2022-001111; DOI: https://doi.org/10.1124/dmd.122.001111
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Antibiotics-induced depletion of rat microbiota induces changes in the expression of host drug-processing genes and pharmacokinetic behaviors of CYPs probe drugs
Haijun Yang, Yanjuan Zhang, Rong Zhou, Tianyuan Wu, Peng Zhu, Yujie Liu, Jian Zhou, Yalan Xiong, Yanling Xiong, Honghao Zhou, Wei Zhang, Yan Shu, Xiong Li and Qing Li

Drug Metabolism and Disposition January 9, 2023, DMD-AR-2022-001173; DOI: https://doi.org/10.1124/dmd.122.001173

December 07, 2022

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Contribution of UGT enzymes to human drug metabolism stereoselectivity: a case study of medetomidine, RO5263397, propranolol and testosterone
Nicolò Milani, NaHong Qiu and Stephen Fowler

Drug Metabolism and Disposition December 7, 2022, DMD-AR-2022-001024; DOI: https://doi.org/10.1124/dmd.122.001024
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Pharmacokinetic/pharmacodynamic models of an Alzheimer's drug, donepezil, in rats
Akiko Kiriyama, Shunsuke Kimura and Shugo Yamashita

Drug Metabolism and Disposition December 7, 2022, DMD-AR-2022-001061; DOI: https://doi.org/10.1124/dmd.122.001061
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Significance of basal membrane permeability of epithelial cells in predicting intestinal drug absorption
Aoi Yoshitomo, Satoshi Asano, Shizuka Hozuki, Yuta Tamemoto, Yukihiro Shibata, Natsumi Hashimoto, Keita Takahashi, Yoko Sasaki, Naoka Ozawa, Michiharu Kageyama, Takeshi Iijima, Yasuhiro Kazuki, Hiromi Sato and Akihiro Hisaka

Drug Metabolism and Disposition December 7, 2022, DMD-AR-2022-000907; DOI: https://doi.org/10.1124/dmd.122.000907

December 02, 2022

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Opportunities for accelerating drug discovery and development by using engineered drug-metabolizing enzymes
Elizabeth M. J. Gillam and Valerie M Kramlinger

Drug Metabolism and Disposition December 2, 2022, DMD-MR-2021-000743; DOI: https://doi.org/10.1124/dmd.121.000743
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Comprehensive analyses of the intracellular and in vivo disposition of Fab-siRNA conjugate to identify key issues to improve its in vivo activity
Asami Toshima, Yasuhisa Shiraishi, Daisuke Shinmi, Yoshiyuki Kagawa and Junichi Enokizono

Drug Metabolism and Disposition December 2, 2022, DMD-AR-2022-001098; DOI: https://doi.org/10.1124/dmd.122.001098
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Quantitative CYP3A4 induction risk assessment using human hepatocytes complemented with pregnane X receptor (PXR)-activating profiles
Aynur Ekiciler, Wen Li Kelly Chen, Yan Bo, Alessandra Pugliano, Massimiliano Donzelli, Neil Parrott and Kenichi Umehara

Drug Metabolism and Disposition December 2, 2022, DMD-AR-2022-001132; DOI: https://doi.org/10.1124/dmd.122.001132
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Intravital microscopy reveals unforeseen biodistribution within the liver and kidney mechanistically connected to the clearance of a bifunctional antibody
Amita Datta-Mannan, Bruce A. Molitoris, Yiqing Feng, Michelle M. Martinez, Ruben M. Sandoval, Robin M Brown, Daniel Merkel, Johnny E. Croy and Kenneth W. Dunn

Drug Metabolism and Disposition December 2, 2022, DMD-AR-2022-001049; DOI: https://doi.org/10.1124/dmd.122.001049

November 29, 2022

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Quantification of accurate composition and total abundance of homologous proteins by conserved-plus-surrogate peptide (CPSP) approach: Quantification of UDP glucuronosyltransferases in human tissues
Deepak Ahire, Mitesh Patel, Sujal V Deshmukh and Bhagwat Prasad

Drug Metabolism and Disposition November 29, 2022, DMD-AR-2022-001155; DOI: https://doi.org/10.1124/dmd.122.001155
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Maternal and Fetal Exposure to (-)-Δ⁹-tetrahydrocannabinol and Its Major Metabolites in Pregnant Mice Is Differentially Impacted by P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP)
Xin Chen, Jashvant D. Unadkat and Qingcheng Mao

Drug Metabolism and Disposition November 29, 2022, DMD-AR-2022-001110; DOI: https://doi.org/10.1124/dmd.122.001110
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Cell and tissue specific metabolism of nucleoside and nucleotide drugs: case studies and implications for precision medicine
Elaine E To

Drug Metabolism and Disposition November 29, 2022, DMD-MR-2022-000856; DOI: https://doi.org/10.1124/dmd.122.000856
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Hydroxychloroquine is metabolized by CYP2D6, CYP3A4, and CYP2C8, and inhibits CYP2D6, while its metabolites also inhibit CYP3A in vitro
Marie-Noëlle Paludetto, Mika Kurkela, Helinä Kahma, Janne T. Backman, Mikko Niemi and Anne M. Filppula

Drug Metabolism and Disposition November 29, 2022, DMD-AR-2022-001018; DOI: https://doi.org/10.1124/dmd.122.001018

November 23, 2022

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Multidisciplinary Insights into the Structure-Function Relationship of the CYP2B6 Active Site
Ethan D. Angle and Philip M Cox

Drug Metabolism and Disposition November 23, 2022, DMD-MR-2022-000853; DOI: https://doi.org/10.1124/dmd.122.000853

November 17, 2022

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Nucleoside Triphosphate Diphosphohydrolase 1 Exhibits Enzymatic Activity Toward Tenofovir Diphosphate
Herana Kamal Seneviratne

Drug Metabolism and Disposition November 17, 2022, DMD-AR-2022-000855; DOI: https://doi.org/10.1124/dmd.122.000855

November 15, 2022

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A physiological-based pharmacokinetic model embedded with a target-mediated drug disposition mechanism can characterize single dose warfarin pharmacokinetic profiles in subjects with various CYP2C9 genotypes under different co-treatments
Shen Cheng, Darcy R Flora, Allan E. Rettie, Richard C. Brundage and Timothy S. Tracy

Drug Metabolism and Disposition November 15, 2022, DMD-AR-2022-001048; DOI: https://doi.org/10.1124/dmd.122.001048

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