Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

December 01, 2023

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Effect of cimetidine on metformin pharmacokinetics and endogenous metabolite levels in rats
Anoud Sameer Ailabouni, Vijaya Saradhi Mettu, Aarzoo Thakur, Dilip Kumar Singh and Bhagwat Prasad

Drug Metabolism and Disposition December 1, 2023, DMD-AR-2023-001470; DOI: https://doi.org/10.1124/dmd.123.001470
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Preclinical Characterization of Catabolic Pathways and Metabolism of ABBV-011, a Novel Calicheamicin-Based SEZ6 Targeting Antibody Drug Conjugate
Daniel Ladror, Christine Gu, Vince Tong, Alexander Schammel, Julia Gavrilyuk, Anthony Haight and Hetal Sarvaiya

Drug Metabolism and Disposition December 1, 2023, DMD-AR-2023-001516; DOI: https://doi.org/10.1124/dmd.123.001516
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Association between gadoxetic acid-enhanced MR imaging, organic anion transporters, and farnesoid X receptor in benign focal liver lesions
Belle V van Rosmalen, Michele Visentin, Alicia Furumaya, Otto M van Delden, Geert Kazemier, Thomas M van Gulik, Joanne Verheij and Bruno Stieger

Drug Metabolism and Disposition December 1, 2023, DMD-AR-2023-001492; DOI: https://doi.org/10.1124/dmd.123.001492
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Good cells go bad: immune dysregulation in the transition from acute liver injury to liver failure after acetaminophen overdose
James P. Luyendyk, Elena Morozova and Bryan L. Copple

Drug Metabolism and Disposition December 1, 2023, DMD-MR-2023-001280; DOI: https://doi.org/10.1124/dmd.123.001280
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Evaluating drug-drug interaction risk associated with peptide analogues using advanced in vitro systems
Rune Aa Nørgaard, Deepak K Bhatt, Erkka Järvinen, Tore B Stage, Charlotte Gabel-Jensen, Aleksandra Galetin and Carolina Säll

Drug Metabolism and Disposition December 1, 2023, DMD-AR-2023-001441; DOI: https://doi.org/10.1124/dmd.123.001441

November 29, 2023

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Novel independent trans- and cis-genetic variants associated with CYP2D6 expression and activity in human livers
Dylan Smith, Bing He, Jian Shi, Hao-Jie Zhu and Xinwen Wang

Drug Metabolism and Disposition November 29, 2023, DMD-AR-2023-001548; DOI: https://doi.org/10.1124/dmd.123.001548
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Comparison of 1beta- and 5beta-hydroxylation of Deoxycholate and Glycodeoxycholate as In Vitro Index Reactions for CYP3A Activities
Cuitong Wang, Bin Cheng, Wei Wei, Lanlan Gui, Wushuang Zeng, Yutong Wang, Yixuan Wang, Qi Chen, Liang Xu, Jia Miao and Ke Lan

Drug Metabolism and Disposition November 29, 2023, DMD-AR-2023-001513; DOI: https://doi.org/10.1124/dmd.123.001513

November 16, 2023

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Deciphering the role of fatty acid metabolizing CYP4F11 in lung cancer and its potential as a drug target
Huiting Jia, Bjoern Brixius, Caleb Bocianoski, Sutapa Ray, David R. Koes and Simone Brixius-Anderko

Drug Metabolism and Disposition November 16, 2023, DMD-AR-2023-001463; DOI: https://doi.org/10.1124/dmd.123.001463

November 14, 2023

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Involvement of proton-coupled SLC49A4-mediated transport in the export of lysosomally trapped pyrilamine
Shogo Akino, Tomoya Yasujima, Rei Shibutani, Takahiro Yamashiro and Hiroaki Yuasa

Drug Metabolism and Disposition November 14, 2023, DMD-AR-2023-001354; DOI: https://doi.org/10.1124/dmd.123.001354

November 06, 2023

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Time-Dependent Inhibition of CYP1A2 by Stiripentol and Structurally Related Methylenedioxyphenyl Compounds via Metabolic Intermediate Complex Formation
Yasuhiro Masubuchi, Chieko Takahashi and Rina Gendo

Drug Metabolism and Disposition November 6, 2023, DMD-AR-2023-001511; DOI: https://doi.org/10.1124/dmd.123.001511

November 02, 2023

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The Role of Mechanistic Biomarkers in Understanding Acetaminophen Hepatotoxicity in Humans
Mitchell R. McGill

Drug Metabolism and Disposition November 2, 2023, DMD-MR-2023-001281; DOI: https://doi.org/10.1124/dmd.123.001281

October 26, 2023

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Construction of humanized CYP1A2 rats using CRISPR/Cas9 to promote drug metabolism and pharmacokinetic research
Jie Liu, Jian Lu, Bingyi Yao, Yuanjin Zhang, Shengbo Huang, Xi Chen, Yifei Shen and Xin Wang

Drug Metabolism and Disposition October 26, 2023, DMD-AR-2023-001500; DOI: https://doi.org/10.1124/dmd.123.001500
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Characterizing the distribution of a STING agonist and its metabolites in mouse liver by MALDI imaging mass spectrometry
Fang Xie, Tracy Gales, Mike Ringenberg, Amaya I. Wolf and M. Reid Groseclose

Drug Metabolism and Disposition October 26, 2023, DMD-AR-2022-001076; DOI: https://doi.org/10.1124/dmd.122.001076

October 25, 2023

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PBPK Modelling for Drugs Cleared by Non-CYP Enzymes: State-of-the-Art and Future Perspectives
Agustos C. Ozbey, Stephen Fowler, Karen Leys, Pieter Annaert, Kenichi Umehara and Neil Parrott

Drug Metabolism and Disposition October 25, 2023, DMD-AR-2023-001487; DOI: https://doi.org/10.1124/dmd.123.001487
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Pharmacokinetic Models Scaled-up from Humanized-liver Mouse Data Can Account for Drug Monitoring Results of Atomoxetine and Its 4-Hydroxylated and N-Demethylated Metabolites in Pediatric Patients Genotyped for Cytochrome P450 2D6
Makiko Shimizu, Shotaro Uehara, Katsuhiro Ohyama, Haruka Nishimura, Yoichi Tanaka, Yoshiro Saito, Hiroshi Suemizu, Sayaka Yoshida and Hiroshi Yamazaki

Drug Metabolism and Disposition October 25, 2023, DMD-AR-2023-001481; DOI: https://doi.org/10.1124/dmd.123.001481

October 18, 2023

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Absorption, metabolism and excretion of ¹⁴C-emvododstat following repeat daily oral dose administration in human volunteers using a combination of microtracer radioactivity and high radioactivity doses
Jiyuan Ma, Oscar L. Laskin, Ad F. Roffel, Wouter H.J. Vaes, Bowen Tang, Jeroen Kolnaar, Kylie O'Keefe, Lee Golden and Ronald Kong

Drug Metabolism and Disposition October 18, 2023, DMD-AR-2023-001471; DOI: https://doi.org/10.1124/dmd.123.001471

October 13, 2023

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Canadian Content in the Pages of Drug Metabolism and Disposition: A Comprehensive Historical Analysis
David S. Riddick

Drug Metabolism and Disposition October 13, 2023, DMD-MR-2023-001517; DOI: https://doi.org/10.1124/dmd.123.001517

October 04, 2023

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Cytochrome P450 enzymes as drug targets in human disease
F. Peter Guengerich

Drug Metabolism and Disposition October 4, 2023, DMD-MR-2023-001431; DOI: https://doi.org/10.1124/dmd.123.001431
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Acetaminophen-Induced Hepatic Necrosis: A Reminiscence
David Jollow

Drug Metabolism and Disposition October 4, 2023, DMD-COM-2023-001278; DOI: https://doi.org/10.1124/dmd.123.001278

September 15, 2023

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Potential and Challenges in Application of Physiologically Based Pharmacokinetic Modeling in Predicting Diarrheal Disease Impact on Oral Drug Pharmacokinetics
Cindy X. Zhang and Samuel L.M. Arnold

Drug Metabolism and Disposition September 15, 2023, DMD-MR-2022-000964; DOI: https://doi.org/10.1124/dmd.122.000964

August 11, 2023

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Central mechanisms of acetaminophen hepatotoxicity: mitochondrial dysfunction by protein adducts and oxidant stress
Hartmut Jaeschke and Anup Ramachandran

Drug Metabolism and Disposition August 11, 2023, DMD-MR-2023-001279; DOI: https://doi.org/10.1124/dmd.123.001279

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