Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

January 20, 2021

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Function and Expression of Bile Salt Export Pump in Suspension Human Hepatocytes
Paresh P. Chothe, Rachel Pemberton and Niresh Hariparsad

Drug Metabolism and Disposition January 20, 2021, DMD-AR-2020-000057; DOI: https://doi.org/10.1124/dmd.120.000057

January 14, 2021

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Role of human AADAC on hydrolysis of eslicarbazepine acetate and effects of AADAC genetic polymorphisms on hydrolase activity
Keiya Hirosawa, Tatsuki Fukami, Kiyomichi Tashiro, Yoshiyuki Sakai, Fumiya Kisui, Masataka Nakano and Miki Nakajima

Drug Metabolism and Disposition January 14, 2021, DMD-AR-2020-000295; DOI: https://doi.org/10.1124/dmd.120.000295
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In vitro evidence of potential interactions between CYP2C8 and candesartan acyl-β-D-glucuronide in the liver
Yurie Katsube, Masayuki Tsujimoto, Hiroyoshi Koide, Daiki Hira, Yoshito Ikeda, Tetsuya Minegaki, Shin-ya Morita, Tomohiro Terada and Kohshi Nishiguchi

Drug Metabolism and Disposition January 14, 2021, DMD-AR-2020-000126; DOI: https://doi.org/10.1124/dmd.120.000126

December 31, 2020

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In vivo gene expression profile of human intestinal epithelial cells: from the viewpoint of drug metabolism and pharmacokinetics
Kazuo Takayama, Kohei Ito, Akiko Matsui, Tomoki Yamashita, Kentaro Kawakami, Daisuke Hirayama, Wataru Kishimoto, Hiroshi Nakase and Hiroyuki Mizuguchi

Drug Metabolism and Disposition December 31, 2020, DMD-AR-2020-000283; DOI: https://doi.org/10.1124/dmd.120.000283
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Functional characterization of 40 CYP3A4 variants by assessing midazolam 1′-hydroxylation and testosterone 6β-hydroxylation
Masaki Kumondai, Evelyn Marie Gutiérrez Rico, Eiji Hishinuma, Akiko Ueda, Sakae Saito, Daisuke Saigusa, Shu Tadaka, Kengo Kinoshita, Tomoki Nakayoshi, Akifumi Oda, Ai Abe, Masamitsu Maekawa, Nariyasu Mano, Noriyasu Hirasawa and Masahiro Hiratsuka

Drug Metabolism and Disposition December 31, 2020, DMD-AR-2020-000261; DOI: https://doi.org/10.1124/dmd.120.000261

December 29, 2020

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Tryptophan-75 is a Low Energy Channel Gating Residue that Facilitates Substrate Egress/Access in Cytochrome P450 2D6
Kevin D. McCarty, Samuel A. Ratliff, Kyle A. Furge and Laura Lowe Furge

Drug Metabolism and Disposition December 29, 2020, DMD-AR-2020-000274; DOI: https://doi.org/10.1124/dmd.120.000274
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The Hypoglycemic Effect of Berberine and Berberrubine Involves Modulation of Intestinal FXR Signaling Pathway and Inhibition of Hepatic Gluconeogenesis
Runbin Sun, Bo Kong, Na Yang, Bei Cao, Dong Feng, Xiaoyi Yu, Chun Ge, Siqi Feng, Fei Fei, Jingqiu Huang, Zhenyao Lu, Yuan Xie, Chung S. Yang, Grace L. Guo, Guangji Wang and Jiye Aa

Drug Metabolism and Disposition December 29, 2020, DMD-AR-2020-000215; DOI: https://doi.org/10.1124/dmd.120.000215
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Detoxication vs. Bioactivation Pathways of Lapatinib In Vitro: UGT1A1 Catalyzes the Hepatic Glucuronidation of Debenzylated Lapatinib
Dasean T. Nardone-White, Jennifer E. Bissada, Arsany A. Abouda and Klarissa D. Jackson

Drug Metabolism and Disposition December 29, 2020, DMD-AR-2020-000236; DOI: https://doi.org/10.1124/dmd.120.000236
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Evaluation of the Utility of PXB Chimeric Mice for Predicting Human Liver Partitioning of Hepatic Organic Anion-Transporting Peptide Substrates
Bo Feng, Rachel Pemberton, Wojciech Dworakowski, Zhengqi Ye, Craig Zetterberg, Guanyu Wang, Yoshio Morikawa and Sanjeev Kumar

Drug Metabolism and Disposition December 29, 2020, DMD-AR-2020-000276; DOI: https://doi.org/10.1124/dmd.120.000276

December 21, 2020

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Evaluation of tissue stem cell derived human intestinal organoids, a physiologically relevant model to evaluate cytochrome P450 induction in gut
David M. Stresser, Jun Sun and Sarah S. Wilson

Drug Metabolism and Disposition December 21, 2020, DMD-AR-2020-000281; DOI: https://doi.org/10.1124/dmd.120.000281

December 18, 2020

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Impact of plasma protein binding in drug clearance prediction: a database analysis of published studies and implications for in vitro in vivo extrapolation
Laura Jane Francis, Brian Houston and David Hallifax

Drug Metabolism and Disposition December 18, 2020, DMD-AR-2020-000294; DOI: https://doi.org/10.1124/dmd.120.000294
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Prediction of transporter-mediated drug-drug interactions and phenotyping of hepatobiliary transporters involved in the clearance of E7766, a novel macrocycle-bridged dinucleotide
Rongrong Jiang, Andrew Hart, Laurette Burgess, Dae-Shik Kim, Weidong George Lai and Vaishali Dixit

Drug Metabolism and Disposition December 18, 2020, DMD-AR-2020-000125; DOI: https://doi.org/10.1124/dmd.120.000125
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Aldehyde Oxidase Contributes to all-trans-Retinoic Acid Biosynthesis in Human Liver
Guo Zhong, Chris J. Seaman, Erickson M. Paragas, Huanqing Xi, Karla-Luise Herpoldt, Neil King, Jeffrey P. Jones and Nina Isoherranen

Drug Metabolism and Disposition December 18, 2020, DMD-AR-2020-000296; DOI: https://doi.org/10.1124/dmd.120.000296

December 03, 2020

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In vitro metabolism of slowly cleared GPR139 agonist TAK-041 using rat, dog, monkey and human hepatocyte models (HepatoPac): correlation with in vivo metabolism
Amin Kamel, Stephen Bowlin, Natalie Hosea, Dimitrios Arkilo and Antonio Laurenza

Drug Metabolism and Disposition December 3, 2020, DMD-AR-2020-000246; DOI: https://doi.org/10.1124/dmd.120.000246

December 01, 2020

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Impact of direction of transport on the evaluation of inhibition potencies of multidrug and toxin extrusion protein 1 (MATE1) inhibitors
Asami Saito, Naoki Ishiguro, Masahito Takatani, Bojan Bister and Hiroyuki Kusuhara

Drug Metabolism and Disposition December 1, 2020, DMD-AR-2020-000136; DOI: https://doi.org/10.1124/dmd.120.000136
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Use of Intravenous Infusion Study Design to Simultaneously Determine Brain Penetration and Systemic Pharmacokinetic Parameters in Rats
Keumhan Noh, Alicia Pietrasiewicz, Xingrong Liu and Cong Wei

Drug Metabolism and Disposition December 1, 2020, DMD-AR-2020-000242; DOI: https://doi.org/10.1124/dmd.120.000242

November 25, 2020

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Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics
Mary Alexandra Schleiff, Noah R. Flynn, Sasin Payakachat, Benjamin Mark Schleiff, Anna O. Pinson, Dennis W. Province, S. Joshua Swamidass, Gunnar Boysen and Grover P. Miller

Drug Metabolism and Disposition November 25, 2020, DMD-AR-2020-000254; DOI: https://doi.org/10.1124/dmd.120.000254
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Predicting Volume of Distribution in Humans: Performance of in silico Methods for A Large Set of Structurally Diverse Clinical Compounds
Neha Murad, Kishore K. Pasikanti, Benjamin D. Madej, Amanda Minnich, Juliet M. McComas, Sabrinia Crouch, Joseph W. Polli and Andrew D. Weber

Drug Metabolism and Disposition November 25, 2020, DMD-AR-2020-000202; DOI: https://doi.org/10.1124/dmd.120.000202

October 13, 2020

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Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach
Vineet Kumar, Mengyue Yin, Kazuya Ishida, Laurent Salphati, Cornelis E.C.A. Hop, Christopher Rowbottom, Guangqing Xiao, Yurong Lai, Anita Mathias, Xiaoyan Chu, W. Griffith Humphreys, Mingxiang Liao, Zsuzsanna Nerada, Nóra Szilvásy, Scott Heyward and Jashvant D. Unadkat

Drug Metabolism and Disposition October 13, 2020, DMD-AR-2020-000204; DOI: https://doi.org/10.1124/dmd.120.000204

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