Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

November 17, 2021

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Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19 and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model
Diane Ramsden, Elke S. Perloff, Andrea Whitcher-Johnstone, Thuy Ho, Reena Patel, Kirk D. Kozminski, Cody L. Fullenwider and J George Zhang

Drug Metabolism and Disposition November 17, 2021, DMD-AR-2021-000718; DOI: https://doi.org/10.1124/dmd.121.000718

November 16, 2021

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Metabolism of a selective serotonin and norepinephrine reuptake inhibitor duloxetine in liver microsomes and mice
Xuan Qin, John M. Hakenjos, Kevin R. MacKenzie, Mercedes Barzi, Hemantkumar Chavan, Pranavanand Nyshadham, Jin Wang, Sung Yun Jung, Joie Z. Guner, Si Chen, Lei Guo, Partha Krishnamurthy, Karl-Dimiter Bissig, Stephen Palmer, Martin M. Matzuk and Feng Li

Drug Metabolism and Disposition November 16, 2021, DMD-AR-2021-000633; DOI: https://doi.org/10.1124/dmd.121.000633

November 10, 2021

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Environmental Chemical Contribution to the Modulation of Bile Acid Homeostasis and Farnesoid X Receptor Signaling
Rulaiha Elizabeth Taylor, Anisha Bhattacharya and Grace L. Guo

Drug Metabolism and Disposition November 10, 2021, DMD-MR-2021-000388; DOI: https://doi.org/10.1124/dmd.121.000388
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The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
Erin C Berthold, Shyam H Kamble, Kanumuri S Raju, Michelle A Kuntz, Alexandria S Senetra, Marco Mottinelli, Francisco León, Luis F Restrepo, Avi Patel, Nicholas P Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy

Drug Metabolism and Disposition November 10, 2021, DMD-AR-2021-000640; DOI: https://doi.org/10.1124/dmd.121.000640

November 08, 2021

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Evaluation of ADMET Predictor^TM in early discovery DMPK project work
Anna-Karin Sohlenius-Sternbeck and Ylva Terelius

Drug Metabolism and Disposition November 8, 2021, DMD-AR-2021-000552; DOI: https://doi.org/10.1124/dmd.121.000552
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Permeabilized cryopreserved human hepatocytes as an exogenous metabolic system in a novelmetabolism-dependent cytotoxicity assay (MDCA) for the evaluation of metabolic activation anddetoxification of drugs associated with drug induced liver injuries: Results with acetaminophen,amiodarone, cyclophosphamide, ketoconazole, nefazodone, and troglitazone
Hong Wei and Albert P. Li

Drug Metabolism and Disposition November 8, 2021, DMD-AR-2021-000645; DOI: https://doi.org/10.1124/dmd.121.000645

November 05, 2021

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In defense of current concepts and applications of clearance in drug development and therapeutics
Malcolm Rowland, Michael S. Roberts and K. Sandy Pang

Drug Metabolism and Disposition November 5, 2021, DMD-AR-2021-000637; DOI: https://doi.org/10.1124/dmd.121.000637

November 02, 2021

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The impact of age and genetics on naltrexone biotransformation
Stephani L. Stancil, Whitney Nolte, Robin E. Pearce, Vincent S. Staggs and J. Steven Leeder

Drug Metabolism and Disposition November 2, 2021, DMD-AR-2021-000646; DOI: https://doi.org/10.1124/dmd.121.000646

October 25, 2021

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Intestinal UGT1A1 and protection against Irinotecan-induced toxicity in a novel UGT1A1 tissue-specific humanized mouse model.
Elvira Mennillo, Xiaojing Yang, Andre A Weber, Yoshihiro Maruo, Melanie Verreault, Olivier Barbier, Shujuan Chen and Robert H. Tukey

Drug Metabolism and Disposition October 25, 2021, DMD-AR-2021-000644; DOI: https://doi.org/10.1124/dmd.121.000644
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Overview of Current Herb-Drug Interaction Databases
Yufeng Zhang, Chung Man Ip, Yuen Sze Lai and Zhong Zuo

Drug Metabolism and Disposition October 25, 2021, DMD-MR-2021-000420; DOI: https://doi.org/10.1124/dmd.121.000420
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Transcriptional regulation of carboxylesterase 1 (CES1) in human liver: role of the nuclear receptor NR1H3 (LXRα) and its splice isoforms
Joseph M Collins, Rong Lu, Xinwen Wang, Hao-Jie Zhu and Danxin Wang

Drug Metabolism and Disposition October 25, 2021, DMD-AR-2021-000649; DOI: https://doi.org/10.1124/dmd.121.000649

October 22, 2021

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MOLECULAR REGULATION OF BILE ACID HOMEOSTASIS
Supratim Choudhuri and Curtis D. Klaassen

Drug Metabolism and Disposition October 22, 2021, DMD-MR-2021-000643; DOI: https://doi.org/10.1124/dmd.121.000643
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Ontogeny of Scaling Factors for Pediatric PBPK Modeling and Simulation: Microsomal Protein Per Gram of Liver
J. Steven Leeder, Jean C. Dinh, Andrea Gaedigk, Vincent S. Staggs, Bhagwat Prasad and Robin E. Pearce

Drug Metabolism and Disposition October 22, 2021, DMD-AR-2021-000623; DOI: https://doi.org/10.1124/dmd.121.000623

October 20, 2021

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New pharmacokinetic parameters of imaging substrates quantified from rat liver compartments
Catherine M Pastor and Kim LR Brouwer

Drug Metabolism and Disposition October 20, 2021, DMD-AR-2021-000546; DOI: https://doi.org/10.1124/dmd.121.000546
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Simultaneous evaluation of membrane permeability and UDP-glucuronosyltransferase-mediated metabolism of food-derived compounds using human induced pluripotent stem cell-derived small intestinal epithelial cells
Takashi Kitaguchi, Taisei Mizota, Mina Ito, Katsutoshi Ohno, Kazuhiro Kobayashi, Isamu Ogawa, Shimeng Qiu, Takahiro Iwao, Nobumitsu Hanioka, Mitsuru Tanaka and Tamihide Matsunaga

Drug Metabolism and Disposition October 20, 2021, DMD-AR-2021-000605; DOI: https://doi.org/10.1124/dmd.121.000605

October 14, 2021

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Simulating the Selection of Resistant Cells with Bystander Killing and Antibody Coadministration in Heterogeneous HER2 Positive Tumors
Bruna Menezes, Jennifer J. Linderman and Greg M. Thurber

Drug Metabolism and Disposition October 14, 2021, DMD-AR-2021-000503; DOI: https://doi.org/10.1124/dmd.121.000503

October 08, 2021

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Pharmacokinetics and ADME characterization of intravenous and oral [¹⁴C]-linerixibat in healthy male volunteers
Maciej J. Zamek-Gliszczynski, David Kenworthy, David A. Bershas, Mitesh Sanghvi, Adrian I. Pereira, Jennypher Mudunuru, Lee Crossman, Jill L. Pirhalla, Karl M. Thorpe, Jeremy M.T.J. Dennison, Megan M. McLaughlin, Matthew Allinder, Brandon Swift, Robin L. O'Connor-Semmes and Graeme C. Young

Drug Metabolism and Disposition October 8, 2021, DMD-AR-2021-000595; DOI: https://doi.org/10.1124/dmd.121.000595

October 07, 2021

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Pharmacokinetic Drug-Drug Interactions with Drugs Approved by the U.S. Food and Drug Administration in 2020: Mechanistic Understanding and Clinical Recommendations
Jingjing Yu, Yan Wang and Isabelle Ragueneau-Majlessi

Drug Metabolism and Disposition October 7, 2021, DMD-MR-2021-000401; DOI: https://doi.org/10.1124/dmd.121.000401
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Addressing today's ADME challenges in the translation of in vitro absorption, distribution, metabolism and excretion characteristics to human: A case study of the SMN2 mRNA splicing modifier risdiplam
Stephen Fowler, Andreas Brink, Yumi Cleary, Andreas Guenther, Katja Heinig, Christophe Husser, Heidemarie Kletzl, Nicole A. Kratochwil, Lutz Mueller, Mark Savage, Cordula Stillhart, Dietrich W. Tuerck, Mohammed Ullah, Kenichi Umehara and Agnès Poirier

Drug Metabolism and Disposition October 7, 2021, DMD-MR-2021-000563; DOI: https://doi.org/10.1124/dmd.121.000563

October 04, 2021

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Cytochrome P450 Binding and Bioactivation of Tumor-targeted Duocarmycin Agents
Aaron G. Bart, Goreti Morais, Venu R. Vangala, Paul M. Loadman, Klaus Pors and Emily E. Scott

Drug Metabolism and Disposition October 4, 2021, DMD-AR-2021-000642; DOI: https://doi.org/10.1124/dmd.121.000642

September 16, 2021

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Exogenous Drug Disposition as a Diagnostic Biomarker Strategy for Non-Alcoholic Steatohepatitis
Solène MARIE, David K.K. TRIPP and Nathan J. CHERRINGTON

Drug Metabolism and Disposition September 16, 2021, DMD-MR-2021-000413; DOI: https://doi.org/10.1124/dmd.121.000413

September 09, 2021

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Complex Cytochrome P450 kinetics due to multisubstrate binding and sequential metabolism. Part 1. Theoretical considerations.
Zeyuan Wang, Erickson M. Paragas, Swati Nagar and Ken Korzekwa

Drug Metabolism and Disposition September 9, 2021, DMD-AR-2021-000553; DOI: https://doi.org/10.1124/dmd.121.000553
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Complex Cytochrome P450 kinetics due to multisubstrate binding and sequential metabolism. Part 2. Modeling of experimental data
Erickson M. Paragas, Zeyuan Wang, Ken Korzekwa and Swati Nagar

Drug Metabolism and Disposition September 9, 2021, DMD-AR-2021-000554; DOI: https://doi.org/10.1124/dmd.121.000554

September 07, 2021

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Cannabinoid metabolites as inhibitors of major hepatic CYP450 enzymes, with implications for cannabis-drug interactions
Shamema Nasrin, Christy J.W. Watson, Yadira X Perez-Paramo and Philip Lazarus

Drug Metabolism and Disposition September 7, 2021, DMD-AR-2021-000442; DOI: https://doi.org/10.1124/dmd.121.000442
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Inhibition of UDP-glucuronosyltransferase enzymes by major cannabinoids and their metabolites
Shamema Nasrin, Christy J.W. Watson, Keti Bardhi, Gabriela Fort, Gang Chen and Philip Lazarus

Drug Metabolism and Disposition September 7, 2021, DMD-AR-2021-000530; DOI: https://doi.org/10.1124/dmd.121.000530

August 23, 2021

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Feature, Function, and Information of Drug Transporter Related Databases
Jiayi Yin, Fengcheng Li, Zhaorong Li, Lushan Yu, Feng Zhu and Su Zeng

Drug Metabolism and Disposition August 23, 2021, DMD-MR-2021-000419; DOI: https://doi.org/10.1124/dmd.121.000419

August 04, 2021

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Augmented clearance of nivolumab is associated with renal functions in chronic renal disease model rats
Kazuaki Taguchi, Yukitaka Hayashi, Mayu Ohuchi, Hotaka Yamada, Shigehiro Yagishita, Yuki Enoki, Kazuaki Matsumoto and Akinobu Hamada

Drug Metabolism and Disposition August 4, 2021, DMD-AR-2021-000520; DOI: https://doi.org/10.1124/dmd.121.000520
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Alterations of cytochrome P450-mediated drug metabolism during liver repair and regeneration after acetaminophen-induced liver injury in mice
Yifan Bao, Mi Phan, Junjie Zhu, Xiaochao Ma, Jose E. Manautou and Xiao-bo Zhong

Drug Metabolism and Disposition August 4, 2021, DMD-AR-2021-000459; DOI: https://doi.org/10.1124/dmd.121.000459

June 29, 2021

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The Nonclinical Disposition and PK/PD Properties of GalNAc-conjugated siRNA Are Highly Predictable and Build Confidence in Translation to Man
Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher R. Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Christopher Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu

Drug Metabolism and Disposition June 29, 2021, DMD-MR-2021-000428; DOI: https://doi.org/10.1124/dmd.121.000428

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