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Drug Metabolism & Disposition

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Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

May 11, 2022

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    Isotretinoin and its metabolites alter mRNA of multiple enzyme and transporter genes in vitro but downregulation of OATP1B1 does not translate to the clinic
    Aprajita S. Yadav, Faith Stevison, Mika Kosaka, Susan Wong, Jane R. Kenny, John K. Amory and Nina Isoherranen
    Drug Metabolism and Disposition May 11, 2022, DMD-AR-2022-000882; DOI: https://doi.org/10.1124/dmd.122.000882
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    Sinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance Model
    Philip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W Yucha, Swapan K. Chowdhury and Paresh P. Chothe
    Drug Metabolism and Disposition May 11, 2022, DMD-AR-2022-000836; DOI: https://doi.org/10.1124/dmd.122.000836
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    Target-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fc-fusion Proteins at Pharmacologically Active Doses
    Zheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois D. Lehman-McKeeman, Paul Morin and Robert F Graziano
    Drug Metabolism and Disposition May 11, 2022, DMD-AR-2021-000799; DOI: https://doi.org/10.1124/dmd.121.000799

May 05, 2022

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    Metabolic Activation of the Acrylamide Michael Acceptor Warhead in Futibatinib to an Epoxide Intermediate Engenders Covalent Inactivation of Cytochrome P450 3A
    Lloyd Wei Tat Tang, Jiaxin Fu, Siew Kwan Koh, Guoyi Wu, Lei Zhou and Eric Chun Yong Chan
    Drug Metabolism and Disposition May 5, 2022, DMD-AR-2022-000895; DOI: https://doi.org/10.1124/dmd.122.000895
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    Prediction of Carboxylesterase 1 (CES1)-mediated In Vivo Drug Interaction between Methylphenidate and Cannabinoids using Static and Physiologically Based Pharmacokinetic Models
    Yuli Qian and John S. Markowitz
    Drug Metabolism and Disposition May 5, 2022, DMD-AR-2021-000823; DOI: https://doi.org/10.1124/dmd.121.000823
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    Impact of inflammation and infection on the expression of amino acid transporters in the placenta: A minireview
    Eliza R McColl, Milena Hurtarte and Micheline Piquette-Miller
    Drug Metabolism and Disposition May 5, 2022, DMD-MR-2021-000703; DOI: https://doi.org/10.1124/dmd.121.000703
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    Stereoselective metabolism of bupropion to active metabolites in cellular fractions of human liver and intestine.
    Nadia O. Bamfo, Jessica Bo Li Lu and Zeruesenay Desta
    Drug Metabolism and Disposition May 5, 2022, DMD-AR-2022-000867; DOI: https://doi.org/10.1124/dmd.122.000867

May 03, 2022

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    Perspective of the Induction of Liver Microsomal P450s by Chemical Compounds
    Tsuneo Omura
    Drug Metabolism and Disposition May 3, 2022, DMD-COM-2022-000891; DOI: https://doi.org/10.1124/dmd.122.000891
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    Metabolism and Disposition of [14C]Pevonedistat, a First-In-Class NEDD8‑Activating Enzyme Inhibitor, After Intravenous Infusion to Patients With Advanced Solid Tumors
    Jayaprakasam Bolleddula, Hao Chen, Lawrence Cohen, Xiaofei Zhou, Sandeepraj Pusalkar, Allison Berger, Farhad Sedarati, Karthik Venkatakrishnan and Swapan K. Chowdhury
    Drug Metabolism and Disposition May 3, 2022, DMD-AR-2022-000842; DOI: https://doi.org/10.1124/dmd.122.000842
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    Regulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-β/Activin Receptor-Like Kinase 1 (TGF-β/ALK1) Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors (i.e., Statins)
    Robert D. Betterton, Wazir Abdullahi, Erica I. Williams, Jeffrey L. Lochhead, Hrvoje Brzica, Joshua A Stanton, Elizabeth Reddell, Chidinma Ogbonnaya, Thomas P Davis and Patrick T. Ronaldson
    Drug Metabolism and Disposition May 3, 2022, DMD-AR-2021-000781; DOI: https://doi.org/10.1124/dmd.121.000781
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    Understanding Inter-individual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-limited Multi-compartment Liver Model in a Population Based PBPK Framework
    Mian Zhang, Ciarán Fisher, Iain Gardner, Xian Pan, Peter Kilford, Frederic Bois and Masoud Jamei
    Drug Metabolism and Disposition May 3, 2022, DMD-AR-2021-000818; DOI: https://doi.org/10.1124/dmd.121.000818

April 29, 2022

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    The hydroxylation position rather than chirality determines how efavirenz metabolites activate CYP46A1 in vitro
    Natalia Mast, Anna Fotinich and Irina A. Pikuleva
    Drug Metabolism and Disposition April 29, 2022, DMD-AR-2022-000874; DOI: https://doi.org/10.1124/dmd.122.000874
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    Selection of an optimal in vitro model to assess P-gp inhibition: comparison of vesicular and bi-directional transcellular transport inhibition assays
    Jocelyn Yabut, Robert Houle, Shubing Wang, Andy Liaw, Ravi Katwaru, Hannah Collier, Lucinda Hittle and Xiaoyan Chu
    Drug Metabolism and Disposition April 29, 2022, DMD-AR-2021-000807; DOI: https://doi.org/10.1124/dmd.121.000807

April 03, 2022

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    Characterizing and Quantifying Extrahepatic Metabolism of (-)-∆9-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, 11-OH-THC
    Aditya R. Kumar, Gabriela I. Patilea-Vrana, Olena Anoshchenko and Jashvant D. Unadkat
    Drug Metabolism and Disposition April 3, 2022, DMD-AR-2022-000868; DOI: https://doi.org/10.1124/dmd.122.000868

March 29, 2022

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    Reevaluate In Vitro CYP3A Index Reactions of Benzodiazepines and Steroids between Humans and Dogs
    Qingliang Wu, Yiting Hu, CuiTong Wang, Wei Wei, Lanlan Gui, Wu-shuang Zeng, Changxiao Liu, Wei Jia, Jia Miao and Ke Lan
    Drug Metabolism and Disposition March 29, 2022, DMD-AR-2022-000864; DOI: https://doi.org/10.1124/dmd.122.000864
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    Is The Protein-Mediated Uptake Of Drugs By OATPs A Real Phenomenon Or An Artifact?
    Mengyue Yin, Flavia Storelli and Jashvant D. Unadkat
    Drug Metabolism and Disposition March 29, 2022, DMD-AR-2022-000849; DOI: https://doi.org/10.1124/dmd.122.000849

March 26, 2022

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    Predicting impact of food and feeding time on oral absorption of drugs with a novel rat continuous intestinal absorption model
    Casey Radice, Ken Korzekwa and Swati Nagar
    Drug Metabolism and Disposition March 26, 2022, DMD-AR-2022-000831; DOI: https://doi.org/10.1124/dmd.122.000831

March 20, 2022

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    Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier
    Raymond K. Hau, Robert R Klein, Stephen H. Wright and Nathan J Cherrington
    Drug Metabolism and Disposition March 20, 2022, DMD-AR-2021-000748; DOI: https://doi.org/10.1124/dmd.121.000748
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    Label-Free but Still Constrained: Assessment of Global Proteomic Strategies for the Quantification of Hepatic Enzymes and Transporters
    Jill Barber, Zubida M. Al-Majdoub, Narciso Couto, Areti-Maria Vasilogianni, Annika Tillmann, Sarah Alrubia, Amin Rostami-Hodjegan and Brahim Achour
    Drug Metabolism and Disposition March 20, 2022, DMD-AR-2021-000780; DOI: https://doi.org/10.1124/dmd.121.000780

March 19, 2022

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    A Cross Company Perspective on the Assessment of Therapeutic Protein Biotransformation
    Markus Walles, Michael J Berna, Wenying Jian, Simon Hauri, Shawna Hengel, Lloyd King, John C Tran, Cong Wei, Keyang Xu and Xiaochun Zhu
    Drug Metabolism and Disposition March 19, 2022, DMD-MR-2021-000462; DOI: https://doi.org/10.1124/dmd.121.000462

March 02, 2022

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    Clinical relevance of the constitutive androstane receptor
    Sydney Stern, Ritika Kurian and Hongbing Wang
    Drug Metabolism and Disposition March 2, 2022, DMD-MR-2021-000483; DOI: https://doi.org/10.1124/dmd.121.000483

February 27, 2022

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    Adverse Drug Reactions and Toxicity of the FDA-approved Antisense Oligonucleotide Drugs
    Feryal Alhamadani, Kristy Zhang, Rajvi Parikh, Hangyu Wu, Theodore P Rasmussen, Raman Bahal, Xiao-bo Zhong and Jose E. Manautou
    Drug Metabolism and Disposition February 27, 2022, DMD-MR-2021-000418; DOI: https://doi.org/10.1124/dmd.121.000418
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    Absorption, distribution, metabolism, and excretion of FDA-approved antisense oligonucleotide drugs
    Julia M Migliorati, Sunna Liu, Anna Liu, Anagha Gogate, Sreenidhi Nair, Raman Bahal, Theodore P Rasmussen, Jose E. Manautou and Xiao-bo Zhong
    Drug Metabolism and Disposition February 27, 2022, DMD-MR-2021-000417; DOI: https://doi.org/10.1124/dmd.121.000417

February 23, 2022

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    Mathematical models to characterize the absorption, distribution, metabolism, and excretion (ADME) of protein therapeutics
    Shufang Liu and Dhaval K Shah
    Drug Metabolism and Disposition February 23, 2022, DMD-MR-2021-000460; DOI: https://doi.org/10.1124/dmd.121.000460
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    CYP2C19 plays a major role in the hepatic N-oxidation of cotinine
    Yadira X Perez-Paramo, Christy J.W. Watson, Gang Chen and Philip Lazarus
    Drug Metabolism and Disposition February 23, 2022, DMD-AR-2021-000624; DOI: https://doi.org/10.1124/dmd.121.000624

February 22, 2022

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    From Steroid and Drug Metabolism to Glycobiology, Using Sulfotransferase Structures to Understand and Tailor Function
    Lars C Pedersen, MyeongJin Yi, Lee G. Pedersen and Andrea M Kaminski
    Drug Metabolism and Disposition February 22, 2022, DMD-MR-2021-000478; DOI: https://doi.org/10.1124/dmd.121.000478
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    Clinical Applications and the Roles of Transporters in Disposition, Tumor Targeting, and Tissue Toxicity of meta-Iodobenzylguanidine (mIBG)
    Antonio J Lopez Quiñones, Leticia Salvador Vieira and Joanne Wang
    Drug Metabolism and Disposition February 22, 2022, DMD-MR-2021-000707; DOI: https://doi.org/10.1124/dmd.121.000707

February 19, 2022

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    Distinct roles of the sister nuclear receptors PXR and CAR in liver cancer development
    Kouichi Yoshinari and Ryota Shizu
    Drug Metabolism and Disposition February 19, 2022, DMD-MR-2021-000481; DOI: https://doi.org/10.1124/dmd.121.000481
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    Searching for CAR modulators
    Paavo Honkakoski
    Drug Metabolism and Disposition February 19, 2022, DMD-MR-2021-000482; DOI: https://doi.org/10.1124/dmd.121.000482

February 12, 2022

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    Amino Acid Solute Carrier Transporters in Inflammation and Autoimmunity
    Linlin Sheng, Qi Luo and Ligong Chen
    Drug Metabolism and Disposition February 12, 2022, DMD-AR-2021-000705; DOI: https://doi.org/10.1124/dmd.121.000705

February 11, 2022

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    Absorption, Distribution, Metabolism, and Excretion (ADME) of Therapeutic Proteins: Current Industry Practices and Future Perspectives
    Jayaprakasam Bolleddula, Kevin Brady, Gerard Bruin, Anthony J Lee, Jennifer A Martin, Markus Walles, Keyang Xu, Tong-Yuan Yang, Xiaochun Zhu and Hongbin Yu
    Drug Metabolism and Disposition February 11, 2022, DMD-MR-2021-000461; DOI: https://doi.org/10.1124/dmd.121.000461
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    Characterizing the pharmacokinetics and biodistribution of therapeutic proteins: an industry white paper
    Kathryn Ball, Gerard Bruin, Enrique Escandon, Christoph Funk, Joao NS Pereira, Tong-Yuan Yang and Hongbin Yu
    Drug Metabolism and Disposition February 11, 2022, DMD-MR-2021-000463; DOI: https://doi.org/10.1124/dmd.121.000463

January 22, 2022

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    The in vivo pharmacokinetics of block copolymers containing polyethylene glycol used in nanocarrier drug delivery systems
    Lei Yin, Yiling Pang, Lin Shan and Jingkai Gu
    Drug Metabolism and Disposition January 22, 2022, DMD-MR-2021-000568; DOI: https://doi.org/10.1124/dmd.121.000568

January 06, 2022

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    Regulation of Placental Efflux Transporters During Pregnancy Complications
    Danielle Kozlosky, Emily Barrett and Lauren M. Aleksunes
    Drug Metabolism and Disposition January 6, 2022, DMD-MR-2021-000449; DOI: https://doi.org/10.1124/dmd.121.000449

December 17, 2021

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    Attenuated Ochratoxin A Transporter Expression in a Mouse Model of Nonalcoholic Steatohepatitis Protects against Proximal Convoluted Tubule Toxicity.
    Joseph L. Jilek, Kayla L. FROST, Solène MARIE, Cassandra M. MYERS, Michael GOEDKEN, Stephen H. Wright and Nathan J. CHERRINGTON
    Drug Metabolism and Disposition December 17, 2021, DMD-MR-2021-000451; DOI: https://doi.org/10.1124/dmd.121.000451
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    Emerging Roles of the Human Solute Carrier 22 Family
    Sook Wah Yee and Kathleen M. Giacomini
    Drug Metabolism and Disposition December 17, 2021, DMD-MR-2021-000702; DOI: https://doi.org/10.1124/dmd.121.000702

December 14, 2021

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    Regulation of transporters by perfluorinated carboxylic acids in HepaRG cells
    Joe Jongpyo Lim, Youjun Suh, Elaine M Faustman and Julia Yue Cui
    Drug Metabolism and Disposition December 14, 2021, DMD-AR-2021-000477; DOI: https://doi.org/10.1124/dmd.121.000477

December 03, 2021

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    Mechanistic study on the species differences in excretion pathway of HR011303 in human and rats
    Zitao Guo, Mengling Liu, Jian Meng, Yaru Xue, Qi Huang, Yuandong Zheng, Yali Wu, Zhendong Chen, Jinghua Yu, Dafang Zhong, Guangze Li, Xiaoyan Chen and Xingxing Diao
    Drug Metabolism and Disposition December 3, 2021, DMD-AR-2021-000582; DOI: https://doi.org/10.1124/dmd.121.000582
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    Pharmacokinetics, Mass Balance, and Metabolism of the Novel URAT1 Inhibitor [14C]HR011303 in Humans: Metabolism is Mediated Predominantly by UDP-glucuronosyltransferase
    Yuandong Zheng, Hua Zhang, Mengling Liu, Guangze Li, Sheng Ma, Zhe Zhang, Hongda Lin, Yan Zhan, Zhendong Chen, Dafang Zhong, Liyan Miao and Xingxing Diao
    Drug Metabolism and Disposition December 3, 2021, DMD-AR-2021-000581; DOI: https://doi.org/10.1124/dmd.121.000581

August 04, 2021

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    Augmented clearance of nivolumab is associated with renal functions in chronic renal disease model rats
    Kazuaki Taguchi, Yukitaka Hayashi, Mayu Ohuchi, Hotaka Yamada, Shigehiro Yagishita, Yuki Enoki, Kazuaki Matsumoto and Akinobu Hamada
    Drug Metabolism and Disposition August 4, 2021, DMD-AR-2021-000520; DOI: https://doi.org/10.1124/dmd.121.000520

June 29, 2021

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    The Nonclinical Disposition and PK/PD Properties of GalNAc-conjugated siRNA Are Highly Predictable and Build Confidence in Translation to Man
    Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher R. Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Christopher Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu
    Drug Metabolism and Disposition June 29, 2021, DMD-MR-2021-000428; DOI: https://doi.org/10.1124/dmd.121.000428

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