Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

May 11, 2022

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Isotretinoin and its metabolites alter mRNA of multiple enzyme and transporter genes in vitro but downregulation of OATP1B1 does not translate to the clinic
Aprajita S. Yadav, Faith Stevison, Mika Kosaka, Susan Wong, Jane R. Kenny, John K. Amory and Nina Isoherranen

Drug Metabolism and Disposition May 11, 2022, DMD-AR-2022-000882; DOI: https://doi.org/10.1124/dmd.122.000882
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Sinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance Model
Philip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W Yucha, Swapan K. Chowdhury and Paresh P. Chothe

Drug Metabolism and Disposition May 11, 2022, DMD-AR-2022-000836; DOI: https://doi.org/10.1124/dmd.122.000836
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Target-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fc-fusion Proteins at Pharmacologically Active Doses
Zheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois D. Lehman-McKeeman, Paul Morin and Robert F Graziano

Drug Metabolism and Disposition May 11, 2022, DMD-AR-2021-000799; DOI: https://doi.org/10.1124/dmd.121.000799

May 05, 2022

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Metabolic Activation of the Acrylamide Michael Acceptor Warhead in Futibatinib to an Epoxide Intermediate Engenders Covalent Inactivation of Cytochrome P450 3A
Lloyd Wei Tat Tang, Jiaxin Fu, Siew Kwan Koh, Guoyi Wu, Lei Zhou and Eric Chun Yong Chan

Drug Metabolism and Disposition May 5, 2022, DMD-AR-2022-000895; DOI: https://doi.org/10.1124/dmd.122.000895
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Prediction of Carboxylesterase 1 (CES1)-mediated In Vivo Drug Interaction between Methylphenidate and Cannabinoids using Static and Physiologically Based Pharmacokinetic Models
Yuli Qian and John S. Markowitz

Drug Metabolism and Disposition May 5, 2022, DMD-AR-2021-000823; DOI: https://doi.org/10.1124/dmd.121.000823
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Impact of inflammation and infection on the expression of amino acid transporters in the placenta: A minireview
Eliza R McColl, Milena Hurtarte and Micheline Piquette-Miller

Drug Metabolism and Disposition May 5, 2022, DMD-MR-2021-000703; DOI: https://doi.org/10.1124/dmd.121.000703
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Stereoselective metabolism of bupropion to active metabolites in cellular fractions of human liver and intestine.
Nadia O. Bamfo, Jessica Bo Li Lu and Zeruesenay Desta

Drug Metabolism and Disposition May 5, 2022, DMD-AR-2022-000867; DOI: https://doi.org/10.1124/dmd.122.000867

May 03, 2022

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Perspective of the Induction of Liver Microsomal P450s by Chemical Compounds
Tsuneo Omura

Drug Metabolism and Disposition May 3, 2022, DMD-COM-2022-000891; DOI: https://doi.org/10.1124/dmd.122.000891
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Metabolism and Disposition of [¹⁴C]Pevonedistat, a First-In-Class NEDD8‑Activating Enzyme Inhibitor, After Intravenous Infusion to Patients With Advanced Solid Tumors
Jayaprakasam Bolleddula, Hao Chen, Lawrence Cohen, Xiaofei Zhou, Sandeepraj Pusalkar, Allison Berger, Farhad Sedarati, Karthik Venkatakrishnan and Swapan K. Chowdhury

Drug Metabolism and Disposition May 3, 2022, DMD-AR-2022-000842; DOI: https://doi.org/10.1124/dmd.122.000842
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Regulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-β/Activin Receptor-Like Kinase 1 (TGF-β/ALK1) Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors (i.e., Statins)
Robert D. Betterton, Wazir Abdullahi, Erica I. Williams, Jeffrey L. Lochhead, Hrvoje Brzica, Joshua A Stanton, Elizabeth Reddell, Chidinma Ogbonnaya, Thomas P Davis and Patrick T. Ronaldson

Drug Metabolism and Disposition May 3, 2022, DMD-AR-2021-000781; DOI: https://doi.org/10.1124/dmd.121.000781
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Understanding Inter-individual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-limited Multi-compartment Liver Model in a Population Based PBPK Framework
Mian Zhang, Ciarán Fisher, Iain Gardner, Xian Pan, Peter Kilford, Frederic Bois and Masoud Jamei

Drug Metabolism and Disposition May 3, 2022, DMD-AR-2021-000818; DOI: https://doi.org/10.1124/dmd.121.000818

April 29, 2022

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The hydroxylation position rather than chirality determines how efavirenz metabolites activate CYP46A1 in vitro
Natalia Mast, Anna Fotinich and Irina A. Pikuleva

Drug Metabolism and Disposition April 29, 2022, DMD-AR-2022-000874; DOI: https://doi.org/10.1124/dmd.122.000874
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Selection of an optimal in vitro model to assess P-gp inhibition: comparison of vesicular and bi-directional transcellular transport inhibition assays
Jocelyn Yabut, Robert Houle, Shubing Wang, Andy Liaw, Ravi Katwaru, Hannah Collier, Lucinda Hittle and Xiaoyan Chu

Drug Metabolism and Disposition April 29, 2022, DMD-AR-2021-000807; DOI: https://doi.org/10.1124/dmd.121.000807

April 03, 2022

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Characterizing and Quantifying Extrahepatic Metabolism of (-)-∆⁹-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, 11-OH-THC
Aditya R. Kumar, Gabriela I. Patilea-Vrana, Olena Anoshchenko and Jashvant D. Unadkat

Drug Metabolism and Disposition April 3, 2022, DMD-AR-2022-000868; DOI: https://doi.org/10.1124/dmd.122.000868

March 29, 2022

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Reevaluate In Vitro CYP3A Index Reactions of Benzodiazepines and Steroids between Humans and Dogs
Qingliang Wu, Yiting Hu, CuiTong Wang, Wei Wei, Lanlan Gui, Wu-shuang Zeng, Changxiao Liu, Wei Jia, Jia Miao and Ke Lan

Drug Metabolism and Disposition March 29, 2022, DMD-AR-2022-000864; DOI: https://doi.org/10.1124/dmd.122.000864
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Is The Protein-Mediated Uptake Of Drugs By OATPs A Real Phenomenon Or An Artifact?
Mengyue Yin, Flavia Storelli and Jashvant D. Unadkat

Drug Metabolism and Disposition March 29, 2022, DMD-AR-2022-000849; DOI: https://doi.org/10.1124/dmd.122.000849

March 26, 2022

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Predicting impact of food and feeding time on oral absorption of drugs with a novel rat continuous intestinal absorption model
Casey Radice, Ken Korzekwa and Swati Nagar

Drug Metabolism and Disposition March 26, 2022, DMD-AR-2022-000831; DOI: https://doi.org/10.1124/dmd.122.000831

March 20, 2022

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Localization of Xenobiotic Transporters Expressed at the Human Blood-Testis Barrier
Raymond K. Hau, Robert R Klein, Stephen H. Wright and Nathan J Cherrington

Drug Metabolism and Disposition March 20, 2022, DMD-AR-2021-000748; DOI: https://doi.org/10.1124/dmd.121.000748
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Label-Free but Still Constrained: Assessment of Global Proteomic Strategies for the Quantification of Hepatic Enzymes and Transporters
Jill Barber, Zubida M. Al-Majdoub, Narciso Couto, Areti-Maria Vasilogianni, Annika Tillmann, Sarah Alrubia, Amin Rostami-Hodjegan and Brahim Achour

Drug Metabolism and Disposition March 20, 2022, DMD-AR-2021-000780; DOI: https://doi.org/10.1124/dmd.121.000780

March 19, 2022

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A Cross Company Perspective on the Assessment of Therapeutic Protein Biotransformation
Markus Walles, Michael J Berna, Wenying Jian, Simon Hauri, Shawna Hengel, Lloyd King, John C Tran, Cong Wei, Keyang Xu and Xiaochun Zhu

Drug Metabolism and Disposition March 19, 2022, DMD-MR-2021-000462; DOI: https://doi.org/10.1124/dmd.121.000462

March 02, 2022

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Clinical relevance of the constitutive androstane receptor
Sydney Stern, Ritika Kurian and Hongbing Wang

Drug Metabolism and Disposition March 2, 2022, DMD-MR-2021-000483; DOI: https://doi.org/10.1124/dmd.121.000483

February 27, 2022

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Adverse Drug Reactions and Toxicity of the FDA-approved Antisense Oligonucleotide Drugs
Feryal Alhamadani, Kristy Zhang, Rajvi Parikh, Hangyu Wu, Theodore P Rasmussen, Raman Bahal, Xiao-bo Zhong and Jose E. Manautou

Drug Metabolism and Disposition February 27, 2022, DMD-MR-2021-000418; DOI: https://doi.org/10.1124/dmd.121.000418
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Absorption, distribution, metabolism, and excretion of FDA-approved antisense oligonucleotide drugs
Julia M Migliorati, Sunna Liu, Anna Liu, Anagha Gogate, Sreenidhi Nair, Raman Bahal, Theodore P Rasmussen, Jose E. Manautou and Xiao-bo Zhong

Drug Metabolism and Disposition February 27, 2022, DMD-MR-2021-000417; DOI: https://doi.org/10.1124/dmd.121.000417

February 23, 2022

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Mathematical models to characterize the absorption, distribution, metabolism, and excretion (ADME) of protein therapeutics
Shufang Liu and Dhaval K Shah

Drug Metabolism and Disposition February 23, 2022, DMD-MR-2021-000460; DOI: https://doi.org/10.1124/dmd.121.000460
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CYP2C19 plays a major role in the hepatic N-oxidation of cotinine
Yadira X Perez-Paramo, Christy J.W. Watson, Gang Chen and Philip Lazarus

Drug Metabolism and Disposition February 23, 2022, DMD-AR-2021-000624; DOI: https://doi.org/10.1124/dmd.121.000624

February 22, 2022

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From Steroid and Drug Metabolism to Glycobiology, Using Sulfotransferase Structures to Understand and Tailor Function
Lars C Pedersen, MyeongJin Yi, Lee G. Pedersen and Andrea M Kaminski

Drug Metabolism and Disposition February 22, 2022, DMD-MR-2021-000478; DOI: https://doi.org/10.1124/dmd.121.000478
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Clinical Applications and the Roles of Transporters in Disposition, Tumor Targeting, and Tissue Toxicity of meta-Iodobenzylguanidine (mIBG)
Antonio J Lopez Quiñones, Leticia Salvador Vieira and Joanne Wang

Drug Metabolism and Disposition February 22, 2022, DMD-MR-2021-000707; DOI: https://doi.org/10.1124/dmd.121.000707

February 19, 2022

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Distinct roles of the sister nuclear receptors PXR and CAR in liver cancer development
Kouichi Yoshinari and Ryota Shizu

Drug Metabolism and Disposition February 19, 2022, DMD-MR-2021-000481; DOI: https://doi.org/10.1124/dmd.121.000481
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Searching for CAR modulators
Paavo Honkakoski

Drug Metabolism and Disposition February 19, 2022, DMD-MR-2021-000482; DOI: https://doi.org/10.1124/dmd.121.000482

February 12, 2022

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Amino Acid Solute Carrier Transporters in Inflammation and Autoimmunity
Linlin Sheng, Qi Luo and Ligong Chen

Drug Metabolism and Disposition February 12, 2022, DMD-AR-2021-000705; DOI: https://doi.org/10.1124/dmd.121.000705

February 11, 2022

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Absorption, Distribution, Metabolism, and Excretion (ADME) of Therapeutic Proteins: Current Industry Practices and Future Perspectives
Jayaprakasam Bolleddula, Kevin Brady, Gerard Bruin, Anthony J Lee, Jennifer A Martin, Markus Walles, Keyang Xu, Tong-Yuan Yang, Xiaochun Zhu and Hongbin Yu

Drug Metabolism and Disposition February 11, 2022, DMD-MR-2021-000461; DOI: https://doi.org/10.1124/dmd.121.000461
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Characterizing the pharmacokinetics and biodistribution of therapeutic proteins: an industry white paper
Kathryn Ball, Gerard Bruin, Enrique Escandon, Christoph Funk, Joao NS Pereira, Tong-Yuan Yang and Hongbin Yu

Drug Metabolism and Disposition February 11, 2022, DMD-MR-2021-000463; DOI: https://doi.org/10.1124/dmd.121.000463

January 22, 2022

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The in vivo pharmacokinetics of block copolymers containing polyethylene glycol used in nanocarrier drug delivery systems
Lei Yin, Yiling Pang, Lin Shan and Jingkai Gu

Drug Metabolism and Disposition January 22, 2022, DMD-MR-2021-000568; DOI: https://doi.org/10.1124/dmd.121.000568

January 06, 2022

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Regulation of Placental Efflux Transporters During Pregnancy Complications
Danielle Kozlosky, Emily Barrett and Lauren M. Aleksunes

Drug Metabolism and Disposition January 6, 2022, DMD-MR-2021-000449; DOI: https://doi.org/10.1124/dmd.121.000449

December 17, 2021

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Attenuated Ochratoxin A Transporter Expression in a Mouse Model of Nonalcoholic Steatohepatitis Protects against Proximal Convoluted Tubule Toxicity.
Joseph L. Jilek, Kayla L. FROST, Solène MARIE, Cassandra M. MYERS, Michael GOEDKEN, Stephen H. Wright and Nathan J. CHERRINGTON

Drug Metabolism and Disposition December 17, 2021, DMD-MR-2021-000451; DOI: https://doi.org/10.1124/dmd.121.000451
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Emerging Roles of the Human Solute Carrier 22 Family
Sook Wah Yee and Kathleen M. Giacomini

Drug Metabolism and Disposition December 17, 2021, DMD-MR-2021-000702; DOI: https://doi.org/10.1124/dmd.121.000702

December 14, 2021

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Regulation of transporters by perfluorinated carboxylic acids in HepaRG cells
Joe Jongpyo Lim, Youjun Suh, Elaine M Faustman and Julia Yue Cui

Drug Metabolism and Disposition December 14, 2021, DMD-AR-2021-000477; DOI: https://doi.org/10.1124/dmd.121.000477

December 03, 2021

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Mechanistic study on the species differences in excretion pathway of HR011303 in human and rats
Zitao Guo, Mengling Liu, Jian Meng, Yaru Xue, Qi Huang, Yuandong Zheng, Yali Wu, Zhendong Chen, Jinghua Yu, Dafang Zhong, Guangze Li, Xiaoyan Chen and Xingxing Diao

Drug Metabolism and Disposition December 3, 2021, DMD-AR-2021-000582; DOI: https://doi.org/10.1124/dmd.121.000582
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Pharmacokinetics, Mass Balance, and Metabolism of the Novel URAT1 Inhibitor [¹⁴C]HR011303 in Humans: Metabolism is Mediated Predominantly by UDP-glucuronosyltransferase
Yuandong Zheng, Hua Zhang, Mengling Liu, Guangze Li, Sheng Ma, Zhe Zhang, Hongda Lin, Yan Zhan, Zhendong Chen, Dafang Zhong, Liyan Miao and Xingxing Diao

Drug Metabolism and Disposition December 3, 2021, DMD-AR-2021-000581; DOI: https://doi.org/10.1124/dmd.121.000581

August 04, 2021

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Augmented clearance of nivolumab is associated with renal functions in chronic renal disease model rats
Kazuaki Taguchi, Yukitaka Hayashi, Mayu Ohuchi, Hotaka Yamada, Shigehiro Yagishita, Yuki Enoki, Kazuaki Matsumoto and Akinobu Hamada

Drug Metabolism and Disposition August 4, 2021, DMD-AR-2021-000520; DOI: https://doi.org/10.1124/dmd.121.000520

June 29, 2021

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The Nonclinical Disposition and PK/PD Properties of GalNAc-conjugated siRNA Are Highly Predictable and Build Confidence in Translation to Man
Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher R. Brown, Elena Castellanos-Rizaldos, Klaus Charisse, Saeho Chong, Joseph Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale Guenther, Bahru Habtemariam, Vasant Jadhav, Maja Janas, Muthusamy Jayaraman, Jeffrey Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Christopher Maclauchlin, Martin Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel Robbie, Karyn Schmidt, Peter Smith, Christopher Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev and Jing-Tao Wu

Drug Metabolism and Disposition June 29, 2021, DMD-MR-2021-000428; DOI: https://doi.org/10.1124/dmd.121.000428

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