Fast Forward

DMD Fast Forward contains papers in manuscript form that have been accepted and published in DMD but have not been copyedited and have not been assigned to an issue of the journal. Copyediting may lead to some differences between the Fast Forward version and the final version. There may also be differences in the quality of the graphics. The publication date appears below each title followed by the article's unique Digital Object Identifier (DOI).

September 17, 2020

You have access
A two-tiered in vitro approach to de-risk drug candidates for potential bile salt export pump inhibition liabilities in drug discovery
Michael J. Hafey, Robert Houle, Keith Q. Tanis, Ian Knemeyer, Jackie Shang, Qing Chen, Andreas Baudy, James Monroe, Frank D. Sistare and Raymond Evers

Drug Metabolism and Disposition September 17, 2020, DMD-AR-2020-000086; DOI: https://doi.org/10.1124/dmd.120.000086

September 06, 2020

You have access
A laboratory specific scaling factor to predict the in vivo human clearance of aldehyde oxidase substrates
Mailys De Sousa Mendes, Alexandra Orton, Helen Humphries, Barry C. Jones, Iain Gardner, Sibylle Neuhoff and Venkatesh Reddy

Drug Metabolism and Disposition September 6, 2020, DMD-AR-2020-000082; DOI: https://doi.org/10.1124/dmd.120.000082

September 05, 2020

You have access
Functional consequences of pravastatin isomerization on OATP1B1 mediated transport
Jonathan B. Wagner, Melissa Ruggiero, J. Steven Leeder and Bruno Hagenbuch

Drug Metabolism and Disposition September 5, 2020, DMD-AR-2020-000122; DOI: https://doi.org/10.1124/dmd.120.000122
You have access
Characterization of Seasonal Pharmacokinetic Variability in Woodchucks
Jim Zheng, Scott Balsitis, Rex Santos, Bill J Smith and Raju Subramanian

Drug Metabolism and Disposition September 5, 2020, DMD-AR-2020-000140; DOI: https://doi.org/10.1124/dmd.120.000140

September 01, 2020

You have access
Generation and Characterization of Cytochrome P450 2J3/10 CRISPR/Cas9 Knockout Rat Model
Jian Lu, Ang Chen, Xinrun Ma, Xuyang Shang, Yuanjin Zhang, Yuanqing Guo, Mingyao Liu and Xin Wang

Drug Metabolism and Disposition September 1, 2020, DMD-AR-2020-000114; DOI: https://doi.org/10.1124/dmd.120.000114
You have access
Effects of Multiple Doses of Dichloroacetate on GSTZ1 Expression and Activity in Liver and Extrahepatic Tissues of Young and Adult Rats
Edwin J. Squirewell, Marci G. Smeltz, Laura Rowland Faux, Lloyd P. Horne, Peter W. Stacpoole and Margaret O. James

Drug Metabolism and Disposition September 1, 2020, DMD-AR-2020-000142; DOI: https://doi.org/10.1124/dmd.120.000142
You have access
Exposure of Rats to Multiple Oral Doses of Dichloroacetate Results in Upregulation of Hepatic GSTs and NQO1
Edwin J. Squirewell, Ricky Mareus, Lloyd P. Horne, Peter W. Stacpoole and Margaret O. James

Drug Metabolism and Disposition September 1, 2020, DMD-AR-2020-000143; DOI: https://doi.org/10.1124/dmd.120.000143

August 29, 2020

You have access
Impact of P-glycoprotein-mediated active efflux on drug distribution into lumbar cerebrospinal fluid in nonhuman primates
Yoko Nagaya, Kazuhide Katayama, Hiroyuki Kusuhara and Yoshitane Nozaki

Drug Metabolism and Disposition August 29, 2020, DMD-AR-2020-000099; DOI: https://doi.org/10.1124/dmd.120.000099
You have access
Evaluation of in vitro models for assessment of human intestinal metabolism in drug discovery
Mari Davies, Prabha Peramuhendige, Lloyd King, Melanie Golding, Apoorva Kotian, Mark Penney, Syeda Shah and Nenad Manevski

Drug Metabolism and Disposition August 29, 2020, DMD-AR-2020-000111; DOI: https://doi.org/10.1124/dmd.120.000111

August 26, 2020

You have access
The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites
Brian D. Chapron, Jean C. Dinh, Paul C. Toren, Andrea Gaedigk and J. Steven Leeder

Drug Metabolism and Disposition August 26, 2020, DMD-AR-2020-000188; DOI: https://doi.org/10.1124/dmd.120.000188
You have access
Evaluation of the disconnect between hepatocyte and microsome intrinsic clearance and in vitro in vivo extrapolation performance.
Beth Williamson, Stephanie Harlfinger and Dermot F McGinnity

Drug Metabolism and Disposition August 26, 2020, DMD-AR-2020-000131; DOI: https://doi.org/10.1124/dmd.120.000131

August 25, 2020

You have access
Pharmacokinetics and Catabolism of [³H]TAK-164, a Guanylyl Cyclase C Targeted Antibody-Drug Conjugate
Jayaprakasam Bolleddula, Abhi Shah, Mohammad Shadid, Afrand Kamali, Michael D. Smith and Swapan K. Chowdhury

Drug Metabolism and Disposition August 25, 2020, DMD-AR-2020-000194; DOI: https://doi.org/10.1124/dmd.120.000194
You have access
Successful prediction of PET-imaged metformin hepatic uptake clearance in humans using the quantitative proteomics-informed relative expression factor approach
Madhav Sachar, Vineet Kumar, Lars C. Gormsen, Ole Lajord Munk and Jashvant D. Unadkat

Drug Metabolism and Disposition August 25, 2020, DMD-AR-2020-000156; DOI: https://doi.org/10.1124/dmd.120.000156

August 24, 2020

You have access
(-)-N-3-Benzylphenobarbital is superior to omeprazole and (+)-N-3-benzylnirvanol as a CYP2C19 inhibitor in suspended human hepatocytes
Marie-Lynn Cuypers, Hugues Chanteux, Eric Gillent, Pierre Bonnaillie, Kenneth Saunders, Claire Beckers, Claude Delatour, Sylvie Dell'Aiera, Anna-Lena Ungell and Johan Nicolaï

Drug Metabolism and Disposition August 24, 2020, DMD-AR-2020-000089; DOI: https://doi.org/10.1124/dmd.120.000089
You have access
Characterization of Tissue Distribution, Catabolism and Elimination of an Anti-Staphylococcus aureus THIOMAB^TM Antibody-Antibiotic Conjugate in Rats
Hao Cai, Victor Yip, M. Violet Lee, Sylvia Wong, Ola Saad, Shuguang Ma, Nina Ljumanovic, S. Cyrus Khojasteh, Amrita V. Kamath and Ben-Quan Shen

Drug Metabolism and Disposition August 24, 2020, DMD-AR-2020-000092; DOI: https://doi.org/10.1124/dmd.120.000092

Main menu

User menu

Search