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Exposure to High-Altitude Environment is Associated with Drug Transporters Change: miR-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters under Hypoxia
Yabin Duan, Xue Bai, Jianxin Yang, Yang Zhou, Wenqi Gu, Guiqin Liu, Qian Wang, Junbo Zhu, Linli La and Xiangyang Li

Drug Metabolism and Disposition November 29, 2021, DMD-AR-2021-000681; DOI: https://doi.org/10.1124/dmd.121.000681
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Characterization of Cytosolic Glutathione S-Transferases Involved in the Metabolism of the Aromatase Inhibitor, Exemestane
Irina Teslenko, Christy J.W. Watson, Zuping Xia, Gang Chen and Philip Lazarus

Drug Metabolism and Disposition December 2021, 49 (12) 1047-1055; DOI: https://doi.org/10.1124/dmd.121.000635
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Endogenous Plasma Kynurenic Acid in Human: A Newly Discovered Biomarker for Drug-Drug Interactions Involving Organic Anion Transporter 1 and 3 Inhibition
Jennifer Tang, Hong Shen, Xiaofeng Zhao, Vinay K. Holenarsipur, T. Thanga Mariappan, Yueping Zhang, Erika Panfen, Jim Zheng, W. Griffith Humphreys and Yurong Lai

Drug Metabolism and Disposition December 2021, 49 (12) 1063-1069; DOI: https://doi.org/10.1124/dmd.121.000486
Open Access
Ontogeny of Small Intestinal Drug Transporters and Metabolizing Enzymes Based on Targeted Quantitative Proteomics
Márton Kiss, Richard Mbasu, Johan Nicolaï, Karin Barnouin, Apoorva Kotian, Miriam G. Mooij, Nico Kist, Rene M. H. Wijnen, Anna-Lena Ungell, Paul Cutler, Frans G. M. Russel and Saskia N. de Wildt

Drug Metabolism and Disposition December 2021, 49 (12) 1038-1046; DOI: https://doi.org/10.1124/dmd.121.000559
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HLM-beads: Rapid Assessment of Nonspecific Binding to Human Liver Microsomes Using Magnetizable Beads
Ting Wang, Andrea Whitcher-Johnstone, Monica Keith-Luzzi and Tom S. Chan

Drug Metabolism and Disposition December 2021, 49 (12) 1056-1062; DOI: https://doi.org/10.1124/dmd.121.000575
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Predictive In Vitro-In Vivo Extrapolation for Time Dependent Inhibition of CYP1A2, CYP2C8, CYP2C9, CYP2C19 and CYP2D6 Using Pooled Human Hepatocytes, Human Liver Microsomes, and a Simple Mechanistic Static Model
Diane Ramsden, Elke S. Perloff, Andrea Whitcher-Johnstone, Thuy Ho, Reena Patel, Kirk D. Kozminski, Cody L. Fullenwider and J George Zhang

Drug Metabolism and Disposition November 17, 2021, DMD-AR-2021-000718; DOI: https://doi.org/10.1124/dmd.121.000718
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Metabolism of a selective serotonin and norepinephrine reuptake inhibitor duloxetine in liver microsomes and mice
Xuan Qin, John M. Hakenjos, Kevin R. MacKenzie, Mercedes Barzi, Hemantkumar Chavan, Pranavanand Nyshadham, Jin Wang, Sung Yun Jung, Joie Z. Guner, Si Chen, Lei Guo, Partha Krishnamurthy, Karl-Dimiter Bissig, Stephen Palmer, Martin M. Matzuk and Feng Li

Drug Metabolism and Disposition November 16, 2021, DMD-AR-2021-000633; DOI: https://doi.org/10.1124/dmd.121.000633
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Environmental Chemical Contribution to the Modulation of Bile Acid Homeostasis and Farnesoid X Receptor Signaling
Rulaiha Elizabeth Taylor, Anisha Bhattacharya and Grace L. Guo

Drug Metabolism and Disposition November 10, 2021, DMD-MR-2021-000388; DOI: https://doi.org/10.1124/dmd.121.000388
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The Lack of Contribution of 7-Hydroxymitragynine to the Antinociceptive Effects of Mitragynine in Mice: A Pharmacokinetic and Pharmacodynamic Study
Erin C Berthold, Shyam H Kamble, Kanumuri S Raju, Michelle A Kuntz, Alexandria S Senetra, Marco Mottinelli, Francisco León, Luis F Restrepo, Avi Patel, Nicholas P Ho, Takato Hiranita, Abhisheak Sharma, Lance R. McMahon and Christopher R. McCurdy

Drug Metabolism and Disposition November 10, 2021, DMD-AR-2021-000640; DOI: https://doi.org/10.1124/dmd.121.000640
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Permeabilized cryopreserved human hepatocytes as an exogenous metabolic system in a novelmetabolism-dependent cytotoxicity assay (MDCA) for the evaluation of metabolic activation anddetoxification of drugs associated with drug induced liver injuries: Results with acetaminophen,amiodarone, cyclophosphamide, ketoconazole, nefazodone, and troglitazone
Hong Wei and Albert P. Li

Drug Metabolism and Disposition November 8, 2021, DMD-AR-2021-000645; DOI: https://doi.org/10.1124/dmd.121.000645

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