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Investigating the Utility of Humanized PXR-CAR-CYP3A4/7 Mouse Model to Assess CYP3A-Mediated Induction
Justin Q. Ly, Susan Wong, Liling Liu, Ruina Li, Kirsten Messick and Jae H. Chang

Drug Metabolism and Disposition April 16, 2021, DMD-AR-2021-000439; DOI: https://doi.org/10.1124/dmd.121.000439
Open Access
Absorption, Metabolism, and Excretion, In Vitro Pharmacology, and Clinical Pharmacokinetics of Ozanimod, a Novel Sphingosine 1-Phosphate Receptor Modulator
Sekhar Surapaneni, Usha Yerramilli, April Bai, Deepak Dalvie, Jennifer Brooks, Xiaomin Wang, Julie V. Selkirk, Yingzhuo Grace Yan, Peijin Zhang, Richard Hargreaves, Gondi Kumar, Maria Palmisano and Jonathan Q. Tran

Drug Metabolism and Disposition May 2021, 49 (5) 405-419; DOI: https://doi.org/10.1124/dmd.120.000220
Open Access
SLCO1B1: Application and Limitations of Deep Mutational Scanning for Genomic Missense Variant Function
Lingxin Zhang, Vivekananda Sarangi, Ming-Fen Ho, Irene Moon, Krishna R. Kalari, Liewei Wang and Richard M. Weinshilboum

Drug Metabolism and Disposition May 2021, 49 (5) 395-404; DOI: https://doi.org/10.1124/dmd.120.000264
Open Access
Clinical Investigation of Metabolic and Renal Clearance Pathways Contributing to the Elimination of Fevipiprant Using Probenecid as Perpetrator
H. Markus Weiss, Thomas Langenickel, Meredith Cain, Swarupa Kulkarni, Bharti Shah, Janardhana Vemula, Gholamreza Rahmanzadeh and Birk Poller

Drug Metabolism and Disposition May 2021, 49 (5) 389-394; DOI: https://doi.org/10.1124/dmd.120.000273
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Metabolic Retroversion of Piperaquine (PQ) via Hepatic Cytochrome P450–Mediated N-Oxidation and Reduction: Not an Important Contributor to the Prolonged Elimination of PQ
Yuewu Xie, Yunrui Zhang, Huixiang Liu and Jie Xing

Drug Metabolism and Disposition May 2021, 49 (5) 379-388; DOI: https://doi.org/10.1124/dmd.120.000306
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Tertiary Oxidation of Deoxycholate Is Predictive of CYP3A Activity in Dogs
Wushuang Zeng, Lanlan Gui, Xianwen Tan, Pingping Zhu, Yiting Hu, Qingliang Wu, Xuejing Li, Lian Yang, Wei Jia, Changxiao Liu and Ke Lan

Drug Metabolism and Disposition May 2021, 49 (5) 369-378; DOI: https://doi.org/10.1124/dmd.121.000385
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IVIVE of Transporter-Mediated Renal Clearance: Relative Expression Factor (REF) vs Relative Activity Factor (RAF) Approach
Aditya R. Kumar, Bhagwat Prasad, Deepak Kumar Bhatt, Sumathy Mathialagan, Manthena V. S. Varma and Jashvant D. Unadkat

Drug Metabolism and Disposition April 6, 2021, DMD-AR-2021-000367; DOI: https://doi.org/10.1124/dmd.121.000367
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Pharmacokinetic and biochemical profiling of Sodium Dichloroacetate in pregnant ewes and fetuses
Serene Joseph, Abhisheak Sharma, Lloyd P. Horne, Charles E. Wood, Taimour Langaee, Margaret O. James, Peter W. Stacpoole and Maureen Keller-Wood

Drug Metabolism and Disposition April 2, 2021, DMD-AR-2020-000330; DOI: https://doi.org/10.1124/dmd.120.000330
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Cytochrome P450 3A Time-Dependent Inhibition Assays are Too Sensitive for Identification of Drugs Causing Clinically Significant Drug-Drug Interactions: A Comparison of Human Liver Microsomes and Hepatocytes and Definition of Boundaries for Inactivation Rate Constants
Heather Eng, Elaine Tseng, Matthew A. Cerny, Theunis C. Goosen and R. Scott Obach

Drug Metabolism and Disposition April 2, 2021, DMD-AR-2021-000356; DOI: https://doi.org/10.1124/dmd.121.000356
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Reversible and irreversible inhibition of cytochrome P450 enzymes by methylophiopogonanone A
Dong-Zhu Tu, Xu Mao, Feng Zhang, Rong-Jing He, Jing-Jing Wu, Yue Wu, Xiao-Hua Zhao, Jiang Zheng and Guang-Bo Ge

Drug Metabolism and Disposition April 2, 2021, DMD-AR-2020-000325; DOI: https://doi.org/10.1124/dmd.120.000325

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