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Characterization of Nonclinical Drug Metabolism and Pharmacokinetic Properties of Phosphorodiamidate Morpholino Oligonucleotides, a Novel Drug Class for Duchenne Muscular Dystrophy
Andrew K.L. Goey, Marie Claire Mukashyaka, Yogesh Patel, Louise R. Rodino-Klapac and Lilly East

Drug Metabolism and Disposition December 2024, 52 (12) 1396-1406; DOI: https://doi.org/10.1124/dmd.124.001819
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Differential Selectivity of Human and Mouse ABCC4/Abcc4 for Arsenic Metabolites
Brayden D. Whitlock, Yingze Ma, Gwenaëlle Conseil, Alicia R. O’Brien, Mayukh Banerjee, Diane P. Swanlund, Z. Ping Lin, Yao Wang, X. Chris Le, John D. Schuetz, Susan P.C. Cole and Elaine M. Leslie

Drug Metabolism and Disposition December 2024, 52 (12) 1417-1428; DOI: https://doi.org/10.1124/dmd.124.001852
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Age-Dependent Changes in Cytochrome P450 Abundance and Composition in Human Liver
Sandhya Subash and Bhagwat Prasad

Drug Metabolism and Disposition December 2024, 52 (12) 1363-1372; DOI: https://doi.org/10.1124/dmd.124.001608
Open Access
Absorption, Distribution, Metabolism, and Excretion of Icenticaftor (QBW251) in Healthy Male Volunteers at Steady State and In Vitro Phenotyping of Major Metabolites
Ulrike Glaenzel, Felix Huth, Fabian Eggimann, Melissa Hackling, Luc Alexis Leuthold, Axel Meissner and Lidiya Bebrevska

Drug Metabolism and Disposition December 2024, 52 (12) 1379-1387; DOI: https://doi.org/10.1124/dmd.124.001751
Open Access
CYP P450 and non-CYP P450 Drug Metabolizing Enzyme Families Exhibit Differential Sensitivities towards Proinflammatory Cytokine Modulation
Laura M. de Jong, Chandan Harpal, Dirk-Jan van den Berg, Menno Hoekstra, Nienke J. Peter, Robert Rissmann, Jesse J. Swen and Martijn L. Manson

Drug Metabolism and Disposition December 2024, 52 (12) 1429-1437; DOI: https://doi.org/10.1124/dmd.124.001867
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3-epi-18β-Glycyrrhetinic Acid or Its Glucuronide, the Metabolites of Glycyrrhizinic Acid with Individual Differences, Correlated with Diagnostic Marker for Licorice-Induced Pseudoaldosteronism in Humans
Ryota Sakoda, Kan’ichiro Ishiuchi, Tetsuhiro Yoshino, Yuna Tsunoo, Takao Namiki, Keiko Ogawa-Ochiai, Kiyoshi Minamizawa, Koichi Fukunaga, Kenji Watanabe and Toshiaki Makino

Drug Metabolism and Disposition December 2024, 52 (12) 1407-1416; DOI: https://doi.org/10.1124/dmd.124.001840
Open Access
Utility of Common In Vitro Systems for Predicting Circulating Metabolites
Elyse C. Freiberger, Michael P. Thompson, Xiaomei Zhang, Essence B. Underwood, Thomas L. Lynch, Gary J. Jenkins and David S. Wagner

Drug Metabolism and Disposition December 2024, 52 (12) 1373-1378; DOI: https://doi.org/10.1124/dmd.124.001732
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Quantitative Prediction of Drug-Drug Interactions Caused by CYP3A Induction Using Endogenous Biomarker 4β-Hydroxycholesterol
Hiroaki Takubo, Toshio Taniguchi and Yukihiro Nomura

Drug Metabolism and Disposition December 2024, 52 (12) 1438-1444; DOI: https://doi.org/10.1124/dmd.124.001876
Open Access
Candesartan Has No Clinically Meaningful Effect on the Plasma Concentrations of Cytochrome P450 2C8 Substrate Repaglinide in Humans
Mikael O.W. Piha, Kristiina Cajanus, Marica T. Engström, Mikko Neuvonen, Troels K. Bergmann, Mikko Niemi, Janne T. Backman, Anne M. Filppula and Aleksi Tornio

Drug Metabolism and Disposition December 2024, 52 (12) 1388-1395; DOI: https://doi.org/10.1124/dmd.124.001798
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Impact of Genetic Polymorphisms and Drug-Drug Interactions Mediated by Carboxylesterase1 on Remimazolam Deactivation
Zhuo Wang, Zachary McCalla, Li Lin, Dominic Tornichio, Yaw Agyemang, John A. Bastulli, Xiaochun Susan Zhang, Hao-Jie Zhu and Xinwen Wang

Drug Metabolism and Disposition November 5, 2024, DMD-AR-2024-001916; DOI: https://doi.org/10.1124/dmd.124.001916

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