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Drug Metabolism & Disposition

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Latest Articles

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    Ontogeny of Scaling Factors for Pediatric PBPK Modeling and Simulation: Cytosolic Protein Per Gram of Liver
    Stephani L. Stancil, Robin E. Pearce, Vincent S. Staggs and J. Steven Leeder
    Drug Metabolism and Disposition September 21, 2023, DMD-AR-2023-001417; DOI: https://doi.org/10.1124/dmd.123.001417
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    Quantitative analysis of mRNA and protein expression levels of aldo-keto reductase and short-chain dehydrogenase/reductase isoforms in the human intestine
    Keiya Hirosawa, Hijiri Fujioka, Gaku Morinaga, Tatsuki Fukami, Naoki Ishiguro, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi and Miki Nakajima
    Drug Metabolism and Disposition September 18, 2023, DMD-AR-2023-001402; DOI: https://doi.org/10.1124/dmd.123.001402
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    Potential and Challenges in Application of Physiologically Based Pharmacokinetic Modeling in Predicting Diarrheal Disease Impact on Oral Drug Pharmacokinetics
    Cindy X. Zhang and Samuel L.M. Arnold
    Drug Metabolism and Disposition September 15, 2023, DMD-MR-2022-000964; DOI: https://doi.org/10.1124/dmd.122.000964
  • Utility of Minimal Physiologically Based Pharmacokinetic Models for Assessing Fractional Distribution, Oral Absorption, and Series-Compartment Models of Hepatic Clearance
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    Utility of Minimal Physiologically Based Pharmacokinetic Models for Assessing Fractional Distribution, Oral Absorption, and Series-Compartment Models of Hepatic Clearance
    Xiaonan Li and William J. Jusko
    Drug Metabolism and Disposition October 2023, 51 (10) 1403-1418; DOI: https://doi.org/10.1124/dmd.123.001403
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    NEAT1_2 and DAZAP1, Paraspeckle Components, Interact with PXR to Negatively Regulate CYP3A4 Induction
    Rei Mitamura, Masataka Nakano, Motoki Isono, Kiamu Kurosawa, Tatsuki Fukami and Miki Nakajima
    Drug Metabolism and Disposition October 2023, 51 (10) 1230-1237; DOI: https://doi.org/10.1124/dmd.122.001065
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    Special Section on New and Emerging Areas and Technologies in Drug Metabolism and Disposition, Part I–Editorial
    Xiao-bo Zhong, Yurong Lai and Xinxin Ding
    Drug Metabolism and Disposition October 2023, 51 (10) 1227-1229; DOI: https://doi.org/10.1124/dmd.123.001480
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    Challenges and Opportunities in P450 Research on the Eye
    Irina A. Pikuleva
    Drug Metabolism and Disposition October 2023, 51 (10) 1295-1307; DOI: https://doi.org/10.1124/dmd.122.001072
  • Interpretation of Protein-Mediated Uptake of Statins by Hepatocytes Is Confounded by the Residual Statin-Protein Complex
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    Interpretation of Protein-Mediated Uptake of Statins by Hepatocytes Is Confounded by the Residual Statin-Protein Complex
    Mengyue Yin, Kazuya Ishida, Xiaomin Liang, Yurong Lai and Jashvant D. Unadkat
    Drug Metabolism and Disposition October 2023, 51 (10) 1381-1390; DOI: https://doi.org/10.1124/dmd.123.001386
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    Dissecting Parameters Contributing to the Underprediction of Aldehyde Oxidase-Mediated Metabolic Clearance of Drugs
    Sandhya Subash, Dilip K. Singh, Deepak S. Ahire, S. Cyrus Khojasteh, Bernard P. Murray, Michael A. Zientek, Robert S. Jones, Priyanka Kulkarni, Bill J. Smith, Scott Heyward, Ciarán N. Cronin and Bhagwat Prasad
    Drug Metabolism and Disposition October 2023, 51 (10) 1362-1371; DOI: https://doi.org/10.1124/dmd.123.001379
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    Bioanalytical Assays for Pharmacokinetic and Biodistribution Study of Antibody-Drug Conjugates
    Lei Yin, Aiyun Xu, Yumeng Zhao and Jingkai Gu
    Drug Metabolism and Disposition October 2023, 51 (10) 1324-1331; DOI: https://doi.org/10.1124/dmd.123.001313

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