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Evaluation of Normothermic Machine Perfusion of Porcine Livers as a Novel Preclinical Model to Predict Biliary Clearance and Transporter-mediated Drug-Drug Interactions using Statins
Lianne J. Stevens, Andy Z.X. Zhu, Paresh P. Chothe, Swapan K. Chowdhury, Joanne M. Donkers, Wouter H.J. Vaes, Catherijne A.J. Knibbe, Ian P.J. Alwayn and Evita van de Steeg

Drug Metabolism and Disposition July 30, 2021, DMD-AR-2021-000521; DOI: https://doi.org/10.1124/dmd.121.000521
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Cytochrome b₅ Binds Tightly to Several Human Cytochrome P450 Enzymes
Donghak Kim, Vitchan Kim, Yasuhiro Tateishi and F. Peter Guengerich

Drug Metabolism and Disposition July 30, 2021, DMD-AR-2021-000475; DOI: https://doi.org/10.1124/dmd.121.000475
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Cytochrome P450-Catalyzed Metabolism of Cannabidiol to the Active Metabolite 7-Hydroxy-Cannabidiol
Jessica L Beers, Dong Fu and Klarissa D. Jackson

Drug Metabolism and Disposition July 30, 2021, DMD-AR-2020-000350; DOI: https://doi.org/10.1124/dmd.120.000350
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Quantitation of plasma membrane drug transporters in kidney tissue and cell lines using a novel proteomic approach enabled a prospective prediction of metformin disposition
Ryota Kikuchi, William J. Chiou, Kenneth R. Durbin, John P. Savaryn, Junli Ma, Arian Emami Riedmaier, Sonia M. de Morais, Gary J. Jenkins and Daniel A.J. Bow

Drug Metabolism and Disposition July 30, 2021, DMD-AR-2021-000487; DOI: https://doi.org/10.1124/dmd.121.000487
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Static and Dynamic Projections of Drug-Drug Interactions Caused by Cytochrome P450 3A Time-Dependent Inhibitors Measured in Human Liver Microsomes and Hepatocytes
Elaine Tseng, Heather Eng, Jian Lin, Matthew A. Cerny, David A. Tess, Theunis C. Goosen and R. Scott Obach

Drug Metabolism and Disposition July 29, 2021, DMD-AR-2021-000497; DOI: https://doi.org/10.1124/dmd.121.000497
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Tetrahydrocannabinol and Its Major Metabolites are Not (or are poor) Substrates or Inhibitors of Human P-glycoprotein (P-gp/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2)
Xin Chen, Jashvant D. Unadkat and Qingcheng Mao

Drug Metabolism and Disposition July 29, 2021, DMD-AR-2021-000505; DOI: https://doi.org/10.1124/dmd.121.000505
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Infigratinib is a Reversible Inhibitor and Mechanism-based Inactivator of Cytochrome P450 3A4
Lloyd Wei Tat Tang, Jian Wei Teng, Siew Kwan Koh, Lei Zhou, Mei Lin Go, Eric Chun Yong Chan, Ravi Kumar Verma and Hao Fan

Drug Metabolism and Disposition July 29, 2021, DMD-AR-2021-000508; DOI: https://doi.org/10.1124/dmd.121.000508
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Preclinical Drug Metabolism, Pharmacokinetic, and Pharmacodynamic Profiles of Ivosidenib, an Inhibitor of Mutant IDH1 for Treatment of IDH1-Mutant Malignancies
Yue Chen, Nelamangala V. Nagaraja, Bin Fan, Luke Utley, Rene M. Lemieux, Janeta Popovici-Muller, Lenny Dang, Hyeryun Kim, Liping Yan, Shin-San M. Su, Scott A. Biller and Hua Yang

Drug Metabolism and Disposition July 28, 2021, DMD-AR-2020-000234; DOI: https://doi.org/10.1124/dmd.120.000234
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Prediction of pregnancy-induced changes in secretory and total renal clearance of drugs transported by organic anion transporters
Jinfu Peng, Mayur K Ladumor and Jashvant D. Unadkat

Drug Metabolism and Disposition July 27, 2021, DMD-AR-2021-000557; DOI: https://doi.org/10.1124/dmd.121.000557
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Icotinib induces mechanism-based inactivation of rhCYP3A4/5 possibly via heme destruction by ketene intermediate
Chen Sun, Huimin Zhao, Wei Li, Yudi Jia, Yi Yang, Ying Peng and Jiang Zheng

Drug Metabolism and Disposition July 26, 2021, DMD-AR-2021-000369; DOI: https://doi.org/10.1124/dmd.121.000369

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