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In Vivo Functional Effects of CYP2C9 M1L, a Novel and Common Variant in the Yup'ik Alaska Native Population
Lindsay M. Henderson, Scarlett E. Hopkins, Bert B. Boyer, Timothy A. Thornton, Allan E. Rettie and Kenneth E. Thummel

Drug Metabolism and Disposition February 25, 2021, DMD-AR-2020-000301; DOI: https://doi.org/10.1124/dmd.120.000301
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Clinical investigation of metabolic and renal clearance pathways contributing to the elimination of fevipiprant using probenecid as perpetrator
H. Markus Weiss, Thomas Langenickel, Meredith Cain, Swarupa Kulkarni, Bharti Shah, Janardhana Vemula, Gholamreza Rahmanzadeh and Birk Poller

Drug Metabolism and Disposition February 25, 2021, DMD-AR-2020-000273; DOI: https://doi.org/10.1124/dmd.120.000273
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Evaluation of Tissue Binding in 3 Tissues Across 5 Species, and Prediction of Volume of Distribution from Plasma Protein and Tissue Binding
Frederick Hsu, Yi-Chen Chen and Fabio Broccatelli

Drug Metabolism and Disposition February 25, 2021, DMD-AR-2020-000337; DOI: https://doi.org/10.1124/dmd.120.000337
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Correction to “Absorption, Distribution, Metabolism, and Excretion of the Oral Prostaglandin D2 Receptor 2 Antagonist Fevipiprant (QAW039) in Healthy Volunteers and In Vitro”
Drug Metabolism and Disposition March 2021, 49 (3) 287-288; DOI: https://doi.org/10.1124/dmd.117.075358err
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Prediction of Transporter-Mediated Drug-Drug Interactions and Phenotyping of Hepatobiliary Transporters Involved in the Clearance of E7766, a Novel Macrocycle-Bridged Dinucleotide
Rongrong Jiang, Andrew Hart, Laurette Burgess, Dae-Shik Kim, Weidong George Lai and Vaishali Dixit

Drug Metabolism and Disposition March 2021, 49 (3) 265-275; DOI: https://doi.org/10.1124/dmd.120.000125
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Evaluation of the Utility of PXB Chimeric Mice for Predicting Human Liver Partitioning of Hepatic Organic Anion-Transporting Polypeptide Transporter Substrates
Bo Feng, Rachel Pemberton, Wojciech Dworakowski, Zhengqi Ye, Craig Zetterberg, Guanyu Wang, Yoshio Morikawa and Sanjeev Kumar

Drug Metabolism and Disposition March 2021, 49 (3) 254-264; DOI: https://doi.org/10.1124/dmd.120.000276
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Evaluation of Tissue Stem Cell–Derived Human Intestinal Organoids, a Physiologically Relevant Model to Evaluate Cytochrome P450 Induction in Gut
David M. Stresser, Jun Sun and Sarah S. Wilson

Drug Metabolism and Disposition March 2021, 49 (3) 245-253; DOI: https://doi.org/10.1124/dmd.120.000281
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The Hypoglycemic Effect of Berberine and Berberrubine Involves Modulation of Intestinal Farnesoid X Receptor Signaling Pathway and Inhibition of Hepatic Gluconeogenesis
Runbin Sun, Bo Kong, Na Yang, Bei Cao, Dong Feng, Xiaoyi Yu, Chun Ge, Siqi Feng, Fei Fei, Jingqiu Huang, Zhenyao Lu, Yuan Xie, Chung S. Yang, Grace L. Guo, Guangji Wang and Jiye Aa

Drug Metabolism and Disposition March 2021, 49 (3) 276-286; DOI: https://doi.org/10.1124/dmd.120.000215
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Functional Characterization of 40 CYP3A4 Variants by Assessing Midazolam 1′-Hydroxylation and Testosterone 6β-Hydroxylation
Masaki Kumondai, Evelyn Marie Gutiérrez Rico, Eiji Hishinuma, Akiko Ueda, Sakae Saito, Daisuke Saigusa, Shu Tadaka, Kengo Kinoshita, Tomoki Nakayoshi, Akifumi Oda, Ai Abe, Masamitsu Maekawa, Nariyasu Mano, Noriyasu Hirasawa and Masahiro Hiratsuka

Drug Metabolism and Disposition March 2021, 49 (3) 212-220; DOI: https://doi.org/10.1124/dmd.120.000261
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Impact of Plasma Protein Binding in Drug Clearance Prediction: A Database Analysis of Published Studies and Implications for In Vitro-In Vivo Extrapolation
L. J. Francis, J. B. Houston and D. Hallifax

Drug Metabolism and Disposition March 2021, 49 (3) 188-201; DOI: https://doi.org/10.1124/dmd.120.000294

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