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High-Throughput Production of Diverse Xenobiotic Metabolites with Cytochrome P450–Transduced Huh7 Hepatoma Cell Lines
Choon-myung Lee, Ken H. Liu, Grant Singer, Gary W. Miller, Shuzhao Li, Dean P. Jones and Edward T. Morgan

Drug Metabolism and Disposition September 2022, 50 (9) 1182-1189; DOI: https://doi.org/10.1124/dmd.122.000900
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The rs35217482 (T755I) Single-Nucleotide Polymorphism in Aldehyde Oxidase-1 Attenuates Protein Dimer Formation and Reduces the Rates of Phthalazine Metabolism
Hinata Ueda, Katsuya Narumi, Ayako Furugen, Yoshitaka Saito and Masaki Kobayashi

Drug Metabolism and Disposition September 2022, 50 (9) 1126-1131; DOI: https://doi.org/10.1124/dmd.122.000902
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The COVID-19 Oral Drug Molnupiravir Is a CES2 Substrate: Potential Drug-Drug Interactions and Impact of CES2 Genetic Polymorphism In Vitro
Yue Shen, William Eades, William Liu and Bingfang Yan

Drug Metabolism and Disposition September 2022, 50 (9) 1151-1160; DOI: https://doi.org/10.1124/dmd.122.000918
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Physiologically Based Pharmacokinetic Modeling of Vitamin D₃ and Metabolites in Vitamin D–Insufficient Patients
Colton W. Sawyer, Stacey M. Tuey, Raymond E. West, Thomas D. Nolin and Melanie S. Joy

Drug Metabolism and Disposition September 2022, 50 (9) 1161-1169; DOI: https://doi.org/10.1124/dmd.121.000609
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Physiologically Based Pharmacokinetic Models Can Be Used to Predict the Unique Nonlinear Absorption Profiles of Vismodegib
Louis Lin, Matthew R. Wright, Cornelis E.C.A. Hop and Harvey Wong

Drug Metabolism and Disposition September 2022, 50 (9) 1170-1181; DOI: https://doi.org/10.1124/dmd.122.000885
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Is the Protein-Mediated Uptake of Drugs by Organic Anion Transporting Polypeptides a Real Phenomenon or an Artifact?
Mengyue Yin, Flavia Storelli and Jashvant D. Unadkat

Drug Metabolism and Disposition September 2022, 50 (9) 1132-1141; DOI: https://doi.org/10.1124/dmd.122.000849
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Antibiotics-Induced Disruption of Gut Microbiota Increases Systemic Exposure of Clopidogrel Active Metabolite in Type 2 Diabetic Rats
Xue Chen, Yingrui Liu, Hongwei Yao, Wenfang Song, Yu Song, Jingkai Gu and Yingjie Guo

Drug Metabolism and Disposition September 2022, 50 (9) 1142-1150; DOI: https://doi.org/10.1124/dmd.122.000906
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Examining Physiologically Based Pharmacokinetic Model Assumptions for Cross-Tissue Similarity of Activity per Unit of Enzyme: The Case Example of Uridine 5′-Diphosphate Glucuronosyltransferase
Anika N. Ahmed, Amin Rostami-Hodjegan, Jill Barber and Zubida M. Al-Majdoub

Drug Metabolism and Disposition August 2022, 50 (8) 1119-1125; DOI: https://doi.org/10.1124/dmd.121.000813
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The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Abrocitinib, a Selective Janus Kinase Inhibitor, in Humans
Jonathan N. Bauman, Angela C. Doran, Amanda King-Ahmad, Raman Sharma, Gregory S. Walker, Jian Lin, Tsung H. Lin, Jean-Baptiste Telliez, Sakambari Tripathy, Theunis C. Goosen, Christopher Banfield, Bimal K. Malhotra and Martin E. Dowty

Drug Metabolism and Disposition August 2022, 50 (8) 1106-1118; DOI: https://doi.org/10.1124/dmd.122.000829
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Application of Empirical Scalars To Enable Early Prediction of Human Hepatic Clearance Using In Vitro-In Vivo Extrapolation in Drug Discovery: An Evaluation of 173 Drugs
Robert S. Jones, Christian Leung, Jae H. Chang, Suzanne Brown, Ning Liu, Zhengyin Yan, Jane R. Kenny and Fabio Broccatelli

Drug Metabolism and Disposition August 2022, 50 (8) 1053-1063; DOI: https://doi.org/10.1124/dmd.121.000784

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