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Contribution of UGT Enzymes to Human Drug Metabolism Stereoselectivity: A Case Study of Medetomidine, RO5263397, Propranolol, and Testosterone
Nicolò Milani, NaHong Qiu and Stephen Fowler

Drug Metabolism and Disposition March 2023, 51 (3) 306-317; DOI: https://doi.org/10.1124/dmd.122.001024
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Hydroxychloroquine is Metabolized by Cytochrome P450 2D6, 3A4, and 2C8, and Inhibits Cytochrome P450 2D6, while its Metabolites also Inhibit Cytochrome P450 3A in vitro
Marie-Noëlle Paludetto, Mika Kurkela, Helinä Kahma, Janne T. Backman, Mikko Niemi and Anne M. Filppula

Drug Metabolism and Disposition March 2023, 51 (3) 293-305; DOI: https://doi.org/10.1124/dmd.122.001018
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Preclinical metabolism and disposition of TP0473292, a novel oral prodrug of the potent metabotropic glutamate 2/3 receptor antagonist TP0178894 for the treatment of depression
Shoko Inatani, Motoki Ochi, Kohnosuke Kinoshita, Jun-ichi Yamaguchi and Hiromi Endo

Drug Metabolism and Disposition February 21, 2023, DMD-AR-2022-001116; DOI: https://doi.org/10.1124/dmd.122.001116
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Maternal and Fetal Exposure to (-)-Δ⁹-tetrahydrocannabinol and Its Major Metabolites in Pregnant Mice Is Differentially Impacted by P-glycoprotein and Breast Cancer Resistance Protein
Xin Chen, Jashvant D. Unadkat and Qingcheng Mao

Drug Metabolism and Disposition March 2023, 51 (3) 269-275; DOI: https://doi.org/10.1124/dmd.122.001110
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Quantitative Cytochrome P450 3A4 Induction Risk Assessment Using Human Hepatocytes Complemented with Pregnane X Receptor-Activating Profiles
Aynur Ekiciler, Wen Li Kelly Chen, Yan Bo, Alessandra Pugliano, Massimiliano Donzelli, Neil Parrott and Kenichi Umehara

Drug Metabolism and Disposition March 2023, 51 (3) 276-284; DOI: https://doi.org/10.1124/dmd.122.001132
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Quantification of Accurate Composition and Total Abundance of Homologous Proteins by Conserved-Plus-Surrogate Peptide Approach: Quantification of UDP Glucuronosyltransferases in Human Tissues
Deepak Ahire, Mitesh Patel, Sujal V. Deshmukh and Bhagwat Prasad

Drug Metabolism and Disposition March 2023, 51 (3) 285-292; DOI: https://doi.org/10.1124/dmd.122.001155
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Correction to “Microbial Metabolites as Ligands to Xenobiotic Receptors: Chemical Mimicry as Potential Drugs of the Future”
Drug Metabolism and Disposition February 2023, 51 (2) 268; DOI: https://doi.org/10.1124/dmd.122.000860err
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A Physiological-Based Pharmacokinetic Model Embedded with a Target-Mediated Drug Disposition Mechanism Can Characterize Single-Dose Warfarin Pharmacokinetic Profiles in Subjects with Various CYP2C9 Genotypes under Different Cotreatments
Shen Cheng, Darcy R. Flora, Allan E. Rettie, Richard C. Brundage and Timothy S. Tracy

Drug Metabolism and Disposition February 2023, 51 (2) 257-267; DOI: https://doi.org/10.1124/dmd.122.001048
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Phenobarbital in Nuclear Receptor Activation: An Update
Shuaiqian Men and Hongbing Wang

Drug Metabolism and Disposition February 2023, 51 (2) 210-218; DOI: https://doi.org/10.1124/dmd.122.000859
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Microbial Metabolites as Ligands to Xenobiotic Receptors: Chemical Mimicry as Potential Drugs of the Future
Zdeněk Dvořák, Hao Li and Sridhar Mani

Drug Metabolism and Disposition February 2023, 51 (2) 219-227; DOI: https://doi.org/10.1124/dmd.122.000860

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