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Dual action of acidic microenvironment on the enrichment of the active metabolite of disulfiram in tumor tissues
Chongzhuang Tang, Xiaoyan Pang, Zitao Guo, Runcong Guo, Lu Liu and Xiaoyan Chen

Drug Metabolism and Disposition March 24, 2021, DMD-AR-2020-000317; DOI: https://doi.org/10.1124/dmd.120.000317
Open Access
In Vivo Functional Effects of CYP2C9 M1L, a Novel and Common Variant in the Yup’ik Alaska Native Population
Lindsay M. Henderson, Scarlett E. Hopkins, Bert B. Boyer, Timothy A. Thornton, Allan E. Rettie and Kenneth E. Thummel

Drug Metabolism and Disposition May 2021, 49 (5) 345-352; DOI: https://doi.org/10.1124/dmd.120.000301
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Role of Human Arylacetamide Deacetylase (AADAC) on Hydrolysis of Eslicarbazepine Acetate and Effects of AADAC Genetic Polymorphisms on Hydrolase Activity
Keiya Hirosawa, Tatsuki Fukami, Kiyomichi Tashiro, Yoshiyuki Sakai, Fumiya Kisui, Masataka Nakano and Miki Nakajima

Drug Metabolism and Disposition April 2021, 49 (4) 322-329; DOI: https://doi.org/10.1124/dmd.120.000295
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Correction to “Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro CYP Induction Studies Including Impact on Drug Interaction Risk Assessment”
Drug Metabolism and Disposition April 2021, 49 (4) 344; DOI: https://doi.org/10.1124/dmd.120.000055err
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Evaluation of Tissue Binding in Three Tissues across Five Species and Prediction of Volume of Distribution from Plasma Protein and Tissue Binding with an Existing Model
Frederick Hsu, Yi-Chen Chen and Fabio Broccatelli

Drug Metabolism and Disposition April 2021, 49 (4) 330-336; DOI: https://doi.org/10.1124/dmd.120.000337
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Maternal and Fetal Pharmacokinetic Analysis of Cannabidiol during Pregnancy in Mice
Wataru Ochiai, Satoshi Kitaoka, Taisuke Kawamura, Jo Hatogai, Shohei Harada, Misa Iizuka, Mashu Ariumi, Seiya Takano, Tomomi Nagai, Masanaho Sasatsu and Kiyoshi Sugiyama

Drug Metabolism and Disposition April 2021, 49 (4) 337-343; DOI: https://doi.org/10.1124/dmd.120.000270
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Function and Expression of Bile Salt Export Pump in Suspension Human Hepatocytes
Paresh P. Chothe, Rachel Pemberton and Niresh Hariparsad

Drug Metabolism and Disposition April 2021, 49 (4) 314-321; DOI: https://doi.org/10.1124/dmd.120.000057
Open Access
Revisiting Nonlinear Bosentan Pharmacokinetics by Physiologically Based Pharmacokinetic Modeling: Target Binding, Albeit Not a Major Contributor to Nonlinearity, Can Offer Prediction of Target Occupancy
Satoshi Koyama, Kota Toshimoto, Wooin Lee, Yasunori Aoki and Yuichi Sugiyama

Drug Metabolism and Disposition April 2021, 49 (4) 298-304; DOI: https://doi.org/10.1124/dmd.120.000023
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In Vitro Evidence of Potential Interactions between CYP2C8 and Candesartan Acyl-β-D-glucuronide in the Liver
Yurie Katsube, Masayuki Tsujimoto, Hiroyoshi Koide, Daiki Hira, Yoshito Ikeda, Tetsuya Minegaki, Shin-ya Morita, Tomohiro Terada and Kohshi Nishiguchi

Drug Metabolism and Disposition April 2021, 49 (4) 289-297; DOI: https://doi.org/10.1124/dmd.120.000126
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Functional Proliferating Human Hepatocytes: In Vitro Hepatocyte Model for Drug Metabolism, Excretion, and Toxicity
Shida Qiao, Sisi Feng, Zhitao Wu, Ting He, Chen Ma, Zhaoliang Peng, E. Tian and Guoyu Pan

Drug Metabolism and Disposition April 2021, 49 (4) 305-313; DOI: https://doi.org/10.1124/dmd.120.000275

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