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Generation and Characterization of Cytochrome P450 2J3/10 CRISPR/Cas9 Knockout Rat Model
Jian Lu, Ang Chen, Xinrun Ma, Xuyang Shang, Yuanjin Zhang, Yuanqing Guo, Mingyao Liu and Xin Wang

Drug Metabolism and Disposition November 2020, 48 (11) 1129-1136; DOI: https://doi.org/10.1124/dmd.120.000114
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Differences in metformin and thiamine uptake between human and mouse organic cation transporter OCT1: structural determinants and potential consequences for intrahepatic concentrations
Marleen J. Meyer, Alzbeta Tuerkova, Sarah Römer, Christoph Wenzel, Tina Seitz, Jochen Gaedcke, Stefan Oswald, Jurgen Brockmöller, Barbara Zdrazil and Mladen V. Tzvetkov

Drug Metabolism and Disposition October 9, 2020, DMD-AR-2020-000170; DOI: https://doi.org/10.1124/dmd.120.000170
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In Vitro Hepatic Uptake in Human and Monkey Hepatocytes in the Presence and Absence of Serum Protein and Its In vitro to In vivo Extrapolation
Xiaomin Liang, Yeojin Park, Natalie DeForest, Jia Hao, Xiaofeng Zhao, Congrong Niu, Kelly Wang, Bill J Smith and Yurong Lai

Drug Metabolism and Disposition October 9, 2020, DMD-AR-2020-000163; DOI: https://doi.org/10.1124/dmd.120.000163
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Calibrating the in vitro-in vivo correlation for OATP mediated drug-drug interactions with rosuvastatin using static and PBPK models
Rucha Sane, Kit Wun Kathy Cheung, Péter Kovács, Taleah Farasyn, Ruina Li, Annamaria Bui, Luna Musib, Emese Kis, Emile Plise and Zsuzsanna Gáborik

Drug Metabolism and Disposition October 9, 2020, DMD-AR-2020-000149; DOI: https://doi.org/10.1124/dmd.120.000149
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Site Directed Mutagenesis at the MoCo Site of the Human Aldehyde Oxidase: Interrogating the Kinetic Differences Between Human and Cynomolgus Monkey
Armina Abbasi, Carolyn A. Joswig-Jones and Jeffrey P. Jones

Drug Metabolism and Disposition October 8, 2020, DMD-AR-2020-000187; DOI: https://doi.org/10.1124/dmd.120.000187
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A multi compartment human kidney proximal tubule-on-a-chip replicates cell polarization-dependent cisplatin toxicity
Tom T.G. Nieskens, Mikael Persson, Edward J. Kelly and Anna-Karin Sjögren

Drug Metabolism and Disposition October 5, 2020, DMD-AR-2020-000098; DOI: https://doi.org/10.1124/dmd.120.000098
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Cell type-specific roles of CD38 in the interactions of isoniazid with NAD⁺ in the liver
Junjie Zhu, Jie Lu, Hung-Chun Tung, Ke Liu, Jianhua Li, Denis M. Grant, Wen Xie and Xiaochao Ma

Drug Metabolism and Disposition October 5, 2020, DMD-AR-2020-000139; DOI: https://doi.org/10.1124/dmd.120.000139
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In Vitro Characterization of Ertugliflozin Metabolism by UDP-Glucuronosyltransferase and Cytochrome P450 Enzymes
Kimberly Lapham, Ernesto Callegari, Julie Cianfrogna, Jian Lin, Mark Niosi, Christine C. Orozco, Raman Sharma and Theunis C. Goosen

Drug Metabolism and Disposition October 5, 2020, DMD-AR-2020-000171; DOI: https://doi.org/10.1124/dmd.120.000171
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Anti-Ly6E-seco-CBI-Dimer Antibody-Drug Conjugate (ADC) That Forms Adduct with Alpha-1-microglobulin (A1M) Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals
Victor Yip, Isabel Figueroa, Brandon Latifi, Shab Masih, Carl Ng, Doug Leipold, Amrita Kamath and Ben-Quan Shen

Drug Metabolism and Disposition October 5, 2020, DMD-AR-2020-000145; DOI: https://doi.org/10.1124/dmd.120.000145
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In vitro investigation, pharmacokinetics and disposition of imeglimin, a novel oral antidiabetic drug, in preclinical species and humans
Clémence Chevalier, Pascale Fouqueray and Sebastien Bolze

Drug Metabolism and Disposition October 5, 2020, DMD-AR-2020-000154; DOI: https://doi.org/10.1124/dmd.120.000154

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