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Oleuropein-induced acceleration of CYP-catalyzed drug metabolism: central role for nuclear receptor PPARα
Foteini Malliou, Christina E. Andriopoulou, Frank J. Gonzalez, Aristeidis Kofinas, Alexios-Leandros Skaltsounis and Maria Konstandi

Drug Metabolism and Disposition June 23, 2021, DMD-AR-2020-000302; DOI: https://doi.org/10.1124/dmd.120.000302
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MicroRNAs in apple-derived nanoparticles modulate intestinal expression of OATP2B1/SLCO2B1 in Caco-2 cells
Hisakazu Komori, Daichi Fujita, Yuma Shirasaki, Qiunan Zhu, Yui Iwamoto, Takeo Nakanishi, Miki Nakajima and Ikumi Tamai

Drug Metabolism and Disposition June 23, 2021, DMD-AR-2021-000380; DOI: https://doi.org/10.1124/dmd.121.000380
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Leveraging Physiologically-Based Pharmacokinetic (PBPK) Modeling and Experimental Data to Guide Dosing Modification of CYP3A-Mediated Drug-Drug Interactions (DDIs) in the Pediatric Population
Sara N. Salerno, Fernando O. Carreño, Andrea N. Edginton, Michael Cohen-Wolkowiez and Daniel Gonzalez

Drug Metabolism and Disposition June 21, 2021, DMD-AR-2020-000318; DOI: https://doi.org/10.1124/dmd.120.000318
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Impact of inter-individual differences in plasma fraction unbound on the pharmacokinetics of a novel Syk kinase inhibitor in Beagle dogs
Andy Pike, Barry Jones, Roshini Markandu and Daniel O'Neill

Drug Metabolism and Disposition June 16, 2021, DMD-AR-2021-000409; DOI: https://doi.org/10.1124/dmd.121.000409
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Messenger RNA expression of albumin, transferrin, transthyretin, asialoglycoprotein receptor, P450 isoform, uptake transporter and efflux transporter genes as a function of culture duration in prolonged cultured cryopreserved human hepatocytes from 7 donors as collagen-matrigel sandwich cultures: Evidence for redifferentiation upon prolonged culturing
Qian Yang and Albert P. Li

Drug Metabolism and Disposition June 16, 2021, DMD-AR-2021-000424; DOI: https://doi.org/10.1124/dmd.121.000424
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Differences in hydrolase activities in the liver and small intestine between marmosets and humans
Shiori Honda, Tatsuki Fukami, Keiya Hirosawa, Takuya Tsujiguchi, Yongjie Zhang, Masataka Nakano, Shotaro Uehara, Yasuhiro Uno, Hiroshi Yamazaki and Miki Nakajima

Drug Metabolism and Disposition June 16, 2021, DMD-AR-2021-000513; DOI: https://doi.org/10.1124/dmd.121.000513
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In Vivo–to–In Vitro Extrapolation of Transporter-Mediated Renal Clearance: Relative Expression Factor Versus Relative Activity Factor Approach
Aditya R. Kumar, Bhagwat Prasad, Deepak Kumar Bhatt, Sumathy Mathialagan, Manthena V. S. Varma and Jashvant D. Unadkat

Drug Metabolism and Disposition June 2021, 49 (6) 470-478; DOI: https://doi.org/10.1124/dmd.121.000367
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Reversible and Irreversible Inhibition of Cytochrome P450 Enzymes by Methylophiopogonanone A
Dong-Zhu Tu, Xu Mao, Feng Zhang, Rong-Jing He, Jing-Jing Wu, Yue Wu, Xiao-Hua Zhao, Jiang Zheng and Guang-Bo Ge

Drug Metabolism and Disposition June 2021, 49 (6) 459-469; DOI: https://doi.org/10.1124/dmd.120.000325
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Pharmacokinetic and Biochemical Profiling of Sodium Dichloroacetate in Pregnant Ewes and Fetuses
Serene Joseph, Abhisheak Sharma, Lloyd P. Horne, Charles E. Wood, Taimour Langaee, Margaret O. James, Peter W. Stacpoole and Maureen Keller-Wood

Drug Metabolism and Disposition June 2021, 49 (6) 451-458; DOI: https://doi.org/10.1124/dmd.120.000330
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Cytochrome P450 3A Time-Dependent Inhibition Assays Are Too Sensitive for Identification of Drugs Causing Clinically Significant Drug-Drug Interactions: A Comparison of Human Liver Microsomes and Hepatocytes and Definition of Boundaries for Inactivation Rate Constants
Heather Eng, Elaine Tseng, Matthew A. Cerny, Theunis C. Goosen and R. Scott Obach

Drug Metabolism and Disposition June 2021, 49 (6) 442-450; DOI: https://doi.org/10.1124/dmd.121.000356

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