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Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics
Mary Alexandra Schleiff, Noah R. Flynn, Sasin Payakachat, Benjamin Mark Schleiff, Anna O. Pinson, Dennis W. Province, S. Joshua Swamidass, Gunnar Boysen and Grover P. Miller

Drug Metabolism and Disposition February 2021, 49 (2) 133-141; DOI: https://doi.org/10.1124/dmd.120.000254
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In Vitro Metabolism of Slowly Cleared G Protein–Coupled Receptor 139 Agonist TAK-041 Using Rat, Dog, Monkey, and Human Hepatocyte Models (HepatoPac): Correlation with In Vivo Metabolism
Amin Kamel, Steve Bowlin, Natalie Hosea, Dimitrios Arkilo and Antonio Laurenza

Drug Metabolism and Disposition February 2021, 49 (2) 121-132; DOI: https://doi.org/10.1124/dmd.120.000246
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Predicting Volume of Distribution in Humans: Performance of In Silico Methods for a Large Set of Structurally Diverse Clinical Compounds
Neha Murad, Kishore K. Pasikanti, Benjamin D. Madej, Amanda Minnich, Juliet M. McComas, Sabrinia Crouch, Joseph W. Polli and Andrew D. Weber

Drug Metabolism and Disposition February 2021, 49 (2) 169-178; DOI: https://doi.org/10.1124/dmd.120.000202
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Function and Expression of Bile Salt Export Pump in Suspension Human Hepatocytes
Paresh P. Chothe, Rachel Pemberton and Niresh Hariparsad

Drug Metabolism and Disposition January 20, 2021, DMD-AR-2020-000057; DOI: https://doi.org/10.1124/dmd.120.000057
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In vitro evidence of potential interactions between CYP2C8 and candesartan acyl-β-D-glucuronide in the liver
Yurie Katsube, Masayuki Tsujimoto, Hiroyoshi Koide, Daiki Hira, Yoshito Ikeda, Tetsuya Minegaki, Shin-ya Morita, Tomohiro Terada and Kohshi Nishiguchi

Drug Metabolism and Disposition January 14, 2021, DMD-AR-2020-000126; DOI: https://doi.org/10.1124/dmd.120.000126
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Role of human AADAC on hydrolysis of eslicarbazepine acetate and effects of AADAC genetic polymorphisms on hydrolase activity
Keiya Hirosawa, Tatsuki Fukami, Kiyomichi Tashiro, Yoshiyuki Sakai, Fumiya Kisui, Masataka Nakano and Miki Nakajima

Drug Metabolism and Disposition January 14, 2021, DMD-AR-2020-000295; DOI: https://doi.org/10.1124/dmd.120.000295
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Correction to “Investigating the Role of Altered Systemic Albumin Concentration on the Disposition of Theophylline in Adult and Pediatric Patients with Asthma by Using the Physiologically Based Pharmacokinetic Approach”
Drug Metabolism and Disposition January 2021, 49 (1) 120; DOI: https://doi.org/10.1124/dmd.120.090969err
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Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment
Simon G. Wong, Diane Ramsden, Shannon Dallas, Conrad Fung, Heidi J. Einolf, Jairam Palamanda, Liangfu Chen, Theunis C. Goosen, Y. Amy Siu, George Zhang, Donald Tweedie, Niresh Hariparsad, Barry Jones and Phillip D. Yates

Drug Metabolism and Disposition January 2021, 49 (1) 94-110; DOI: https://doi.org/10.1124/dmd.120.000055
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Sex-, Age-, and Race/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers
Jie Liu, Julia Yue Cui, Yuan-Fu Lu, J. Christopher Corton and Curtis D. Klaassen

Drug Metabolism and Disposition January 2021, 49 (1) 111-119; DOI: https://doi.org/10.1124/dmd.120.000181
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Effect of Human Plasma on Hepatic Uptake of Organic Anion–Transporting Polypeptide 1B Substrates: Studies Using Transfected Cells and Primary Human Hepatocytes
Yi-an Bi, Sangwoo Ryu, David A. Tess, A. David Rodrigues and Manthena V. S. Varma

Drug Metabolism and Disposition January 2021, 49 (1) 72-83; DOI: https://doi.org/10.1124/dmd.120.000134

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