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Comparative hepatic and intestinal metabolism and pharmacodynamics of statins
Anne M. Filppula, Päivi Hirvensalo, Heli Parviainen, Vilma E. Ivaska, K. Ivar Lönnberg, Feng Deng, Jenni Viinamäki, Mika Kurkela, Mikko Neuvonen and Mikko Niemi

Drug Metabolism and Disposition May 27, 2021, DMD-AR-2021-000406; DOI: https://doi.org/10.1124/dmd.121.000406
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Proteomic Quantification of Changes in Abundance of Drug-Metabolizing Enzymes and Drug Transporters in Human Liver Cirrhosis: Different Methods, Similar Outcomes
Eman El-Khateeb, Zubida M. Al-Majdoub, Amin Rostami-Hodjegan, Jill Barber and Brahim Achour

Drug Metabolism and Disposition May 27, 2021, DMD-AR-2021-000484; DOI: https://doi.org/10.1124/dmd.121.000484
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3,3'-Diindolylmethane (BioResponse DIM^®) Exhibits Significant Metabolism Following Oral Dosing in Humans
Monica L. Vermillion Maier, Lisbeth K. Siddens, Sandra L. Uesugi, Jaewoo Choi, Scott W. Leonard, Jamie M. Pennington, Susan C. Tilton, Jordan N. Smith, Emily Ho, H.H. Sherry Chow, Bach D. Nguyen, Siva K. Kolluri and David E. Williams

Drug Metabolism and Disposition May 25, 2021, DMD-AR-2020-000346; DOI: https://doi.org/10.1124/dmd.120.000346
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Deconvolution of CYP Induction Mechanisms in HepaRG Nuclear Hormone Receptor Knockout Cells
Lena C. Preiss, Ruoqi Liu, Philip Hewitt, David Thompson, Katrin Georgi, Lassina Badolo, Volker M. Lauschke and Carl Petersson

Drug Metabolism and Disposition May 25, 2021, DMD-AR-2020-000333; DOI: https://doi.org/10.1124/dmd.120.000333
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Passive influx and ion trapping are more relevant to the cellular accumulation of highly permeable low molecular weight acidic drugs than is Organic Anion Transporter 2 (OAT2)
Dallas Bednarczyk

Drug Metabolism and Disposition May 24, 2021, DMD-AR-2021-000425; DOI: https://doi.org/10.1124/dmd.121.000425
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Investigation into MAO B-mediated formation of CC112273, a major circulating metabolite of ozanimod, in humans and preclinical species: Stereospecific oxidative deamination of (S)-enantiomer of indaneamine (RP101075) by MAO B
April Bai, Veerabahu .Shanmugasundaram, Julie V. Selkirk, Sekhar Surapaneni and Deepak Dalvie

Drug Metabolism and Disposition May 19, 2021, DMD-AR-2021-000447; DOI: https://doi.org/10.1124/dmd.121.000447
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Negative Regulation of Human Hepatic Constitutive Androstane Receptor by Cholesterol Synthesis Inhibition: Role of Sterol Regulatory Element Binding Proteins
Liberta Cuko, Zofia Duniec-Dmuchowski, Elizabeth A. Rondini, Asmita Pant, John K. Fallon, Elizabeth M. Wilson, Nicholas J. Peraino, Judy A. Westrick, Philip C. Smith and Thomas A. Kocarek

Drug Metabolism and Disposition May 19, 2021, DMD-AR-2020-000341; DOI: https://doi.org/10.1124/dmd.120.000341
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Pharmacokinetics, disposition, and biotransformation of [¹⁴C]-omecamtiv mecarbil in healthy male subjects after a single intravenous or oral dose.
Ashit Trivedi, Jan Wahlstrom, Mia Mackowski, Sandeep Dutta and Edward Lee

Drug Metabolism and Disposition May 19, 2021, DMD-AR-2021-000444; DOI: https://doi.org/10.1124/dmd.121.000444
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Metabolism and Mass Balance of the Novel Nonsteroidal Androgen Receptor Inhibitor Darolutamide in Humans
Päivi Taavitsainen, Olaf Prien, Marja Kähkönen, Michael Niehues, Timo Korjamo, Karsten Denner, Pirjo Nykänen, Annamari Vuorela, Natalia A. Jungmann, Clemens-Jeremias von Bühler, Mikko Koskinen, Christian Zurth and Hille Gieschen

Drug Metabolism and Disposition June 2021, 49 (6) 420-433; DOI: https://doi.org/10.1124/dmd.120.000309
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Dual Action of Acidic Microenvironment on the Enrichment of the Active Metabolite of Disulfiram in Tumor Tissues
Chongzhuang Tang, Xiaoyan Pang, Zitao Guo, Runcong Guo, Lu Liu and Xiaoyan Chen

Drug Metabolism and Disposition June 2021, 49 (6) 434-441; DOI: https://doi.org/10.1124/dmd.120.000317

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