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Quantification of Neonatal Fc Receptor and Beta-2 Microglobulin in Human Liver Tissues by Ultraperformance Liquid Chromatography–Multiple Reaction Monitoring–based Targeted Quantitative Proteomics for Applications in Biotherapeutic Physiologically-based Pharmacokinetic Models
Xiazi Qiu and Michael Zhuo Wang

Drug Metabolism and Disposition October 2020, 48 (10) 925-933; DOI: https://doi.org/10.1124/dmd.120.000075
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Prediction of Human Disproportionate and Biliary Excreted Metabolites Using Chimeric Mice with Humanized Liver
Suguru Kato, Abhi Shah, Mihaela Plesescu, Yoshinari Miyata, Jayaprakasam Bolleddula, Swapan Chowdhury and Xiaochun Zhu

Drug Metabolism and Disposition October 2020, 48 (10) 934-943; DOI: https://doi.org/10.1124/dmd.120.000128
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Absorption, Distribution, Metabolism, and Excretion of Capmatinib (INC280) in Healthy Male Volunteers and In Vitro Aldehyde Oxidase Phenotyping of the Major Metabolite
Ulrike Glaenzel, Yi Jin, Regine Hansen, Kirsten Schroer, Gholamreza Rahmanzadeh, Ulrike Pfaar, Jan Jaap van Lier, Hubert Borell, Axel Meissner, Gian Camenisch and Sylvia Zhao

Drug Metabolism and Disposition October 2020, 48 (10) 873-885; DOI: https://doi.org/10.1124/dmd.119.090324
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Application of the Extended Clearance Classification System (ECCS) in Drug Discovery and Development: Selection of Appropriate In Vitro Tools and Clearance Prediction
Kenichi Umehara, Carina Cantrill, Matthias Beat Wittwer, Elisa Di Lenarda, Florian Klammers, Aynur Ekiciler, Neil Parrott, Stephen Fowler and Mohammed Ullah

Drug Metabolism and Disposition October 2020, 48 (10) 849-860; DOI: https://doi.org/10.1124/dmd.120.000133
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A Study of the Effect of Cyclosporine on Fevipiprant Pharmacokinetics and its Absolute Bioavailability Using an Intravenous Microdose Approach
H. Markus Weiss, Ken-Ichi Umehara, Veit J. Erpenbeck, Meredith Cain, Janardhana Vemula, Walid Elbast and Markus Zollinger

Drug Metabolism and Disposition October 2020, 48 (10) 917-924; DOI: https://doi.org/10.1124/dmd.120.090852
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Detection of Weak Organic Anion–Transporting Polypeptide 1B Inhibition by Probenecid with Plasma-Based Coproporphyrin in Humans
Yueping Zhang, Vinay K. Holenarsipur, Hamza Kandoussi, Jianing Zeng, T. Thanga Mariappan, Michael Sinz and Hong Shen

Drug Metabolism and Disposition October 2020, 48 (10) 841-848; DOI: https://doi.org/10.1124/dmd.120.000076
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Comparison of In Vitro to In Vivo Extrapolation Approaches for Predicting Transporter-Mediated Hepatic Uptake Clearance Using Suspended Rat Hepatocytes
Na Li, Akshay Badrinarayanan, Xingwen Li, John Roberts, Mike Hayashi, Manpreet Virk and Anshul Gupta

Drug Metabolism and Disposition October 2020, 48 (10) 861-872; DOI: https://doi.org/10.1124/dmd.120.000064
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Seeking Nonspecific Binding: Assessing the Reliability of Tissue Dilutions for Calculating Fraction Unbound
William J. Jusko, Emilie A.G. Molins and Vivaswath S. Ayyar

Drug Metabolism and Disposition October 2020, 48 (10) 894-902; DOI: https://doi.org/10.1124/dmd.120.000118
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Preclinical Transplacental Transfer and Pharmacokinetics of Fipronil in Rats
Ya-Ning Chang and Tung-Hu Tsai

Drug Metabolism and Disposition October 2020, 48 (10) 886-893; DOI: https://doi.org/10.1124/dmd.120.000088
Open Access
Quantification of the Impact of Partition Coefficient Prediction Methods on Physiologically Based Pharmacokinetic Model Output Using a Standardized Tissue Composition
Kiersten Utsey, Madeleine S. Gastonguay, Sean Russell, Reed Freling, Matthew M. Riggs and Ahmed Elmokadem

Drug Metabolism and Disposition October 2020, 48 (10) 903-916; DOI: https://doi.org/10.1124/dmd.120.090498

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