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Absorption, Metabolism, and Excretion, In Vitro Pharmacology, and Clinical Pharmacokinetics of Ozanimod, a Novel Sphingosine 1-Phosphate Receptor Modulator
Sekhar Surapaneni, Usha Yerramilli, April Bai, Deepak Dalvie, Jennifer Brooks, Xiaomin Wang, Julie V. Selkirk, Yingzhuo Grace Yan, Peijin Zhang, Richard Hargreaves, Gondi Kumar, Maria Palmisano and Jonathan Q. Tran

Drug Metabolism and Disposition May 2021, 49 (5) 405-419; DOI: https://doi.org/10.1124/dmd.120.000220
Open Access
SLCO1B1: Application and Limitations of Deep Mutational Scanning for Genomic Missense Variant Function
Lingxin Zhang, Vivekananda Sarangi, Ming-Fen Ho, Irene Moon, Krishna R. Kalari, Liewei Wang and Richard M. Weinshilboum

Drug Metabolism and Disposition May 2021, 49 (5) 395-404; DOI: https://doi.org/10.1124/dmd.120.000264
Open Access
Clinical Investigation of Metabolic and Renal Clearance Pathways Contributing to the Elimination of Fevipiprant Using Probenecid as Perpetrator
H. Markus Weiss, Thomas Langenickel, Meredith Cain, Swarupa Kulkarni, Bharti Shah, Janardhana Vemula, Gholamreza Rahmanzadeh and Birk Poller

Drug Metabolism and Disposition May 2021, 49 (5) 389-394; DOI: https://doi.org/10.1124/dmd.120.000273
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Metabolic Retroversion of Piperaquine (PQ) via Hepatic Cytochrome P450–Mediated N-Oxidation and Reduction: Not an Important Contributor to the Prolonged Elimination of PQ
Yuewu Xie, Yunrui Zhang, Huixiang Liu and Jie Xing

Drug Metabolism and Disposition May 2021, 49 (5) 379-388; DOI: https://doi.org/10.1124/dmd.120.000306
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Tertiary Oxidation of Deoxycholate Is Predictive of CYP3A Activity in Dogs
Wushuang Zeng, Lanlan Gui, Xianwen Tan, Pingping Zhu, Yiting Hu, Qingliang Wu, Xuejing Li, Lian Yang, Wei Jia, Changxiao Liu and Ke Lan

Drug Metabolism and Disposition May 2021, 49 (5) 369-378; DOI: https://doi.org/10.1124/dmd.121.000385
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The Long Noncoding RNA Hepatocyte Nuclear Factor 4α Antisense RNA 1 Negatively Regulates Cytochrome P450 Enzymes in Huh7 Cells via Histone Modifications
Pei Wang, Shitong Chen, Yiting Wang, Xiaofei Wang, Liang Yan, Kun Yang, Xiao-bo Zhong, Shengna Han and Lirong Zhang

Drug Metabolism and Disposition May 2021, 49 (5) 361-368; DOI: https://doi.org/10.1124/dmd.120.000316
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Identification of Triterpene Acids in Poria cocos Extract as Bile Acid Uptake Transporter Inhibitors
Hui Cai, Yujie Cheng, Qiunan Zhu, Dexuan Kong, Xijing Chen, Ikumi Tamai and Yang Lu

Drug Metabolism and Disposition May 2021, 49 (5) 353-360; DOI: https://doi.org/10.1124/dmd.120.000308
Open Access
In Vivo Functional Effects of CYP2C9 M1L, a Novel and Common Variant in the Yup’ik Alaska Native Population
Lindsay M. Henderson, Scarlett E. Hopkins, Bert B. Boyer, Timothy A. Thornton, Allan E. Rettie and Kenneth E. Thummel

Drug Metabolism and Disposition May 2021, 49 (5) 345-352; DOI: https://doi.org/10.1124/dmd.120.000301
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Role of Human Arylacetamide Deacetylase (AADAC) on Hydrolysis of Eslicarbazepine Acetate and Effects of AADAC Genetic Polymorphisms on Hydrolase Activity
Keiya Hirosawa, Tatsuki Fukami, Kiyomichi Tashiro, Yoshiyuki Sakai, Fumiya Kisui, Masataka Nakano and Miki Nakajima

Drug Metabolism and Disposition April 2021, 49 (4) 322-329; DOI: https://doi.org/10.1124/dmd.120.000295
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Correction to “Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro CYP Induction Studies Including Impact on Drug Interaction Risk Assessment”
Drug Metabolism and Disposition April 2021, 49 (4) 344; DOI: https://doi.org/10.1124/dmd.120.000055err

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