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Development of a Pharmacokinetic Model of Transplacental Transfer of Metformin to Predict In Vivo Fetal Exposure
Ken Kurosawa, Koji Chiba, Saki Noguchi, Tomohiro Nishimura and Masatoshi Tomi

Drug Metabolism and Disposition December 2020, 48 (12) 1293-1302; DOI: https://doi.org/10.1124/dmd.120.000127
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A Multicompartment Human Kidney Proximal Tubule-on-a-Chip Replicates Cell Polarization–Dependent Cisplatin Toxicity
Tom T.G. Nieskens, Mikael Persson, Edward J. Kelly and Anna-Karin Sjögren

Drug Metabolism and Disposition December 2020, 48 (12) 1303-1311; DOI: https://doi.org/10.1124/dmd.120.000098
Open Access
Calibrating the In Vitro–In Vivo Correlation for OATP-Mediated Drug-Drug Interactions with Rosuvastatin Using Static and PBPK Models
Rucha Sane, Kit Wun Kathy Cheung, Péter Kovács, Taleah Farasyn, Ruina Li, Annamaria Bui, Luna Musib, Emese Kis, Emile Plise and Zsuzsanna Gáborik

Drug Metabolism and Disposition December 2020, 48 (12) 1264-1270; DOI: https://doi.org/10.1124/dmd.120.000149
Open Access
Anti–Lymphocyte Antigen 6 Complex, Locus E-Seco-Cyclopropabenzindol-4-One-Dimer Antibody-Drug Conjugate That Forms Adduct with α1-Microglobulin Demonstrates Slower Systemic Antibody Clearance and Reduced Tumor Distribution in Animals
Victor Yip, Isabel Figueroa, Brandon Latifi, Shab Masih, Carl Ng, Doug Leipold, Amrita Kamath and Ben-Quan Shen

Drug Metabolism and Disposition December 2020, 48 (12) 1247-1256; DOI: https://doi.org/10.1124/dmd.120.000145
Open Access
Pharmacokinetic and Pharmacodynamic Factors Contribute to Synergism between Let-7c-5p and 5-Fluorouracil in Inhibiting Hepatocellular Carcinoma Cell Viability
Joseph L. Jilek, Mei-Juan Tu, Chao Zhang and Ai-Ming Yu

Drug Metabolism and Disposition December 2020, 48 (12) 1257-1263; DOI: https://doi.org/10.1124/dmd.120.000207
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Correction to “Carboxylesterase 1 and Precision Pharmacotherapy: Pharmacogenetics and Nongenetic Regulators”
Drug Metabolism and Disposition November 2020, 48 (11) 1246; DOI: https://doi.org/10.1124/dmd.119.089680err
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Pharmacokinetics and Catabolism of [³H]TAK-164, a Guanylyl Cyclase C Targeted Antibody-Drug Conjugate
Jayaprakasam Bolleddula, Abhi Shah, Mohammad Shadid, Afrand Kamali, Michael D. Smith and Swapan K. Chowdhury

Drug Metabolism and Disposition November 2020, 48 (11) 1239-1245; DOI: https://doi.org/10.1124/dmd.120.000194
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A Laboratory-Specific Scaling Factor to Predict the In Vivo Human Clearance of Aldehyde Oxidase Substrates
Mailys De Sousa Mendes, Alexandra L. Orton, Helen E. Humphries, Barry Jones, Iain Gardner, Sibylle Neuhoff and Venkatesh Pilla Reddy

Drug Metabolism and Disposition November 2020, 48 (11) 1231-1238; DOI: https://doi.org/10.1124/dmd.120.000082
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Exposure of Rats to Multiple Oral Doses of Dichloroacetate Results in Upregulation of Hepatic Glutathione Transferases and NAD(P)H Dehydrogenase [Quinone] 1
Edwin J. Squirewell, Ricky Mareus, Lloyd P. Horne, Peter W. Stacpoole and Margaret O. James

Drug Metabolism and Disposition November 2020, 48 (11) 1224-1230; DOI: https://doi.org/10.1124/dmd.120.000143
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Functional Consequences of Pravastatin Isomerization on OATP1B1-Mediated Transport
Jonathan B. Wagner, Melissa Ruggiero, J. Steven Leeder and Bruno Hagenbuch

Drug Metabolism and Disposition November 2020, 48 (11) 1192-1198; DOI: https://doi.org/10.1124/dmd.120.000122

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