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Prediction of Transporter-Mediated Drug-Drug Interactions and Phenotyping of Hepatobiliary Transporters Involved in the Clearance of E7766, a Novel Macrocycle-Bridged Dinucleotide
Rongrong Jiang, Andrew Hart, Laurette Burgess, Dae-Shik Kim, Weidong George Lai and Vaishali Dixit

Drug Metabolism and Disposition March 2021, 49 (3) 265-275; DOI: https://doi.org/10.1124/dmd.120.000125
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Evaluation of the Utility of PXB Chimeric Mice for Predicting Human Liver Partitioning of Hepatic Organic Anion-Transporting Polypeptide Transporter Substrates
Bo Feng, Rachel Pemberton, Wojciech Dworakowski, Zhengqi Ye, Craig Zetterberg, Guanyu Wang, Yoshio Morikawa and Sanjeev Kumar

Drug Metabolism and Disposition March 2021, 49 (3) 254-264; DOI: https://doi.org/10.1124/dmd.120.000276
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Evaluation of Tissue Stem Cell–Derived Human Intestinal Organoids, a Physiologically Relevant Model to Evaluate Cytochrome P450 Induction in Gut
David M. Stresser, Jun Sun and Sarah S. Wilson

Drug Metabolism and Disposition March 2021, 49 (3) 245-253; DOI: https://doi.org/10.1124/dmd.120.000281
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The Hypoglycemic Effect of Berberine and Berberrubine Involves Modulation of Intestinal Farnesoid X Receptor Signaling Pathway and Inhibition of Hepatic Gluconeogenesis
Runbin Sun, Bo Kong, Na Yang, Bei Cao, Dong Feng, Xiaoyi Yu, Chun Ge, Siqi Feng, Fei Fei, Jingqiu Huang, Zhenyao Lu, Yuan Xie, Chung S. Yang, Grace L. Guo, Guangji Wang and Jiye Aa

Drug Metabolism and Disposition March 2021, 49 (3) 276-286; DOI: https://doi.org/10.1124/dmd.120.000215
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Functional Characterization of 40 CYP3A4 Variants by Assessing Midazolam 1′-Hydroxylation and Testosterone 6β-Hydroxylation
Masaki Kumondai, Evelyn Marie Gutiérrez Rico, Eiji Hishinuma, Akiko Ueda, Sakae Saito, Daisuke Saigusa, Shu Tadaka, Kengo Kinoshita, Tomoki Nakayoshi, Akifumi Oda, Ai Abe, Masamitsu Maekawa, Nariyasu Mano, Noriyasu Hirasawa and Masahiro Hiratsuka

Drug Metabolism and Disposition March 2021, 49 (3) 212-220; DOI: https://doi.org/10.1124/dmd.120.000261
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Impact of Plasma Protein Binding in Drug Clearance Prediction: A Database Analysis of Published Studies and Implications for In Vitro-In Vivo Extrapolation
L. J. Francis, J. B. Houston and D. Hallifax

Drug Metabolism and Disposition March 2021, 49 (3) 188-201; DOI: https://doi.org/10.1124/dmd.120.000294
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In Vivo Gene Expression Profile of Human Intestinal Epithelial Cells: From the Viewpoint of Drug Metabolism and Pharmacokinetics
Kazuo Takayama, Kohei Ito, Akiko Matsui, Tomoki Yamashita, Kentaro Kawakami, Daisuke Hirayama, Wataru Kishimoto, Hiroshi Nakase and Hiroyuki Mizuguchi

Drug Metabolism and Disposition March 2021, 49 (3) 221-232; DOI: https://doi.org/10.1124/dmd.120.000283
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Detoxication versus Bioactivation Pathways of Lapatinib In Vitro: UGT1A1 Catalyzes the Hepatic Glucuronidation of Debenzylated Lapatinib
Dasean T. Nardone-White, Jennifer E. Bissada, Arsany A. Abouda and Klarissa D. Jackson

Drug Metabolism and Disposition March 2021, 49 (3) 233-244; DOI: https://doi.org/10.1124/dmd.120.000236
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Tryptophan-75 Is a Low-Energy Channel-Gating Residue that Facilitates Substrate Egress/Access in Cytochrome P450 2D6
Kevin D. McCarty, Samuel A. Ratliff, Kyle A. Furge and Laura Lowe Furge

Drug Metabolism and Disposition March 2021, 49 (3) 179-187; DOI: https://doi.org/10.1124/dmd.120.000274
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Aldehyde Oxidase Contributes to All-Trans-Retinoic Acid Biosynthesis in Human Liver
Guo Zhong, Chris J. Seaman, Erickson M. Paragas, Huaqing Xi, Karla-Luise Herpoldt, Neil P. King, Jeffrey P. Jones and Nina Isoherranen

Drug Metabolism and Disposition March 2021, 49 (3) 202-211; DOI: https://doi.org/10.1124/dmd.120.000296

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