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Drug Metabolism & Disposition

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Latest Articles

  • (–)-<em>N</em>-3-Benzylphenobarbital Is Superior to Omeprazole and (+)-<em>N</em>-3-Benzylnirvanol as a CYP2C19 Inhibitor in Suspended Human Hepatocytes
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    (–)-N-3-Benzylphenobarbital Is Superior to Omeprazole and (+)-N-3-Benzylnirvanol as a CYP2C19 Inhibitor in Suspended Human Hepatocytes
    Marie-Lynn Cuypers, Hugues Chanteux, Eric Gillent, Pierre Bonnaillie, Kenneth Saunders, Claire Beckers, Claude Delatour, Sylvie Dell’Aiera, Anna-Lena Ungell and Johan Nicolaï
    Drug Metabolism and Disposition November 2020, 48 (11) 1121-1128; DOI: https://doi.org/10.1124/dmd.120.000089
  • Generation and Characterization of Cytochrome P450 2J3/10 CRISPR/Cas9 Knockout Rat Model
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    Generation and Characterization of Cytochrome P450 2J3/10 CRISPR/Cas9 Knockout Rat Model
    Jian Lu, Ang Chen, Xinrun Ma, Xuyang Shang, Yuanjin Zhang, Yuanqing Guo, Mingyao Liu and Xin Wang
    Drug Metabolism and Disposition November 2020, 48 (11) 1129-1136; DOI: https://doi.org/10.1124/dmd.120.000114
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    Effects of Chrysin and Its Major Conjugated Metabolites Chrysin-7-Sulfate and Chrysin-7-Glucuronide on Cytochrome P450 Enzymes and on OATP, P-gp, BCRP, and MRP2 Transporters
    Violetta Mohos, Eszter Fliszár-Nyúl, Orsolya Ungvári, Éva Bakos, Katalin Kuffa, Tímea Bencsik, Balázs Zoltán Zsidó, Csaba Hetényi, Ágnes Telbisz, Csilla Özvegy-Laczka and Miklós Poór
    Drug Metabolism and Disposition October 2020, 48 (10) 1064-1073; DOI: https://doi.org/10.1124/dmd.120.000085
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    Influence of Zuojin Pill on the Metabolism of Venlafaxine in Vitro and in Rats and Associated Herb-Drug Interaction
    Yue Li, Juan Li, Dongmin Yan, Qian Wang, Jingyi Jin, Bo Tan and Furong Qiu
    Drug Metabolism and Disposition October 2020, 48 (10) 1044-1052; DOI: https://doi.org/10.1124/dmd.120.000048
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    National Center for Complementary and Integrative Health Perspectives on Clinical Research Involving Natural Products
    Wendy J. Weber and D. Craig Hopp
    Drug Metabolism and Disposition October 2020, 48 (10) 963-965; DOI: https://doi.org/10.1124/dmd.120.000071
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    Mechanisms of Herb-Drug Interactions Involving Cinnamon and CYP2A6: Focus on Time-Dependent Inhibition by Cinnamaldehyde and 2-Methoxycinnamaldehyde
    Michael J. Espiritu, Justin Chen, Jaydeep Yadav, Michael Larkin, Robert D. Pelletier, Jeannine M. Chan, Jeevan B. GC, Senthil Natesan and John P. Harrelson
    Drug Metabolism and Disposition October 2020, 48 (10) 1028-1043; DOI: https://doi.org/10.1124/dmd.120.000087
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    Centella asiatica Water Extract Shows Low Potential for Cytochrome P450–Mediated Drug Interactions
    Kirsten M. Wright, Armando Alcazar Magana, Ronald M. Laethem, Caroline L. Moseley, Troy T. Banks, Claudia S. Maier, Jan F. Stevens, Joseph F. Quinn and Amala Soumyanath
    Drug Metabolism and Disposition October 2020, 48 (10) 1053-1063; DOI: https://doi.org/10.1124/dmd.120.090860
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    Application of Cryopreserved Human Intestinal Mucosa and Cryopreserved Human Enterocytes in the Evaluation of Herb-Drug Interactions: Evaluation of CYP3A Inhibitory Potential of Grapefruit Juice and Commercial Formulations of Twenty-Nine Herbal Supplements
    Carol Loretz, Ming-Chih David Ho, Novera Alam, Walter Mitchell and Albert P. Li
    Drug Metabolism and Disposition October 2020, 48 (10) 1084-1091; DOI: https://doi.org/10.1124/dmd.120.000033
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    Natural Products: Experimental Approaches to Elucidate Disposition Mechanisms and Predict Pharmacokinetic Drug Interactions
    Mary F. Paine
    Drug Metabolism and Disposition October 2020, 48 (10) 956-962; DOI: https://doi.org/10.1124/dmd.120.000182
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    Natural Products as Modulators of CES1 Activity
    Yuli Qian and John S. Markowitz
    Drug Metabolism and Disposition October 2020, 48 (10) 993-1007; DOI: https://doi.org/10.1124/dmd.120.000065

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