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Aldehyde Oxidase Contributes to All-Trans-Retinoic Acid Biosynthesis in Human Liver
Guo Zhong, Chris J. Seaman, Erickson M. Paragas, Huaqing Xi, Karla-Luise Herpoldt, Neil P. King, Jeffrey P. Jones and Nina Isoherranen

Drug Metabolism and Disposition March 2021, 49 (3) 202-211; DOI: https://doi.org/10.1124/dmd.120.000296
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In Vitro Metabolism of Slowly Cleared G Protein–Coupled Receptor 139 Agonist TAK-041 Using Rat, Dog, Monkey, and Human Hepatocyte Models (HepatoPac): Correlation with In Vivo Metabolism
Amin Kamel, Steve Bowlin, Natalie Hosea, Dimitrios Arkilo and Antonio Laurenza

Drug Metabolism and Disposition February 2021, 49 (2) 121-132; DOI: https://doi.org/10.1124/dmd.120.000246
Open Access
Predicting Volume of Distribution in Humans: Performance of In Silico Methods for a Large Set of Structurally Diverse Clinical Compounds
Neha Murad, Kishore K. Pasikanti, Benjamin D. Madej, Amanda Minnich, Juliet M. McComas, Sabrinia Crouch, Joseph W. Polli and Andrew D. Weber

Drug Metabolism and Disposition February 2021, 49 (2) 169-178; DOI: https://doi.org/10.1124/dmd.120.000202
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Prediction of Transporter-Mediated Rosuvastatin Hepatic Uptake Clearance and Drug Interaction in Humans Using Proteomics-Informed REF Approach
Vineet Kumar, Mengyue Yin, Kazuya Ishida, Laurent Salphati, Cornelis E.C.A. Hop, Christopher Rowbottom, Guangqing Xiao, Yurong Lai, Anita Mathias, Xiaoyan Chu, W. Griffith Humphreys, Mingxiang Liao, Zsuzsanna Nerada, Nóra Szilvásy, Scott Heyward and Jashvant D. Unadkat

Drug Metabolism and Disposition February 2021, 49 (2) 159-168; DOI: https://doi.org/10.1124/dmd.120.000204
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Use of Intravenous Infusion Study Design to Simultaneously Determine Brain Penetration and Systemic Pharmacokinetic Parameters in Rats
Keumhan Noh, Alicia Pietrasiewicz, Xingrong Liu and Cong Wei

Drug Metabolism and Disposition February 2021, 49 (2) 142-151; DOI: https://doi.org/10.1124/dmd.120.000242
Open Access
Impact of Direction of Transport on the Evaluation of Inhibition Potencies of Multidrug and Toxin Extrusion Protein 1 Inhibitors
Asami Saito, Naoki Ishiguro, Masahito Takatani, Bojan Bister and Hiroyuki Kusuhara

Drug Metabolism and Disposition February 2021, 49 (2) 152-158; DOI: https://doi.org/10.1124/dmd.120.000136
Open Access
Significance of Multiple Bioactivation Pathways for Meclofenamate as Revealed through Modeling and Reaction Kinetics
Mary Alexandra Schleiff, Noah R. Flynn, Sasin Payakachat, Benjamin Mark Schleiff, Anna O. Pinson, Dennis W. Province, S. Joshua Swamidass, Gunnar Boysen and Grover P. Miller

Drug Metabolism and Disposition February 2021, 49 (2) 133-141; DOI: https://doi.org/10.1124/dmd.120.000254
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Sex-, Age-, and Race/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers
Jie Liu, Julia Yue Cui, Yuan-Fu Lu, J. Christopher Corton and Curtis D. Klaassen

Drug Metabolism and Disposition January 2021, 49 (1) 111-119; DOI: https://doi.org/10.1124/dmd.120.000181
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Correction to “Investigating the Role of Altered Systemic Albumin Concentration on the Disposition of Theophylline in Adult and Pediatric Patients with Asthma by Using the Physiologically Based Pharmacokinetic Approach”
Drug Metabolism and Disposition January 2021, 49 (1) 120; DOI: https://doi.org/10.1124/dmd.120.090969err
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Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment
Simon G. Wong, Diane Ramsden, Shannon Dallas, Conrad Fung, Heidi J. Einolf, Jairam Palamanda, Liangfu Chen, Theunis C. Goosen, Y. Amy Siu, George Zhang, Donald Tweedie, Niresh Hariparsad, Barry Jones and Phillip D. Yates

Drug Metabolism and Disposition January 2021, 49 (1) 94-110; DOI: https://doi.org/10.1124/dmd.120.000055

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