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Characterization of Seasonal Pharmacokinetic Variability in Woodchucks
Jim Zheng, Scott Balsitis, Rex Santos, Bill J. Smith and Raju Subramanian

Drug Metabolism and Disposition November 2020, 48 (11) 1199-1209; DOI: https://doi.org/10.1124/dmd.120.000140
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Successful Prediction of Positron Emission Tomography–Imaged Metformin Hepatic Uptake Clearance in Humans Using the Quantitative Proteomics–Informed Relative Expression Factor Approach
Madhav Sachar, Vineet Kumar, Lars C. Gormsen, Ole Lajord Munk and Jashvant D. Unadkat

Drug Metabolism and Disposition November 2020, 48 (11) 1210-1216; DOI: https://doi.org/10.1124/dmd.120.000156
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Effects of Multiple Doses of Dichloroacetate on GSTZ1 Expression and Activity in Liver and Extrahepatic Tissues of Young and Adult Rats
Edwin J. Squirewell, Marci G. Smeltz, Laura Rowland-Faux, Lloyd P. Horne, Peter W. Stacpoole and Margaret O. James

Drug Metabolism and Disposition November 2020, 48 (11) 1217-1223; DOI: https://doi.org/10.1124/dmd.120.000142
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Announcement
Dr. Emily E. Scott

Drug Metabolism and Disposition November 2020, 48 (11) 1191; DOI: https://doi.org/10.1124/dmd.120.000249
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Exposure of Rats to Multiple Oral Doses of Dichloroacetate Results in Upregulation of Hepatic Glutathione Transferases and NAD(P)H Dehydrogenase [Quinone] 1
Edwin J. Squirewell, Ricky Mareus, Lloyd P. Horne, Peter W. Stacpoole and Margaret O. James

Drug Metabolism and Disposition November 2020, 48 (11) 1224-1230; DOI: https://doi.org/10.1124/dmd.120.000143
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Evaluation of the Disconnect between Hepatocyte and Microsome Intrinsic Clearance and In Vitro In Vivo Extrapolation Performance
Beth Williamson, Stephanie Harlfinger and Dermot F. McGinnity

Drug Metabolism and Disposition November 2020, 48 (11) 1137-1146; DOI: https://doi.org/10.1124/dmd.120.000131
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A Two-Tiered In Vitro Approach to De-Risk Drug Candidates for Potential Bile Salt Export Pump Inhibition Liabilities in Drug Discovery
Michael J. Hafey, Robert Houle, Keith Q. Tanis, Ian Knemeyer, Jackie Shang, Qing Chen, Andreas Baudy, James Monroe, Frank D. Sistare and Raymond Evers

Drug Metabolism and Disposition November 2020, 48 (11) 1147-1160; DOI: https://doi.org/10.1124/dmd.120.000086
Open Access
Characterization of Tissue Distribution, Catabolism, and Elimination of an Anti–Staphylococcus aureus THIOMAB Antibody-Antibiotic Conjugate in Rats
Hao Cai, Victor Yip, M. Violet Lee, Sylvia Wong, Ola Saad, Shuguang Ma, Nina Ljumanovic, S. Cyrus Khojasteh, Amrita V. Kamath and Ben-Quan Shen

Drug Metabolism and Disposition November 2020, 48 (11) 1161-1168; DOI: https://doi.org/10.1124/dmd.120.000092
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Impact of P-Glycoprotein–Mediated Active Efflux on Drug Distribution into Lumbar Cerebrospinal Fluid in Nonhuman Primates
Yoko Nagaya, Kazuhide Katayama, Hiroyuki Kusuhara and Yoshitane Nozaki

Drug Metabolism and Disposition November 2020, 48 (11) 1183-1190; DOI: https://doi.org/10.1124/dmd.120.000099
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Evaluation of In Vitro Models for Assessment of Human Intestinal Metabolism in Drug Discovery
Mari Davies, Prabha Peramuhendige, Lloyd King, Melanie Golding, Apoorva Kotian, Mark Penney, Syeda Shah and Nenad Manevski

Drug Metabolism and Disposition November 2020, 48 (11) 1169-1182; DOI: https://doi.org/10.1124/dmd.120.000111

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