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Adenosine-to-Inosine RNA Editing and N⁶-Methyladenosine Modification Modulating Expression of Drug Metabolizing Enzymes
Masataka Nakano and Miki Nakajima

Drug Metabolism and Disposition May 2022, 50 (5) 624-633; DOI: https://doi.org/10.1124/dmd.121.000390
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Direct and Sequential Bioactivation of Pemigatinib to Reactive Iminium Ion Intermediates Culminates in Mechanism-Based Inactivation of Cytochrome P450 3A
Lloyd Wei Tat Tang, Wan Wei, Ravi Kumar Verma, Siew Kwan Koh, Lei Zhou, Hao Fan and Eric Chun Yong Chan

Drug Metabolism and Disposition May 2022, 50 (5) 529-540; DOI: https://doi.org/10.1124/dmd.121.000804
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Estimation of Fraction Metabolized by Cytochrome P450 Enzymes Using Long-Term Cocultured Human Hepatocytes
Florian Klammers, Andreas Goetschi, Aynur Ekiciler, Isabelle Walter, Neil Parrott, Stephen Fowler and Kenichi Umehara

Drug Metabolism and Disposition May 2022, 50 (5) 566-575; DOI: https://doi.org/10.1124/dmd.121.000765
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Predicting Regional Respiratory Tissue and Systemic Concentrations of Orally Inhaled Drugs through a Novel PBPK Model
Mayur K. Ladumor and Jashvant D. Unadkat

Drug Metabolism and Disposition May 2022, 50 (5) 519-528; DOI: https://doi.org/10.1124/dmd.121.000789
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Experimental and Modeling Evidence Supporting the Trans-Inhibition Mechanism for Preincubation Time-Dependent, Long-Lasting Inhibition of Organic Anion Transporting Polypeptide 1B1 by Cyclosporine A
Saki Izumi, Yoshitane Nozaki, Wooin Lee and Yuichi Sugiyama

Drug Metabolism and Disposition May 2022, 50 (5) 541-551; DOI: https://doi.org/10.1124/dmd.121.000783
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Disposition of Nirmatrelvir, an Orally Bioavailable Inhibitor of SARS-CoV-2 3C-Like Protease, across Animals and Humans
Heather Eng, Alyssa L. Dantonio, Eugene P. Kadar, R. Scott Obach, Li Di, Jian Lin, Nandini C. Patel, Britton Boras, Gregory S. Walker, Jonathan J. Novak, Emi Kimoto, Ravi Shankar P. Singh and Amit S. Kalgutkar

Drug Metabolism and Disposition May 2022, 50 (5) 576-590; DOI: https://doi.org/10.1124/dmd.121.000801
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Correction to “Does Addition of Protein to Hepatocyte or Microsomal In Vitro Incubations Provide a Useful Improvement in In Vitro-In Vivo Extrapolation Predictability?”
Drug Metabolism and Disposition April 2022, 50 (4) 518; DOI: https://doi.org/10.1124/dmd.121.000677err
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Environmental Chemical Contribution to the Modulation of Bile Acid Homeostasis and Farnesoid X Receptor Signaling
Rulaiha E. Taylor, Anisha Bhattacharya and Grace L. Guo

Drug Metabolism and Disposition April 2022, 50 (4) 456-467; DOI: https://doi.org/10.1124/dmd.121.000388
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Pregnane X Receptor and the Gut-Liver Axis: A Recent Update
Moumita Dutta, Joe Jongpyo Lim and Julia Yue Cui

Drug Metabolism and Disposition April 2022, 50 (4) 478-491; DOI: https://doi.org/10.1124/dmd.121.000415
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The Complicated Role of Nuclear Factor Erythroid-Derived 2-Like 2 in Allergy and Asthma
Cheryl E. Rockwell, Yining Jin, Allison P. Boss, Luca M. Kaiser and Saamera Awali

Drug Metabolism and Disposition April 2022, 50 (4) 500-507; DOI: https://doi.org/10.1124/dmd.121.000414

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