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Metabolic Disposition of Triazolam and Clobazam in Humanized CYP3A Mice with a Double-Knockout Background of Mouse Cyp2c and Cyp3a Genes
Kaoru Kobayashi, Genki Minegishi, Nina Kuriyama, Atsushi Miyajima, Satoshi Abe, Kanako Kazuki and Yasuhiro Kazuki

Drug Metabolism and Disposition February 2023, 51 (2) 174-182; DOI: https://doi.org/10.1124/dmd.122.001087
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Functional Characterization of 12 Dihydropyrimidinase Allelic Variants in Japanese Individuals for the Prediction of 5-Fluorouracil Treatment-Related Toxicity
Eiji Hishinuma, Yoko Narita, Evelyn Marie Gutiérrez Rico, Akiko Ueda, Kai Obuchi, Yoshikazu Tanaka, Sakae Saito, Shu Tadaka, Kengo Kinoshita, Masamitsu Maekawa, Nariyasu Mano, Tomoki Nakayoshi, Akifumi Oda, Noriyasu Hirasawa and Masahiro Hiratsuka

Drug Metabolism and Disposition February 2023, 51 (2) 165-173; DOI: https://doi.org/10.1124/dmd.122.001045
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Renal Transporter Alterations in Patients with Chronic Liver Diseases: Nonalcoholic Steatohepatitis, Alcohol-Associated, Viral Hepatitis, and Alcohol-Viral Combination
Kayla L. Frost, Joseph L. Jilek, Shripad Sinari, Robert R. Klein, Dean Billheimer, Stephen H. Wright and Nathan J. Cherrington

Drug Metabolism and Disposition February 2023, 51 (2) 155-164; DOI: https://doi.org/10.1124/dmd.122.001038
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Bioavailability and Pharmacokinetics of Endoxifen in Female Rats and Dogs: Evidence to Support the Use of Endoxifen to Overcome the Limitations of CYP2D6-Mediated Tamoxifen Metabolism
Emily J. Koubek, Sarah A. Buhrow, Stephanie L. Safgren, Lee Jia, Matthew P. Goetz, Matthew M. Ames and Joel M. Reid

Drug Metabolism and Disposition February 2023, 51 (2) 183-192; DOI: https://doi.org/10.1124/dmd.122.000929
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Impact of direction of transport on the evaluation of substrate recognition of mouse multidrug and toxin extrusion protein 1 (mMate1)
Asami Saito, Tomoko Kito, Naoki Ishiguro, Masahito Takatani, Takashi Kudo, Bojan Bister and Hiroyuki Kusuhara

Drug Metabolism and Disposition January 20, 2023, DMD-AR-2022-001115; DOI: https://doi.org/10.1124/dmd.122.001115
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Newly Identified Tree Shrew Cytochrome P450 2A13 (CYP2A13) is Expressed in Liver and Lung and Encodes a Functional Drug-Metabolizing Enzyme Similar to Dog CYP2A13 and Pig CYP2A19
Genki Ushirozako, Yutaro Noda, Norie Murayama, Hiroaki Kawaguchi, Kyoko Tsukiyama-Kohara, Hiroshi Yamazaki and Yasuhiro Uno

Drug Metabolism and Disposition January 20, 2023, DMD-AR-2022-001152; DOI: https://doi.org/10.1124/dmd.122.001152
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Fifty years of aryl hydrocarbon receptor research as reflected in the pages of Drug Metabolism and Disposition
David S. Riddick

Drug Metabolism and Disposition January 18, 2023, DMD-MR-2022-001009; DOI: https://doi.org/10.1124/dmd.122.001009
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Unusual Biotransformation Reactions of Drugs and Drug Candidates
Emre M. Isin

Drug Metabolism and Disposition January 18, 2023, DMD-MR-2021-000744; DOI: https://doi.org/10.1124/dmd.121.000744
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Biotransformation of the Novel Myeloperoxidase Inhibitor AZD4831 in Preclinical Species and Humans
Ulrik Jurva, Lars Weidolf, Ann-Sofie Sandinge, Carina Leandersson, Anja Ekdahl, Xue-Qing Li, Thomas Antonsson, Johan Sundell, Kristina Westerlund, Carl Amilon, Tord Inghardt and V. Sashi Gopaul

Drug Metabolism and Disposition January 18, 2023, DMD-AR-2022-001099; DOI: https://doi.org/10.1124/dmd.122.001099
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Application of Accelerator Mass Spectrometry to Characterize the Mass Balance Recovery and Disposition of AZD4831, a Novel Myeloperoxidase Inhibitor, Following Administration of an Oral Radiolabeled Microtracer Dose in Humans
Chandrali Bhattacharya, Ann-Sofie Sandinge, Ryan A. Bragg, Maria Heijer, Jingjing Yan, Linda C. Andersson, Ulrik Jurva, Marta Pelay-Gimeno, Wouter H.J. Vaes, Rianne A.F. de Ligt, Malin Gränfors, Carl Amilon, Eva-Lotte Lindstedt, Somasekhara R. Menakuru, Pavlo Garkaviy, Lars Weidolf and V. Sashi Gopaul

Drug Metabolism and Disposition January 13, 2023, DMD-AR-2022-001100; DOI: https://doi.org/10.1124/dmd.122.001100

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