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Potential and Challenges in Application of Physiologically Based Pharmacokinetic Modeling in Predicting Diarrheal Disease Impact on Oral Drug Pharmacokinetics
Cindy X. Zhang and Samuel L.M. Arnold

Drug Metabolism and Disposition September 15, 2023, DMD-MR-2022-000964; DOI: https://doi.org/10.1124/dmd.122.000964
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The Metabolism of Lufotrelvir, a Prodrug Investigated for the Treatment of SARS-COV2 in Humans Following Intravenous Administration
Narayan Cheruvu, Esther van Duijn, Pieter A. Spigt, Ioana M. Barbu, Sima S. Toussi, Klaas Schildknegt, Rhys M. Jones and R. Scott Obach

Drug Metabolism and Disposition October 2023, 51 (10) 1419-1427; DOI: https://doi.org/10.1124/dmd.123.001416
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Analysis of the Bile Acid Composition in a Fibroblast Growth Factor 19-Expressing Liver-Humanized Mouse Model and Its Use for CYP3A4-Mediated Drug–Drug Interaction Studies
Mario Mezler, Robert S. Jones, Dewakar Sangaraju, Devorah C. Goldman, Matthew Hoffmann, Aki T. Heikkinen, Janne Mannila, Jae H. Chang, Lander Foquet, Sandeepraj Pusalkar, Paresh P. Chothe and Nico Scheer

Drug Metabolism and Disposition October 2023, 51 (10) 1391-1402; DOI: https://doi.org/10.1124/dmd.123.001398
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Recent Advances in Mass Spectrometry-Based Spatially Resolved Molecular Imaging of Drug Disposition and Metabolomics
Yu Chen, Ying Liu, Ximei Li, Yan He, Weiwei Li, Ying Peng and Jiang Zheng

Drug Metabolism and Disposition October 2023, 51 (10) 1273-1283; DOI: https://doi.org/10.1124/dmd.122.001069
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In Vivo Metabolite Profiles of an N-Acetylgalactosamine–Conjugated Antisense Oligonucleotide AZD8233 Using Liquid Chromatography High-Resolution Mass Spectrometry: A Cross-Species Comparison in Animals and Humans
Xue-Qing Li, Marie Elebring, Anders Dahlén and Lars Weidolf

Drug Metabolism and Disposition October 2023, 51 (10) 1350-1361; DOI: https://doi.org/10.1124/dmd.123.001370
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The Absolute Bioavailability and Absorption, Metabolism, and Excretion of Ipatasertib, a Potent and Highly Selective Protein Kinase B (Akt) Inhibitor
Ryan H. Takahashi, Vikram Malhi, Bianca M. Liederer, Sungjoon Cho, Yuzhong Deng, Brian Dean, James Nugteren, Edward Yost, Mohammad A. Al-Sayah, Rucha Sane, Smita Kshirsagar, Shuguang Ma and Luna Musib

Drug Metabolism and Disposition October 2023, 51 (10) 1332-1341; DOI: https://doi.org/10.1124/dmd.122.001175
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Fluorescence-Based High-Throughput Assays for Investigating Cytochrome P450 Enzyme-Mediated Drug–Drug Interactions
Rongjing He, Ziru Dai, Moshe Finel, Feng Zhang, Dongzhu Tu, Ling Yang and Guangbo Ge

Drug Metabolism and Disposition October 2023, 51 (10) 1254-1272; DOI: https://doi.org/10.1124/dmd.122.001068
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NEAT1_2 and DAZAP1, Paraspeckle Components, Interact with PXR to Negatively Regulate CYP3A4 Induction
Rei Mitamura, Masataka Nakano, Motoki Isono, Kiamu Kurosawa, Tatsuki Fukami and Miki Nakajima

Drug Metabolism and Disposition October 2023, 51 (10) 1230-1237; DOI: https://doi.org/10.1124/dmd.122.001065
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Utility of Minimal Physiologically Based Pharmacokinetic Models for Assessing Fractional Distribution, Oral Absorption, and Series-Compartment Models of Hepatic Clearance
Xiaonan Li and William J. Jusko

Drug Metabolism and Disposition October 2023, 51 (10) 1403-1418; DOI: https://doi.org/10.1124/dmd.123.001403
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Special Section on New and Emerging Areas and Technologies in Drug Metabolism and Disposition, Part I–Editorial
Xiao-bo Zhong, Yurong Lai and Xinxin Ding

Drug Metabolism and Disposition October 2023, 51 (10) 1227-1229; DOI: https://doi.org/10.1124/dmd.123.001480

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