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Icotinib Induces Mechanism-Based Inactivation of Recombinant Human CYP3A4/5 Possibly via Heme Destruction by Ketene Intermediate
Chen Sun, Huimin Zhao, Wei Li, Yudi Jia, Yi Yang, Ying Peng and Jiang Zheng

Drug Metabolism and Disposition October 2021, 49 (10) 892-901; DOI: https://doi.org/10.1124/dmd.121.000369
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Tetrahydrocannabinol and Its Major Metabolites Are Not (or Are Poor) Substrates or Inhibitors of Human P-Glycoprotein [ATP-Binding Cassette (ABC) B1] and Breast Cancer Resistance Protein (ABCG2)
Xin Chen, Jashvant D. Unadkat and Qingcheng Mao

Drug Metabolism and Disposition October 2021, 49 (10) 910-918; DOI: https://doi.org/10.1124/dmd.121.000505
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Cytochrome b₅ Binds Tightly to Several Human Cytochrome P450 Enzymes
Donghak Kim, Vitchan Kim, Yasuhiro Tateishi and F. Peter Guengerich

Drug Metabolism and Disposition October 2021, 49 (10) 902-909; DOI: https://doi.org/10.1124/dmd.121.000475
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Cytochrome P450 Binding and Bioactivation of Tumor-targeted Duocarmycin Agents
Aaron G. Bart, Goreti Morais, Venu R. Vangala, Paul M. Loadman, Klaus Pors and Emily E. Scott

Drug Metabolism and Disposition October 4, 2021, DMD-AR-2021-000642; DOI: https://doi.org/10.1124/dmd.121.000642
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Endogenous plasma kynurenic acid in human: a newly discovered biomarker for drug-drug interactions involving in OAT1 and OAT3 inhibition
Jennifer Tang, Hong Shen, Xiaofeng Zhao, Vinay K. Holenarsipur, T. Thanga Mariappan, Yueping Zhang, Erika Panfen, Jim Zheng, W. Griffith Humphreys and Yurong Lai

Drug Metabolism and Disposition October 1, 2021, DMD-AR-2021-000486; DOI: https://doi.org/10.1124/dmd.121.000486
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Characterization of cytosolic glutathione-S- transferases (GSTs) involved in the metabolism of the aromatase inhibitor, Exemestane
Irina Teslenko, Christy J.W. Watson, Zuping Xia, Gang Chen and Philip Lazarus

Drug Metabolism and Disposition September 30, 2021, DMD-AR-2021-000635; DOI: https://doi.org/10.1124/dmd.121.000635
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Correction to “In Vivo-to-in Vitro Extrapolation of Transporter-Mediated Renal Clearance: Relative Expression Factor Versus Relative Activity Factor Approach”
Drug Metabolism and Disposition September 2021, 49 (9) 869; DOI: https://doi.org/10.1124/dmd.121.000367err
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Infigratinib Is a Reversible Inhibitor and Mechanism-Based Inactivator of Cytochrome P450 3A4
Lloyd Wei Tat Tang, Jian Wei Teng, Ravi Kumar Verma, Siew Kwan Koh, Lei Zhou, Mei Lin Go, Hao Fan and Eric Chun Yong Chan

Drug Metabolism and Disposition September 2021, 49 (9) 856-868; DOI: https://doi.org/10.1124/dmd.121.000508
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HLM-beads: Rapid assessment of non-specific binding to human liver microsomes using magnetizable beads
Ting Wang, Andrea Whitcher-Johnstone, Monica Keith-Luzzi and Tom S. Chan

Drug Metabolism and Disposition September 24, 2021, DMD-AR-2021-000575; DOI: https://doi.org/10.1124/dmd.121.000575
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Leveraging Physiologically Based Pharmacokinetic Modeling and Experimental Data to Guide Dosing Modification of CYP3A-Mediated Drug-Drug Interactions in the Pediatric Population
Sara N. Salerno, Fernando O. Carreño, Andrea N. Edginton, Michael Cohen-Wolkowiez and Daniel Gonzalez

Drug Metabolism and Disposition September 2021, 49 (9) 844-855; DOI: https://doi.org/10.1124/dmd.120.000318

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