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Target-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fc-fusion Proteins at Pharmacologically Active Doses
Zheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois D. Lehman-McKeeman, Paul Morin and Robert F Graziano

Drug Metabolism and Disposition May 11, 2022, DMD-AR-2021-000799; DOI: https://doi.org/10.1124/dmd.121.000799
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Sinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance Model
Philip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W Yucha, Swapan K. Chowdhury and Paresh P. Chothe

Drug Metabolism and Disposition May 11, 2022, DMD-AR-2022-000836; DOI: https://doi.org/10.1124/dmd.122.000836
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Isotretinoin and its metabolites alter mRNA of multiple enzyme and transporter genes in vitro but downregulation of OATP1B1 does not translate to the clinic
Aprajita S. Yadav, Faith Stevison, Mika Kosaka, Susan Wong, Jane R. Kenny, John K. Amory and Nina Isoherranen

Drug Metabolism and Disposition May 11, 2022, DMD-AR-2022-000882; DOI: https://doi.org/10.1124/dmd.122.000882
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Stereoselective metabolism of bupropion to active metabolites in cellular fractions of human liver and intestine.
Nadia O. Bamfo, Jessica Bo Li Lu and Zeruesenay Desta

Drug Metabolism and Disposition May 5, 2022, DMD-AR-2022-000867; DOI: https://doi.org/10.1124/dmd.122.000867
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Impact of inflammation and infection on the expression of amino acid transporters in the placenta: A minireview
Eliza R McColl, Milena Hurtarte and Micheline Piquette-Miller

Drug Metabolism and Disposition May 5, 2022, DMD-MR-2021-000703; DOI: https://doi.org/10.1124/dmd.121.000703
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Prediction of Carboxylesterase 1 (CES1)-mediated In Vivo Drug Interaction between Methylphenidate and Cannabinoids using Static and Physiologically Based Pharmacokinetic Models
Yuli Qian and John S. Markowitz

Drug Metabolism and Disposition May 5, 2022, DMD-AR-2021-000823; DOI: https://doi.org/10.1124/dmd.121.000823
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Metabolic Activation of the Acrylamide Michael Acceptor Warhead in Futibatinib to an Epoxide Intermediate Engenders Covalent Inactivation of Cytochrome P450 3A
Lloyd Wei Tat Tang, Jiaxin Fu, Siew Kwan Koh, Guoyi Wu, Lei Zhou and Eric Chun Yong Chan

Drug Metabolism and Disposition May 5, 2022, DMD-AR-2022-000895; DOI: https://doi.org/10.1124/dmd.122.000895
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Understanding Inter-individual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-limited Multi-compartment Liver Model in a Population Based PBPK Framework
Mian Zhang, Ciarán Fisher, Iain Gardner, Xian Pan, Peter Kilford, Frederic Bois and Masoud Jamei

Drug Metabolism and Disposition May 3, 2022, DMD-AR-2021-000818; DOI: https://doi.org/10.1124/dmd.121.000818
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Regulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-β/Activin Receptor-Like Kinase 1 (TGF-β/ALK1) Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors (i.e., Statins)
Robert D. Betterton, Wazir Abdullahi, Erica I. Williams, Jeffrey L. Lochhead, Hrvoje Brzica, Joshua A Stanton, Elizabeth Reddell, Chidinma Ogbonnaya, Thomas P Davis and Patrick T. Ronaldson

Drug Metabolism and Disposition May 3, 2022, DMD-AR-2021-000781; DOI: https://doi.org/10.1124/dmd.121.000781
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Metabolism and Disposition of [¹⁴C]Pevonedistat, a First-In-Class NEDD8‑Activating Enzyme Inhibitor, After Intravenous Infusion to Patients With Advanced Solid Tumors
Jayaprakasam Bolleddula, Hao Chen, Lawrence Cohen, Xiaofei Zhou, Sandeepraj Pusalkar, Allison Berger, Farhad Sedarati, Karthik Venkatakrishnan and Swapan K. Chowdhury

Drug Metabolism and Disposition May 3, 2022, DMD-AR-2022-000842; DOI: https://doi.org/10.1124/dmd.122.000842

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