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Drug Metabolism & Disposition

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Latest Articles

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    Target-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fc-fusion Proteins at Pharmacologically Active Doses
    Zheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, Zheng Lin, Jaren Arbanas, Stanley Krystek, James Loy, Yuan Cheng, Stephen Carl, Samantha Pace, Yun Wang, John Mehl, Shihua Xu, Krishna Vasudevan, Miranda Broz, Lois D. Lehman-McKeeman, Paul Morin and Robert F Graziano
    Drug Metabolism and Disposition May 11, 2022, DMD-AR-2021-000799; DOI: https://doi.org/10.1124/dmd.121.000799
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    Sinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance Model
    Philip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W Yucha, Swapan K. Chowdhury and Paresh P. Chothe
    Drug Metabolism and Disposition May 11, 2022, DMD-AR-2022-000836; DOI: https://doi.org/10.1124/dmd.122.000836
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    Isotretinoin and its metabolites alter mRNA of multiple enzyme and transporter genes in vitro but downregulation of OATP1B1 does not translate to the clinic
    Aprajita S. Yadav, Faith Stevison, Mika Kosaka, Susan Wong, Jane R. Kenny, John K. Amory and Nina Isoherranen
    Drug Metabolism and Disposition May 11, 2022, DMD-AR-2022-000882; DOI: https://doi.org/10.1124/dmd.122.000882
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    Stereoselective metabolism of bupropion to active metabolites in cellular fractions of human liver and intestine.
    Nadia O. Bamfo, Jessica Bo Li Lu and Zeruesenay Desta
    Drug Metabolism and Disposition May 5, 2022, DMD-AR-2022-000867; DOI: https://doi.org/10.1124/dmd.122.000867
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    Impact of inflammation and infection on the expression of amino acid transporters in the placenta: A minireview
    Eliza R McColl, Milena Hurtarte and Micheline Piquette-Miller
    Drug Metabolism and Disposition May 5, 2022, DMD-MR-2021-000703; DOI: https://doi.org/10.1124/dmd.121.000703
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    Prediction of Carboxylesterase 1 (CES1)-mediated In Vivo Drug Interaction between Methylphenidate and Cannabinoids using Static and Physiologically Based Pharmacokinetic Models
    Yuli Qian and John S. Markowitz
    Drug Metabolism and Disposition May 5, 2022, DMD-AR-2021-000823; DOI: https://doi.org/10.1124/dmd.121.000823
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    Metabolic Activation of the Acrylamide Michael Acceptor Warhead in Futibatinib to an Epoxide Intermediate Engenders Covalent Inactivation of Cytochrome P450 3A
    Lloyd Wei Tat Tang, Jiaxin Fu, Siew Kwan Koh, Guoyi Wu, Lei Zhou and Eric Chun Yong Chan
    Drug Metabolism and Disposition May 5, 2022, DMD-AR-2022-000895; DOI: https://doi.org/10.1124/dmd.122.000895
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    Understanding Inter-individual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-limited Multi-compartment Liver Model in a Population Based PBPK Framework
    Mian Zhang, Ciarán Fisher, Iain Gardner, Xian Pan, Peter Kilford, Frederic Bois and Masoud Jamei
    Drug Metabolism and Disposition May 3, 2022, DMD-AR-2021-000818; DOI: https://doi.org/10.1124/dmd.121.000818
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    Regulation of Blood-Brain Barrier Transporters by Transforming Growth Factor-β/Activin Receptor-Like Kinase 1 (TGF-β/ALK1) Signaling: Relevance to the Brain Disposition of 3-Hydroxy-3-Methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitors (i.e., Statins)
    Robert D. Betterton, Wazir Abdullahi, Erica I. Williams, Jeffrey L. Lochhead, Hrvoje Brzica, Joshua A Stanton, Elizabeth Reddell, Chidinma Ogbonnaya, Thomas P Davis and Patrick T. Ronaldson
    Drug Metabolism and Disposition May 3, 2022, DMD-AR-2021-000781; DOI: https://doi.org/10.1124/dmd.121.000781
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    Metabolism and Disposition of [14C]Pevonedistat, a First-In-Class NEDD8‑Activating Enzyme Inhibitor, After Intravenous Infusion to Patients With Advanced Solid Tumors
    Jayaprakasam Bolleddula, Hao Chen, Lawrence Cohen, Xiaofei Zhou, Sandeepraj Pusalkar, Allison Berger, Farhad Sedarati, Karthik Venkatakrishnan and Swapan K. Chowdhury
    Drug Metabolism and Disposition May 3, 2022, DMD-AR-2022-000842; DOI: https://doi.org/10.1124/dmd.122.000842

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