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Feature, Function, and Information of Drug Transporter–Related Databases
Jiayi Yin, Fengcheng Li, Zhaorong Li, Lushan Yu, Feng Zhu and Su Zeng

Drug Metabolism and Disposition January 2022, 50 (1) 76-85; DOI: https://doi.org/10.1124/dmd.121.000419
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Overview of Current Herb–Drug Interaction Databases
Yufeng Zhang, Chung Man Ip, Yuen Sze Lai and Zhong Zuo

Drug Metabolism and Disposition January 2022, 50 (1) 86-94; DOI: https://doi.org/10.1124/dmd.121.000420
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Cytochrome P450 Binding and Bioactivation of Tumor-Targeted Duocarmycin Agents
Aaron G. Bart, Goreti Morais, Venu R. Vangala, Paul M. Loadman, Klaus Pors and Emily E. Scott

Drug Metabolism and Disposition January 2022, 50 (1) 49-57; DOI: https://doi.org/10.1124/dmd.121.000642
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Addressing Today’s Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam
Stephen Fowler, Andreas Brink, Yumi Cleary, Andreas Günther, Katja Heinig, Christophe Husser, Heidemarie Kletzl, Nicole Kratochwil, Lutz Mueller, Mark Savage, Cordula Stillhart, Dietrich Tuerck, Mohammed Ullah, Kenichi Umehara and Agnès Poirier

Drug Metabolism and Disposition January 2022, 50 (1) 65-75; DOI: https://doi.org/10.1124/dmd.121.000563
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New Pharmacokinetic Parameters of Imaging Substrates Quantified from Rat Liver Compartments
Catherine M. Pastor and Kim L.R. Brouwer

Drug Metabolism and Disposition January 2022, 50 (1) 58-64; DOI: https://doi.org/10.1124/dmd.121.000546
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Attenuated Ochratoxin A Transporter Expression in a Mouse Model of Nonalcoholic Steatohepatitis Protects against Proximal Convoluted Tubule Toxicity.
Joseph L. Jilek, Kayla L. FROST, Solène MARIE, Cassandra M. MYERS, Michael GOEDKEN, Stephen H. Wright and Nathan J. CHERRINGTON

Drug Metabolism and Disposition December 17, 2021, DMD-MR-2021-000451; DOI: https://doi.org/10.1124/dmd.121.000451
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Emerging Roles of the Human Solute Carrier 22 Family
Sook Wah Yee and Kathleen M. Giacomini

Drug Metabolism and Disposition December 17, 2021, DMD-MR-2021-000702; DOI: https://doi.org/10.1124/dmd.121.000702
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Pharmacokinetic Drug-Drug Interactions with Drugs Approved by the US Food and Drug Administration in 2020: Mechanistic Understanding and Clinical Recommendations
Jingjing Yu, Yan Wang and Isabelle Ragueneau-Majlessi

Drug Metabolism and Disposition January 2022, 50 (1) 1-7; DOI: https://doi.org/10.1124/dmd.121.000401
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Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver
J. Steven Leeder, Jean C. Dinh, Andrea Gaedigk, Vincent S. Staggs, Bhagwat Prasad and Robin E. Pearce

Drug Metabolism and Disposition January 2022, 50 (1) 24-32; DOI: https://doi.org/10.1124/dmd.121.000623
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Simultaneous Evaluation of Membrane Permeability and UDP-Glucuronosyltransferase–Mediated Metabolism of Food-Derived Compounds Using Human Induced Pluripotent Stem Cell–Derived Small Intestinal Epithelial Cells
Takashi Kitaguchi, Taisei Mizota, Mina Ito, Katsutoshi Ohno, Kazuhiro Kobayashi, Isamu Ogawa, Shimeng Qiu, Takahiro Iwao, Nobumitsu Hanioka, Mitsuru Tanaka and Tamihide Matsunaga

Drug Metabolism and Disposition January 2022, 50 (1) 17-23; DOI: https://doi.org/10.1124/dmd.121.000605

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